Lifeboat Foundation: Safeguarding Humanity
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For prospective parents who are carriers of many inherited diseases, using in vitro fertilization along with genetic testing would significantly lower health care expenditures, according to researchers at Stanford Medicine.

Preimplantation genetic diagnostic testing during IVF, or PGD-IVF, is being used to screen for single-gene defect conditions such as cystic fibrosis, sickle cell disease and Tay-Sachs disease, along with nearly 400 others.

The problem is that the high cost of IVF — and the lack of coverage by all but one state Medicaid program, that of New York — makes it unavailable to millions of people at risk. The majority of private employer health benefit plans also do not cover IVF.

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The media frenzy surrounding ChatGPT and other large, language model, artificial intelligence systems spans a range of themes, from the prosaic – large language models could replace conventional web search – to the concerning – AI will eliminate many jobs – and the overwrought – AI poses an extinction-level threat to humanity. All of these themes have a common denominator: large language models herald artificial intelligence that will supersede humanity.

But large language models, for all their complexity, are actually really dumb. And despite the name “artificial intelligence,” they’re completely dependent on human knowledge and labor. They can’t reliably generate new knowledge, of course, but there’s more to it than that.

ChatGPT can’t learn, improve or even stay up to date without humans giving it new content and telling it how to interpret that content, not to mention programming the model and building, maintaining and powering its hardware. To understand why, you first have to understand how ChatGPT and similar models work, and the role humans play in making them work.

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New research from QIMR Berghofer has found that the hormone testosterone may play an important role in the development of endometrial cancer.

The discovery raises exciting new possibilities for screening, preventing and fighting this increasingly prevalent disease.

Endometrial cancer is the fourth most common cancer in Australian women and its incidence is rising. Yet are limited, with a hysterectomy often the first line of defense.

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This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.

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In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

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Dr Ben Goertzel is a cross-disciplinary scientist, futurist, author and entrepreneur, who has spent the best part of his working life focused on creating benevolent superhuman artificial general intelligence (AGI).

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A team of geneticists and systems biologists at Stanford University has associated 169 genes that with the production of melanin in the skin, hair and eyes. In their study, reported in the journal Science, the group conducted a flow cytometry analysis and genome-wide CRISPR screen of cell samples.

Prior research has shown that the production and distribution of melanin in the body is responsible for , and eye pigmentation. Such characteristics are important for more than appearance’s sake; skin with more melanin, for example, is better able to protect against . In this new effort, the researchers noted that while many of the genes responsible for melanin production have been identified, many more have not.

The researchers began with an effort to differentiate high and low melanin melanocytes—the cells that make melanin. They used the light-reflecting properties of melanin to sort cells in a lab dish by aiming a fluorescent lamp at them. Once they had the cells sorted, they edited them using CRISPR-Cas9. Genes were systematically mutated to switch them off and then tested to see how well the cell continued to produce melanin.

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