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Lab-boosted olfactory receptor reveals new insights about how our sense of smell works

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of these ORs in lab settings—leaving them with a murky understanding of how certain smells are recognized in our brains. Only 71 human receptor-ligand interactions have been identified in studies thus far, often with low sensitivity in assays. Scientists have struggled with poor in vitro expression of ORs in lab conditions, limiting identification of receptor–odorant pairs.

In 2004, the field of olfactory science appeared to gain some progress in the form of a Nobel-winning hypothesis called the “combinatorial model,” which suggested that multiple ORs contribute to the perception of a single odorant. However, a new study, published recently in Current Biology, paints a somewhat different picture.

For their study, a group of Swiss researchers tweaked the C-terminal domains of ORs, which resulted in dramatically boosted OR cell-surface expression and sensitivity in lab conditions. This allowed the group to test out which ORs respond to various scents, like ambergris, rose, vanilla, and corked wine. Using this method, they were able to “de-orphanize” several ORs, or find matching ligands for them, resulting in novel OR identification for odorants.

Uncertainty-aware Fourier ptychography enhances imaging stability in real-world conditions

Professor Edmund Lam, Dr. Ni Chen and their research team from the Department of Electrical and Electronic Engineering under the Faculty of Engineering at the University of Hong Kong (HKU) have developed a novel uncertainty-aware Fourier ptychography (UA-FP) technology that significantly enhances imaging system stability in complex real-world environments. The research has been published in Light: Science & Applications.

Fourier ptychography, widely regarded as a cornerstone of computational imaging, enables wide field-of-view and high-resolution imaging with broad applications ranging from microscopy to X-ray and remote sensing. However, its practical implementation has long been hindered by misalignments, , and poor data quality—challenges common across computational imaging fields.

The team’s UA-FP framework innovatively incorporates uncertainty parameters into a fully differentiable computational model, enabling simultaneous system uncertainty quantification and correction and significant enhancement of imaging performance—even under suboptimal or interference-prone conditions. This advancement represents not only an advance in ptychography but also a transformative development for computational imaging as a whole.

General relativity could make life possible on planets orbiting white dwarfs

In the hunt for extraterrestrial life, we usually look for planets orbiting sun-like stars and icy moons. But there is another possible candidate—planets circling white dwarfs, the hot, dense remnants of dead stars.

A white dwarf is what is left when a star like our sun runs out of fuel and sheds its outer layers. Smaller and dimmer than they were before, these stellar remains have a habitable zone (a region where liquid water can exist on a planet’s surface) within a few million kilometers of the star, which is extremely close in astronomical terms.

While large planets have been found orbiting , scientists previously thought that life could not exist on them due to . These forces are increased when a companion planet nearby stretches the habitable planet’s orbit into an oval shape. This stretches and compresses the planet’s interior, generating frictional heat that can trigger a deadly greenhouse effect, making the planet uninhabitable. It would boil away any surface lakes and oceans and prevent life from forming.

AI streamlines search for catalysts to clear hydrogen production hurdles

To increase energy efficiency and reduce the carbon footprint of hydrogen fuel production, Fanglin Che, associate professor in the Department of Chemical Engineering at Worcester Polytechnic Institute, is leveraging the power and potential of machine learning and computational modeling. The multi-university team she leads has completed a study that was just published in Nature Chemical Engineering. The study utilized artificial intelligence to identify catalysts with the potential to facilitate cleaner and more efficient hydrogen production.

Early humans dined on giant sloths and other Ice Age giants, archaeologists find

What did early humans like to eat? The answer, according to a team of archaeologists in Argentina, is extinct megafauna, such as giant sloths and giant armadillos. In a study published in the journal Science Advances, researchers demonstrate that these enormous animals were a staple food source for people in southern South America around 13,000 to 11,600 years ago. Their findings may also rewrite our understanding of how these massive creatures became extinct.

For years, the prevailing theory about the extinction of the last great Ice Age megafauna in South America was that it was primarily due to climate change. Humans were previously believed to have played a minor role in their demise, as they hunted smaller prey, such as guanacos (a relative of the camel) and cervids (deer). However, the abundance of bones of extinct megafauna in sites studied by the team suggests that they were probably the most important food source for these .

The archaeologists counted the at 20 sites in modern-day Argentina, Chile and Uruguay. These were places that had been reliably dated to before 11,600 years ago, when these giants were still roaming around. They compared the remains of megafauna (mammals weighing over 44 kilograms) with those of smaller animals to see which were more abundant. They also closely examined the bones for cut marks and other signs that would indicate humans had butchered them.

A Promising Treatment for Leishmaniasis Found in Okinawan Marine Sponges

A family of compounds called onnamides shows remarkable potential against the parasite that causes a neglected tropical disease.

Leishmaniasis, a neglected tropical disease prevalent across 90 countries, affects approximately 12 million people worldwide, with 350 million more at risk of infection. Caused by unicellular parasites known as Leishmania protozoa, the disease commonly manifests as skin sores that can develop into deep ulcers. Beyond the physical damage to the skin, leishmaniasis can leave permanent scars on patients’ faces, hands, and feet, often leading to social stigma and psychological trauma. Unfortunately, the disease predominantly strikes poor communities, where medical care is often out of reach.

Atomic switching converts indoles to benzimidazoles in one pot, accelerating drug discovery

Scientists have achieved a new feat in molecular editing by swapping carbon for nitrogen, enabling the direct conversion of indoles into benzimidazoles. This simple switch in a one-pot method offers a hassle-free and effective way of designing medicinally relevant molecules. The work is published in Nature Chemistry.

Single-atom swap reactions require the selective formation and breaking of multiple bonds at the same time, making them quite rare and challenging.

Researchers from ETH Zurich overcame these hurdles by exploiting the electron-rich indole ring’s eagerness to undergo oxidative cleavage via Witkop oxidation. This step can split the electron-rich ring open to form a dicarbonyl intermediate, thereby creating an entry point for subsequent cascade reactions.

Nanoparticles supercharge vinegar’s old-fashioned wound healing power

Wounds that do not heal are often caused by bacterial infections and are particularly dangerous for the elderly and people with diabetes, cancer and other conditions. Acetic acid (more commonly known as vinegar) has been used for centuries as a disinfectant, but it is only effective against a small number of bacteria, and it does not kill the most dangerous types.

New research led by researchers at University of Bergen in Norway, QIMR Berghofer and Flinders University in Australia has resulted in the ability to boost the natural bacterial killing qualities of vinegar by adding antimicrobial nanoparticles made from carbon and cobalt. The findings have been published in the journal ACS Nano.

Molecular biologists Dr. Adam Truskewycz and Professor Nils Halberg found these particles could kill several dangerous bacterial species, and their activity was enhanced when added to a weak vinegar solution.

A volcano or a meteorite? New evidence sheds light on puzzling discovery in Greenland’s ice sheet

Buried deep in Greenland’s ice sheet lies a puzzling chemical signature that has sparked intense scientific debate. A sharp spike in platinum concentrations, discovered in an ice core (a cylinder of ice drilled out of ice sheets and glaciers) and dated to around 12,800 years ago, has provided support for a hypothesis that Earth was struck by an exotic meteorite or comet at that time.

Our new research published in PLOS One offers a much more mundane explanation: this mystery signature may have originated from a volcanic fissure eruption in Iceland, not space.

The timing matters. The platinum spike occurs near the beginning of our planet’s last great cold period, the Younger Dryas Event. This lasted from about 12,870 to 11,700 years ago and saw temperatures plummet across the northern hemisphere.

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