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Dr. Chris Oswald — Precision Nutrition, Epigenetics & Practitioner-Led Longevity Care

Precision Nutrition, Epigenetics & Practitioner-Led Longevity Care — Dr. Chris Oswald — Head of Medical Affairs, Pure Encapsulations, Nestlé Health Science.

Dr. Chris Oswald, DC, CNS, is Head of Medical Affairs for Pure Encapsulations (https://www.pureencapsulations.com/), part of Nestlé Health Science family. He is a chiropractor, certified nutrition specialist and certified functional medicine practitioner and has been treating patients since 2007.

At Pure Encapsulations, Dr. Oswald leads medical education, scientific strategy, and innovation across well-known professional brands including Pure Encapsulations, Douglas Labs, Klean Athlete, Genestra, and others. In this role, he sits at the intersection of clinical science, practitioner education, and product innovation — translating complex evidence into practical tools that help healthcare professionals practice more confident, personalized nutritional medicine.

Dr. Oswald’s clinical work, in combination with his work in professional dietary supplement companies, gives him unique insight into the creation of clinically useful tools and education to support the unique needs of clinicians and patients in functional, integrative and natural health.

Before joining Pure Encapsulations, Dr. Oswald held senior leadership roles across the nutraceutical and health tech landscape, including Chief Science Officer, Head of Product Innovation and R&D, Head of Operations, Interim Head of Sales, and VP of Nutraceuticals at companies like January AI and Further Food. Across those roles, he’s led everything from supply chain and regulatory strategy to product development, claims substantiation, and national practitioner education.

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Down syndrome’s unique cancer risk profile mapped across lifespan

Children with Down syndrome have a significantly increased risk of leukemia, while adults have a lower risk of several common solid tumors, according to a new register study from Karolinska Institutet published in the British Journal of Cancer. The results may contribute to more tailored cancer screening guidelines.

In a large, Swedish population-based register study, the risk of different cancer types in individuals with Down syndrome was mapped across the lifespan. The results show a markedly increased risk of leukemia during childhood, with a nearly 500-fold increased risk of acute myeloid leukemia (AML) before age 5, and a 20-fold increased risk of acute lymphoblastic leukemia (ALL). Despite this, only 2.5% of all individuals with Down syndrome developed leukemia during childhood.

In adulthood, however, a clearly reduced risk was observed for most solid tumors, including breast, prostate, lung, colorectal, and gynecological cancers, as well as melanoma. Although the study showed an overall lower cancer risk in adults, there was an increased risk of testicular cancer, as well as new associations between Down syndrome and certain rare forms of bone cancer.

Electronic informed consent in research on rare diseases sees strong participant interest

Research on rare diagnoses and the development of precision medicine depend on patients being able to share their health data in a secure and ethical manner. The research study, published in Scientific Reports, in which a digital platform was developed to collect electronic informed consent, shows that many participants want to contribute to research and appreciate the digital solution, but also that the technology needs further development.

A digital consent platform was tested at three centers in Sweden, Stockholm, Gothenburg, and Lund. More than 2,200 individuals who had previously undergone whole-genome sequencing were invited to give consent electronically for research and data sharing.

For those who lacked an electronic identity verification system, or who preferred traditional methods, paper-based consent was also available. As a comparison, a national patient cohort within Undiagnosed Diseases Network Sweden (UDN Sweden) was studied, where recruitment took place in close collaboration with patient organizations.

Sprint or marathon? Aging muscle stem cells shift from rapid repair to long-term survival

Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. A UCLA study conducted in mice reveals an unexpected cause: Stem cells in aged muscle accumulate higher levels of a protein that slows their ability to activate and repair tissue, but helps the cells survive longer in the harsh environment of aging tissue.

The findings, published today in the journal Science, suggest that some molecular changes associated with getting older may actually be protective adaptations rather than purely detrimental effects.

“This has led us to a new way of thinking about aging,” said Dr. Thomas Rando, senior author of the new study and director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

The Path to Scalable Psychiatric Gene Therapy and a Future of Cures for Widespread Mental Illnesses

Hey everyone! I wrote a proposal on creating massively scalable gene therapy delivery systems towards unlocking cures for widespread debilitating psychiatric diseases! Would love for folks to take a read and provide constructive suggestions to iterate this vision. [ https://substack.com/home/post/p-186453159]

Restoring joy to a billion lives.

Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens

Now online! Structural and functional analyses elucidate the mechanisms by which two ATP-independent RNA chaperones, Ro60 and La, recognize and unfold misfolded RNAs. Diverse noncoding RNAs are associated with this chaperone machine, supporting a wide-ranging role in maintaining RNA homeostasis.

Neurotransmission-modulated whole-brain computation captures full task repertoire

Deco et al. used neurotransmission-modulated (NEMO) whole-brain modeling to flexibly compute a broad repertoire of empirical tasks and associated neuroimaging data from 971 healthy participants. NEMO can sculpt the different brain dynamics in a fixed brain architecture to compute the rich repertoire of tasks required for surviving and thriving.

Cellular survivorship bias as a mechanistic driver of muscle stem cell aging

Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration. We uncovered a cause of this aging-associated dysfunction: a cellular survivorship bias that prioritizes stem cell persistence at the expense of functionality. With age, MuSCs increased expression of a tumor suppressor, N-myc down-regulated gene 1 (NDRG1), which, by suppressing the mammalian target of rapamycin (mTOR) pathway, increased their long-term survival potential but at the cost of their ability to promptly activate and contribute to muscle regeneration. This delayed muscle regeneration with age may result from a trade-off that favors long-term stem cell survival over immediate regenerative capacity.

New study reveals surprising side effects linked to driving electric vehicles: ‘It … has an immediate impact’

Next, the study’s authors will examine whether more ZEVs are associated with fewer asthma-related hospitalizations and emergency room visits.

Their work adds to the extensive research on whether EVs are better for the planet long-term than their gas-powered counterparts. Despite imperfections such as mining, the findings are clear on that front. The USC team is showing that when it comes to the air we breathe and public health, the benefits of EVs are undeniable.

“These findings show that cleaner air isn’t just a theory—it’s already happening in communities across California,” declared Sandrah Eckel, the study’s lead author.

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