Aug 15, 2024
SAS Defines Hybrid Reality For Quantum Computing
Posted by Genevieve Klien in categories: computing, internet, quantum physics
Quantum is huge. Because quantum computing allows us to step beyond the current limitations of digital systems, it paves the way for a new era of computing machines with previously unthinkable power. Without recounting another simplified explanation of how quantum gets its power at length, we can reference the double-slit experiment and perhaps the spinning coin explanation.
A coin sat on a desk is either heads or tails, rather like the 1s and 0s that express the on or off values in binary code. Quantum theorists would prefer we think of the coin above the desk, spinning in the air. In this state, the coin is both heads and tails at the same time. This is because, at the quantum level, both values exist until we make an observation of its state at any given point in time. We could further increase the number of positions possible (literally known as quantum superposition) by altering the angle of view we take on the coin, which is somewhat similar to how we work with qubits in quantum mechanics.
So then, Schrödinger’s cat is both alive and dead at the same time and the dummies guide to quantum entanglement is out there on the web if needed. What matters most now is how we will make practical use of quantum computing and where it will be applied for best advantage.
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this immune strategy by instead leveraging DNA synthesis, but the identities and functions of their DNA products remain largely unknown. Here we show that DRT2 systems execute an unprecedented immunity mechanism that involves de novo gene synthesis via rolling-circle reverse transcription of a non-coding RNA (ncRNA). Unbiased profiling of RT-associated RNA and DNA ligands in DRT2-expressing cells revealed that reverse transcription generates concatenated cDNA repeats through programmed template jumping on the ncRNA. The presence of phage then triggers second-strand cDNA synthesis, leading to the production of long double-stranded DNA. Remarkably, this DNA product is efficiently transcribed, generating messenger RNAs that encode a stop codon-less, never-ending ORF (neo) whose translation causes potent growth arrest. Phylogenetic analyses and screening of diverse DRT2 homologs further revealed broad conservation of rolling-circle reverse transcription and Neo protein function. Our work highlights an elegant expansion of genome coding potential through RNA-templated gene creation, and challenges conventional paradigms of genetic information encoded along the one-dimensional axis of genomic DNA.
