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In CRISPR-Cas and related nuclease-mediated genome editing, target recognition is based on guide RNAs (gRNAs) that are complementary to selected DNA regions. While single site targeting is fundamental for localized genome editing, targeting to expanded and multiple chromosome elements is desirable for various biological applications such as genome mapping and epigenome editing that make use of different fusion proteins with enzymatically dead Cas9. The current gRNA design tools are not suitable for this task, as these are optimized for defining single gRNAs for unique loci. Here, we introduce CRISPR-broad, a standalone, open-source application that defines gRNAs with multiple but specific targets in large continuous or spread regions of the genome, as defined by the user.

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It can take years of focused laboratory work to determine how to make the highest quality materials for use in electronic and photonic devices. Researchers have now developed an autonomous system that can identify how to synthesize “best-in-class” materials for specific applications in hours or days.

The new system, called SmartDope, was developed to address a longstanding challenge regarding enhancing called perovskite via “doping.”

“These doped quantum dots are semiconductor nanocrystals that you have introduced specific impurities to in a targeted way, which alters their optical and physicochemical properties,” explains Milad Abolhasani, an associate professor of chemical engineering at North Carolina State University and corresponding author of the paper “Smart Dope: A Self-Driving Fluidic Lab for Accelerated Development of Doped Perovskite Quantum Dots,” published open access in the journal Advanced Energy Materials.

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As the dawn of generative AI unfolds, a distinct separation will emerge among professionals and businesses: those who leverage this transformative technology to enhance productivity and innovation and those who lag behind.

Discover how adopting a generative AI mindset, blending adaptability, curiosity, and collaboration, is key to thriving in the rapidly evolving professional landscape,.

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“Our study demonstrates how telemedicine successfully integrates medical and behavioral treatment.”

The practice of providing medical services remotely via telecommunications technology is known as telemedicine.

I going to make a greatest artwork as I can, by my head, my hand and by my mind/iStock.

The practice has gained prominence, especially in response to the COVID-19 pandemic, for its ability to provide more accessible and convenient healthcare services. Now, a new study conducted on 12 opioid treatment programs is finding that it may be more successful at treating patients than more conventional approaches such as offsite referrals.

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Made using molybdenum disulfide, the processor has over 1,000 transistors but works in two dimensions.

2023 EPFL / Alan Herzog.

Modern-day information technology systems are well known for producing large amounts of heat. Heat reduction is a more efficient way of using energy and will also help the world reduce carbon emissions, as it aims to go greener in the coming few decades. To minimize this unwanted heat, one must go to the root of the problem, the von Neumann architecture.

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The impact of the research goes well beyond astronomy and can help increase accuracy of climate models as well.

Joecicak/iStock.

It is common knowledge that the Earth’s rotational axis is not entirely symmetric due to the shape of our planet. However, even the speeds at which the Earth spins are not constant. This is because out world is not completely solid and consists of solid and liquid components.

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