The Tara Polar Station, a $23 million research vessel with a crew of 12, will drift across the Arctic ice to enable better monitoring of a rapidly changing environment
Capitalizing on the flexibility of tiny cells inside the body’s smallest blood vessels may be a powerful spinal cord repair strategy, new research suggests.
In mouse experiments, scientists introduced a specific type of recombinant protein to the site of a spinal cord injury where these cells, called pericytes, had flooded the lesion zone. Once exposed to this protein, results showed, pericytes change shape and inhibit the production of some molecules while secreting others, creating “cellular bridges” that support regeneration of axons—the long, slender extensions of nerve cell bodies that transmit messages.
Researchers observed axon regrowth in injured mice that received a single treatment injection of the growth-factor protein, and the animals also regained movement in their hind limbs. An experiment involving human cells suggests the results are not restricted to mice.
A team of researchers from the University of Chicago, in collaboration with researchers from the University of Pittsburgh, has identified a novel oncometabolite that accumulates in tumors and impairs immune cells’ ability to fight cancer.
The study, published in Nature Cell Biology, highlights how the metabolic environment of tumors influences the function of T cells, which are critical immune cells responsible for eliminating cancer. The finding opens new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer’s disease and other neurological disorders, according to University of California, Irvine scientists. By engineering human immune cells called microglia, the researchers have created living cellular “couriers” capable of responding to brain pathology and releasing therapeutic agents exactly where needed.
The study, published in Cell Stem Cell, demonstrates for the first time that microglia derived from induced pluripotent stem cells can be genetically programmed to detect disease-specific brain changes—like amyloid plaques in Alzheimer’s disease—and then release enzymes that help break down those toxic proteins. As a result, the cells were able to reduce inflammation, preserve neurons and synaptic connections, and reverse multiple other hallmarks of neurodegeneration in mice.
For patients and families grappling with Alzheimer’s and related diseases, the findings offer a hopeful glimpse at a future in which microglial-based cell therapies could precisely and safely counteract the ravages of neurodegeneration.
A NIMS research team has developed an approach capable of accurately and rapidly predicting the degradation behavior of electrocatalysts used in water electrolyzers by employing data assimilation—a method commonly employed in weather forecasting.
After analyzing only 300 hours of experimental data, this approach accurately predicted the degradation of an electrocatalytic material occurring after approximately 900 hours of water electrolysis. This approach is able to accelerate and simplify the comparison of degradation properties among various electrocatalytic materials, potentially facilitating investigations into their degradation mechanisms and expediting the development of more efficient, economical and durable electrocatalytic materials.
The work is published in the journal ACS Energy Letters.
Six humanoid robot makers plan to produce more than 1,000 units in 2025, driving the value of domestic output to US$616 million this year.
Results of a randomized, controlled clinical trial in Japan among more than 170 children aged 1 to 6 who underwent surgery show that by using EEG readings of brain waves to monitor unconsciousness, an anesthesiologist can significantly reduce the amount of the anesthesia administered to safely induce and sustain each patient’s anesthetized state.
On average, the patients experienced significant improvements in several post-operative outcomes, including quicker recovery and reduced incidence of delirium.
“I think the main takeaway is that in kids, using the EEG, we can reduce the amount of anesthesia we give them and maintain the same level of unconsciousness,” said study co-author Emery N. Brown, Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience at MIT and an anesthesiologist at Massachusetts General Hospital. The study appears in JAMA Pediatrics.
A team of researchers at Q-CTRL, a quantum infrastructure software-maker based in Sydney, Australia, has announced the successful demonstration of its newly developed quantum navigation system called “Ironstone Opal.”
The group has written a paper describing how their system works and how well it tested against currently available backup GPS systems and has posted it on the arXiv preprint server.
With the advent and subsequent reliance on GPS by private and military vehicles and aircraft for navigation, governments have come to understand how vulnerable such systems can be. Outages can lead to drivers being stranded, pilots scrambling to use outdated systems and difficulties deploying military assets. Because of that, scientists around the world have been looking for reasonable backup systems, or even possible alternatives to GPS.
This essay advances a speculative yet empirically-grounded hypothesis: that microtubular cytoskeletal structures constitute proto-cognitive architectures in unicellular organisms, thereby establishing an evolutionary substrate for cognition that predates neural systems. Drawing upon converging evidence from molecular biology, quantum biophysics, phenomenological philosophy, and biosemiotic theory, I propose a cytoskeletal epistemology wherein cognition emerges not exclusively from neural networks, but from the dynamic, embodied information-processing capacities inherent in cellular organization itself. This framework challenges neurocentric accounts of mind while suggesting new avenues for investigating the biological foundations of knowing.
Contemporary cognitive science predominantly situates the genesis of mind within neural tissue, tacitly assuming that cognition emerges exclusively from the electrochemical dynamics of neurons and their synaptic interconnections. Yet this neurocentric paradigm, while experimentally productive, encounters both conceptual and empirical limitations when confronted with fundamental questions regarding the biological preconditions for epistemic capacities. As Thompson (2007) observes, “Life and mind share a set of basic organizational properties, and the organizational properties distinctive of mind are an enriched version of those fundamental to life” (p. 128). This suggests a profound continuity between biological and cognitive processes — a continuity that invites investigation into pre-neural substrates of cognition.
The present inquiry examines the hypothesis that the microtubule — a foundational cytoskeletal element ubiquitous across eukaryotic cells — functions not merely as mechanical infrastructure but as an evolutionary precursor to cognitive architecture, instantiating proto-epistemic capacities in unicellular and pre-neural multicellular organisms. This hypothesis emerges at the intersection of multiple research programs, including quantum approaches to consciousness (Hameroff & Penrose, 2014), autopoietic theories of cognition (Maturana & Varela, 1980), and recent advances in cytoskeletal biology (Pirino et al., 2022).
Miniature zombies are all around us, scuttling through the underbrush or flying through the air in nearly every continent on Earth. In Brazil, a fungus takes over ant brains, altering their circadian rhythms and social behaviors. In England, a virus forces caterpillars to climb high into the canopy, then slowly liquefies their bodies, which drip onto the leaves below. In Indonesia, a parasitoid wasp uses specialized venom to alter a cockroach’s brain chemistry, turning it into the perfect host for her young.
In her new book, Rise of the Zombie Bugs, self-described professional science nerd Mindy Weisberger introduces readers to a menagerie of mind-controlling parasites, and the scientists who have devoted their lives to the study of these peculiar organisms. Through these vivid tales of creatures bizarre enough to rival any fictional beast, Weisberger offers readers a peek into the fields of evolution, ecology, neuroscience, and molecular biology. She shows that these topics exist beyond dim lecture halls and dry textbooks: “Science is everything and everywhere,” she said.