1 Department of Neurosurgery, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
2Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Nantong, China.
3Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction of T cells could disturb host–microbiota symbiosis and the physical integrity of the intestinal barrier, ultimately driving inflammageing and poor health outcomes. Finally, we propose microbiota- and T cell-based therapeutic interventions aimed at strengthening the intestinal barrier to promote healthier longevity. Namely, we discuss the transplantation of youthful microbiota, the use of designed probiotics, and the adoptive transfer of competent or engineered T cells.
Vaughan, Northwestern University Feinberg School of Medicine, Simpson Querrey Biomedical Research Center 8–516303 E. Superior St., Chicago, Illinois 60,611, USA. Phone: 312.503.1531; Email: [email protected].
~ AI supremacy & digital empires.
There is something critical taking place in the world now.
It has something to do with the neurological response system of humans.
Basically, when something happens, our sensory/nervous system processes it and guides us in the best way to respond.
That system is being blunted to death in everyone living in today’s world.
We have become so stimulated by numerous technological, socioeconomic and geopolitical shocks, that, we are almost in a helpless trance-like state now (the usual rounds of life).
We can only just watch as the world unfolds into a dystopian singularity before our eyes— wars & conflicts, natural disasters, alien disclosures, unending AI updates now laced with political & economic tensions, World Cup & UFC fevers, Stock Market volatility etc… etc…
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Superintelligence is scary, but is building it actually possible? Yes. It definitely is. To learn how you can help to secure a future where AI doesn’t kill everyone visit https://betterpathfor.ai/
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New research says time only exists where space is curved enough to support it, implying that our expanding universe is slowly losing its grip on time itself.
Dr. Roman Yampolskiy joins me to explore one of the most urgent and uncomfortable questions of our time: what happens when we create intelligence that surpasses our own? We unpack the difference between the AI tools we use today and the emergence of artificial general intelligence, and why the transition from narrow systems to self-improving intelligence may mark a point where human control is no longer possible. Roman shares why even the people building these systems do not fully understand how they work, and why that gap in understanding becomes exponentially more dangerous as capabilities increase.
In this conversation, we explore the limits of control, prediction, and safety in a world where intelligence can recursively improve itself beyond human comprehension. Roman lays out why the problem of AI alignment may be fundamentally unsolvable, what timelines experts are realistically considering, and why even a single mistake at that level could have irreversible consequences. This episode invites a deeper reflection on what we are creating, what we assume we can control, and whether humanity is prepared for the intelligence it is bringing into existence.
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André’s Book Recs: https://www.knowthyselfpodcast.com/bo… 00:00 Intro 01:25 What Is AGI and Why Should We Be Scared? 05:17 Roman’s Journey: From Optimism to Impossibility 09:07 The High Risk, Zero Reward Equation 13:01 Why Superintelligence Is Uncontrollable, Unexplainable, and Unverifiable 18:00 How Long Do We Have? The AGI Timeline 21:24 How Superintelligence Could Actually Kill Us 23:28 Are We Living in a Simulation? 28:21 Can AI Become Conscious? 31:28 Ad: BiOptimizers 32:41 The Possible Timelines: Terminator, the Matrix, or the Zoo 42:24 I-Risk, X-Risk, and S-Risk: Three Ways It Goes Wrong 46:31 The Human Meaning Crisis: Jobs, Purpose, and What’s Left 49:02 Ad: Based Bodyworks 50:20 What Empowers Us as Individuals Right Now 59:37 The Race to Doom: Who’s Building It and Why They Won’t Stop 1:07:41 Can AI Be Conscious — and Does It Already Have Internal Experiences? 1:12:41 Hacking the Simulation: Quantum, DMT, and Escaping the Code 1:18:30 Simulation Theory, Religion, and the Same Ancient Map 1:29:34 The Deal Roman Would Offer Altman, Dario, and Elon 1:39:44 What Is Humor? A Computer Scientist’s Theory 1:43:03 What Comes After: Singularity, Death, and Knowing Thyself ___________ Episode Resources: https://www.romanyampolskiy.com/ https://www.amazon.com/Unexplainable-?tag=lifeboatfound-20… / andreduqum
/ knowthyself
/ @knowthyselfpodcast https://www.knowthyselfpodcast.com Listen to the show: Spotify: https://spoti.fi/4bZMq9l Apple: https://apple.co/4iATICX
___________ 00:00 Intro 01:25 What Is AGI and Why Should We Be Scared? 05:17 Roman’s Journey: From Optimism to Impossibility 09:07 The High Risk, Zero Reward Equation 13:01 Why Superintelligence Is Uncontrollable, Unexplainable, and Unverifiable 18:00 How Long Do We Have? The AGI Timeline 21:24 How Superintelligence Could Actually Kill Us 23:28 Are We Living in a Simulation? 28:21 Can AI Become Conscious? 31:28 Ad: BiOptimizers 32:41 The Possible Timelines: Terminator, the Matrix, or the Zoo 42:24 I-Risk, X-Risk, and S-Risk: Three Ways It Goes Wrong 46:31 The Human Meaning Crisis: Jobs, Purpose, and What’s Left 49:02 Ad: Based Bodyworks 50:20 What Empowers Us as Individuals Right Now 59:37 The Race to Doom: Who’s Building It and Why They Won’t Stop 1:07:41 Can AI Be Conscious — and Does It Already Have Internal Experiences? 1:12:41 Hacking the Simulation: Quantum, DMT, and Escaping the Code 1:18:30 Simulation Theory, Religion, and the Same Ancient Map 1:29:34 The Deal Roman Would Offer Altman, Dario, and Elon 1:39:44 What Is Humor? A Computer Scientist’s Theory 1:43:03 What Comes After: Singularity, Death, and Knowing Thyself ___________.
Can AI become smarter than humans?
In this episode, I talk to Chris Summerfield about the frontier of artificial intelligence, neuroscience, LLMs, AI agents, memory, and superintelligence.
We discuss why models like ChatGPT and Claude can feel so human, why today’s AI still does not learn like the brain, and why continual learning may be one of the most important unsolved problems in AI. Chris explains how human memory works, why sleep matters for learning, and what AI research is teaching us about intelligence itself.
We also discuss the future of work, education, creativity, and whether AI could lead to a more human world — or a much stranger one.
Topics covered:
• Artificial intelligence and the human brain.
• LLMs, ChatGPT, Claude and AI agents.
• AI memory and continual learning.
• AI alignment, safety and misalignment.
• . Superintelligence and self-improving systems.
• Hallucinations, reasoning and intelligence.
• . Education, jobs and the future of work.
• . Why AI may change how humans understand themselves.
TIMESTAMPS:
Cells have surface receptors that couple to proteins and other molecules to initiate or inhibit certain behaviors. Typically, the number of these receptors increases as the cell matures, but researchers have now identified that one receptor influences cell behavior much earlier than previously thought and appears to help trigger the cell differentiation process to form neurons.
The Hiroshima University-based team published their work, which they said has implications for better understanding neuronal development and brain plasticity — and how those processes become dysregulated — on March 20 in iScience. They specifically found that G protein-coupled receptor 3 (GPR3) represents a unique molecule in this receptor family, as it behaves like an immediate-early gene that rapidly responds and induces downstream signaling. Other G protein-coupled receptors behave like delayed-response genes that aren’t expressed into much later in the cell maturation process.
Understanding early transcriptional responses — how genes are expressed in response to upstream signals — is critical because these programs determine neuronal development, synaptic formation and plasticity, and their dysregulation is associated with neurological disorders such as autism and cognitive dysfunction.