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However, there are no drugs that specifically block MAPK4 that could be tested to reduce tumor growth. Instead, Yang and his colleagues explored an alternative approach.

We showed that blocking both AKT and PDK1 effectively repressed MAPK4-induced cancer cell growth, suggesting a potential therapeutic strategy to treat MAPK4-dependent cancers, such as a subset of TNBC, prostate and lung cancer.

“In this study we have not only advanced our understanding of the molecular mechanism underlying the tumor-promoting activity of MAPK4, we also have found a potential novel therapeutic approach for human cancers,” Yang said.

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Can AI capture the emotion that a singer today can convey, or dupe us into believing they’re not human? Can Ronnie James Dio’s voice be brought back from the dead? In this episode of The Singing Hole, we explore where AI’s technology is today, how creators are harnessing the technology and how we can better prepare for the eventual future with music.

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Continue reading “How long until AI can replace a singer? It’s already happening” | >

Expand your scientific horizon with Brilliant! First 200 to use our link https://brilliant.org/sabine will get 20% off the annual premium subscription.

Today I have an update on the reproduction efforts for the supposed room temperature superconductor, LK 99, the first images from the Euclid mission, more trouble with Starlink satellites, first results from a new simulation for cosmological structure formation, how to steer drops with ultrasound, bacteria that make plastic, an improvement for wireless power transfer, better earthquake warnings, an attempt to predict war, and of course the telephone will ring.

Here is the link to the overview on the LK99 reproduction experiments that I mentioned: https://urlis.net/vesb75fq.

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Continue reading “Superconductor LK99 Update” | >

US scientists have achieved net energy gain in a nuclear fusion reaction for the second time since a historic breakthrough in December last year in the quest to find a near-limitless, safe and clean source of energy.

Scientists at the California-based Lawrence Livermore National Laboratory repeated the breakthrough in an experiment in the National Ignition Facility (NIF) on 30 July that produced a higher energy yield than in December, a Lawrence Livermore spokesperson said.

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For many people, they are tiny pests. These fruit flies that sometimes hover over a bowl of peaches or a bunch of bananas. But for a dedicated community of researchers, fruit flies are an excellent model organism and source of information into how neurons self-organize during the insect’s early development and form a complex, fully functioning nervous system.

That’s the scientific story on display in this beautiful image of a larval fruit fly’s developing nervous system. Its subtext is: fundamental discoveries in the fruit fly, known in textbooks as Drosophila melanogaster, provide basic clues into the development and repair of the human nervous system. That’s because humans and fruit flies, though very distantly related through the millennia, still share many genes involved in their growth and development. In fact, 60 percent of the Drosophila genome is identical to ours.

Once hatched, as shown in this image, a larval fly uses neurons (magenta) to sense its environment. These include neurons that sense the way its body presses against the surrounding terrain, as needed to coordinate the movements of its segmented body parts and crawl in all directions.

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Cattle may seem like uniquely American animals, steeped in the lore of cowboys, cattle drives and sprawling ranches. But cattle didn’t exist on the American continents prior to the arrival of the Spanish, who brought livestock with them from Europe by way of the Canary Islands.

In a new study, researchers analyzed ancient DNA from Spanish settlements in the Caribbean and Mexico. Their results indicate were also imported from Africa early in the process of colonization, more than 100 years before their arrival was officially documented.

Records kept by Portuguese and Spanish colonists reference breeds from the Andalusian region of Spain but make no mention of transporting cattle from Africa. Some historians have interpreted this omission to mean that the first wave of colonists relied entirely on a small stock of European cattle initially shipped to the Caribbean Islands.

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