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Collagen exists as liquid droplets inside living cells, study reveals

Collagen, the protein that builds skin, bones, tendons and organs, exists inside cells as a liquid-like droplet rather than the long, rigid rod seen in textbooks over the last half century, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

Space Habitats: The Megastructures We’ll Call Home

Explore the future of space habitats, from rotating cylinders and torus colonies to orbital cities, asteroid homes, and the megastructures humanity may one day live inside.

Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur.
Watch my exclusive video Nearby Supernovae: https://nebula.tv/videos/isaacarthur–… SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Space Habitats: The Megastructures We’ll Call Home Written, Produced & Narrated by: Isaac Arthur Editors: Briana Brownell, Ludwig Luska Select imagery/video supplied by Getty Images, Anthrofuturism, Apogii.uk, Bryan Versteeg, Fishy Tree, Katie Byrne, Jarred Eagley, Jeremy Jozwik, Justin Dixon, Ken York YD Visual, Neil Blevins, Sergio Botero, Steve Bowers, and Udo Schroeter Music by Epidemic Sound: http://nebula.tv/epidemic and Markus Junnikkala, Phase Shift, Kai Engel, Chris Zabriskie, Taras Harkavyi, and Stellardrone 0:00 Intro 4:37 The Sunflower 14:07 The O’Neill Cylinder 49:00 Lewis One 57:40 Stanford Torus 1:22:19 Kalpana One 1:28:14 Nebula 1:29:27 Bernal Sphere 1:54:13 Bishop Ring 2:03:23 Topopolis 2:27:36 McKendree Cylinder 2:33:57 Hammer Habs 2:59:01 Rungworlds 3:04:35 Conglomerations 3:38:45 Epilogue.

🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall
🌐 Visit our Website: http://www.isaacarthur.net.
❤️ Support us on Patreon: / isaacarthur.
⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a
👥 Facebook Group: / 1583992725237264
📣 Reddit Community: / isaacarthur.
🐦 Follow on Twitter / X: / isaac_a_arthur.
💬 SFIA Discord Server: / discord.
Credits:
Space Habitats: The Megastructures We’ll Call Home.
Written, Produced \& Narrated by: Isaac Arthur.
Editors: Briana Brownell, Ludwig Luska.
Select imagery/video supplied by Getty Images, Anthrofuturism, Apogii.uk, Bryan Versteeg, Fishy Tree, Katie Byrne, Jarred Eagley, Jeremy Jozwik, Justin Dixon, Ken York YD Visual, Neil Blevins, Sergio Botero, Steve Bowers, and Udo Schroeter.
Music by Epidemic Sound: http://nebula.tv/epidemic and Markus Junnikkala, Phase Shift, Kai Engel, Chris Zabriskie, Taras Harkavyi, and Stellardrone.

0:00 Intro.
4:37 The Sunflower.
14:07 The O’Neill Cylinder.
49:00 Lewis One.
57:40 Stanford Torus.
1:22:19 Kalpana One.
1:28:14 Nebula.
1:29:27 Bernal Sphere.
1:54:13 Bishop Ring.
2:03:23 Topopolis.
2:27:36 McKendree Cylinder.
2:33:57 Hammer Habs.
2:59:01 Rungworlds.
3:04:35 Conglomerations.
3:38:45 Epilogue

Scientists Put a Fruit Fly’s Brain in a Computer Simulation… What It Did Is Now Scaring Scientists

Scientists have achieved an incredible breakthrough by recreating the brain of a fruit fly inside a computer simulation. By mapping around 140,000 neurons and millions of connections, they built a digital brain that can sense its environment, process information, and even control a virtual body. In the simulation, the digital fly was able to search for food, respond to stimuli, and show behaviors that were not directly programmed by scientists. This discovery shows how powerful neural connections are in generating behavior. It also raises fascinating questions about the nature of intelligence, consciousness, and whether complex brains—including ours—could one day be simulated in computers.

sources

https://eon.systems/updates/embodied-brain-emulation.

Research Paper for more information.
https://marginalrevolution.com/margin

#Science.
#Neuroscience.
#ArtificialIntelligence.
#BrainSimulation.
#FruitFlyBrain.
#Connectome.
#FutureTech.
#ComputerSimulation.
#NeuralNetworks.
#ScienceDiscovery

Recursive Self Improvement

Computer, load up celery man.
Can AI build AI? Yes, and it already is. Sort of. I showcase the ability of AI agents like claude code to perform AI research, to build and optimize machine learning algorithms. I put various state-of-the-art LLMs like claude Mythos/Fable into an endless recursive research loop and have them build a neural network that learns the shape of the mandelbrot set. It is inspired by Andrej Karpathy’s autoresearch. While we watch this loop, I express my thoughts on the concept of recursive self improvement, arguing that it is possible, hard, and dangerous.
Sorry for the bitrate issues.

Fractalsearch repo: coming soon!

~SUPPORT ME~
Learn to code faster with Scrimba! (saves you 20% and support me): https://scrimba.com/?via=EmergentGarden.
Patreon: / emergentgarden.
Twitter: / max_romana.
Bluesky: https://bsky.app/profile/emergentgard… Autoreasearch: https://github.com/karpathy/autoresearch Mandelbrot Zoom: • Mandelbrot World Record Attempt — Part 1 (… Celery Man: • Tim and Eric — Celery Man Karpathy’s Youtube: / @andrejkarpathy Self-building Cranes: • How Tower Cranes Build Themselves Darwin-Godel Machine: https://arxiv.org/abs/2505.22954 Hashgrid Paper: https://arxiv.org/abs/2201.05989 Anthropic’s RSI Article: https://www.anthropic.com/institute/r… Fable System Card: https://www-cdn.anthropic.com/d00db56… My Music Guy: / @acolyte-compositions “Equatorial Complex” Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/b… ~TIMESTAMPS~ (0:00) Recursive Self Improvement (3:14) fractalsearch (9:56) RSI is Possible (15:03) RSI is Hard (21:52) RSI is Dangerous (26:03) Results (28:28) Cost (29:29) Takeoff.

~SOURCES~
Autoreasearch: https://github.com/karpathy/autoresearch.
Mandelbrot Zoom: • Mandelbrot World Record Attempt — Part 1 (…
Celery Man: • Tim and Eric — Celery Man.
Karpathy’s Youtube: / @andrejkarpathy.
Self-building Cranes: • How Tower Cranes Build Themselves.
Darwin-Godel Machine: https://arxiv.org/abs/2505.22954
Hashgrid Paper: https://arxiv.org/abs/2201.05989
Anthropic’s RSI Article: https://www.anthropic.com/institute/r
Fable System Card: https://www-cdn.anthropic.com/d00db56

My Music Guy: / @acolyte-compositions.

The World in 100 Years FULL EPISODE | Science Fiction Documentary

What will the world really look like in 100 years?

Forget flying cars, impossible megacities, and science-fiction fantasies. This documentary explores a realistic vision of life in the year 2,126 based on current trends in artificial intelligence, climate adaptation, biotechnology, energy, space exploration, economics, and human evolution.

How will cities change as the planet warms? What happens when AI becomes part of everyday life? Will humans live to 120 years? Will neural implants blur the line between biology and technology? Could Mars become a permanent home for thousands of people? And what happens to society when work, truth, privacy, and even human identity are redefined?

Travel one century into the future and discover a world that is both familiar and radically different from our own. A world shaped by the choices humanity is making right now.

From climate-engineered cities and fusion-powered civilizations to Martian settlements, artificial intelligence, genetic medicine, digital consciousness, and the search for life beyond Earth, this is a deep exploration of the most plausible future awaiting our species.

The future isn’t written.

Harnessing the stem cell potential in the human hippocampus to limit cognitive aging

The field of human adult neurogenesis has been controversial despite mounting evidence. This Perspective proposes moving beyond debating the existence of adult neurogenesis, and towards discovering strategies to harness endogenous stem cell potential for resilience against cognitive aging.

E= mc^2

Einstein’s famous equation has grown into one of the great symbols of the 20th century. It is the one equation in science that people recognize, if any is. It has a kind of iconic status and dual connotations: the brilliance and insight of Einstein and the darkness of atomic bombs. Images.

The basic idea behind the formula E=mc2 is easy to state. Mass and energy are really just the same thing. At first that seems impossible.

• Mass is a measure of the quantity of stuff and manifests as a resistance to acceleration. A body with little mass, like a pebble, is easy to set in motion.

Antibody-guided nanoparticles target blood cancer cells in bone marrow

New research co-led by Indiana University School of Medicine scientists presents a significant step toward more precise and effective cancer treatments by using a breakthrough method to deliver therapies directly to cancer cells. The study was recently published in ACS Nano.

“One of the biggest challenges in cancer treatment is that many drugs not only attack cancer cells but also harm healthy cells throughout the body,” said Ngoc Tung Tran, Ph.D., the study’s co-lead author and an assistant professor of pediatrics and of microbiology and immunology at the IU School of Medicine. “This can lead to serious side effects and limit how well the treatment works. Our goal is to develop a smarter way to deliver cancer therapy directly to cancer cells while avoiding normal tissues.”

In the study, researchers focused on multiple myeloma, a blood cancer that mainly grows in plasma cells found in the bone marrow. Using mouse models, they carried therapeutic molecules into cells by using a delivery system of tiny, fat-based particles called lipid nanoparticles, or LNPs.

Our brains may be automatically filtering out negative words

We tend to assume that emotionally charged words are more likely to grab our attention. An insult shouted across a crowded room or a disturbing phrase overheard on television can seem impossible to ignore. But a new study published in Psychological Science suggests the opposite may happen before words reach conscious awareness.

Researchers at the Hebrew University of Jerusalem found that when people were focused on a visual task, they were less likely to consciously notice negative spoken words than neutral ones. The findings offer new insight into how the brain determines which information enters conscious awareness and which remains outside it.

“This study is a nice example of how our conscious intuitions regarding what we notice are not always what our unconscious is doing,” said lead author Gal R. Chen, a doctoral candidate in psychology at the Hebrew University of Jerusalem.

UIC scientists source anti-cancer treatment in bacteria

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer tumors.

When tested in combination with radiation in animal models of prostate cancer, it was highly effective — the approach effectively shut down tumor growth. The therapy is made from a fragment of a bacterial protein, a peptide called aurB. In cancer tumors in the animal models, aurB prevented energy production in the tumor cells’ mitochondria, essentially cutting off the tumor’s fuel, the researchers report in the journal Signal Transduction and Targeted Therapy.

“The mitochondria are very important for a cell to survive; they are the energy factories,” said Tohru Yamada, senior author on the study, associate professor in the departments of surgery and biomedical engineering at UIC and a member of the University of Illinois Cancer Center. “Many cancer cells exhibit altered mitochondrial number and activity, because a cancer cell has to grow aggressively and rapidly. Therefore, the mitochondria would be an ideal target for cancer therapy.”

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