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Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis. The question remains as to whether the chemotherapy drug docetaxel, which increases survival in metastatic prostate cancer, can improve the cure rate in these patients.

In a new study by investigators from Brigham and Women’s Hospital, a meta-analysis of five prospective randomized (RCTs) found that adding docetaxel to standard-of-care (SOC) treatment was associated with a 70% reduction in death from prostate cancer-specific mortality (PCSM). The study was published today in JAMA Network Open.

Investigators performed a of the RCTs evaluating SOC treatment with radiotherapy and androgen deprivation therapy or with versus SOC plus docetaxel. The final study cohort of 2,184 patients included 145 eligible patients (6.6%) across four eligible RCTs.

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Triple-negative breast cancer (TNBC) is an aggressive tumor with a very poor prognosis and limited therapeutic targets. Now, researchers at Baylor College of Medicine and collaborating institutions have discovered in diverse TNBC animal models that targeting the protein elF4A with the small molecule drug Zotatifin suppressed tumor cell proliferation and remodeled the tumor immune microenvironment. The findings may lead to clinical trials to assess the potential patient benefits of this novel approach.

The team published their findings in The Journal of Clinical Investigation in an article titled, “Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer.”

“Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy,” wrote the researchers. “Here, we show that therapeutically targeting the RNA helicase eIF4A by Zotatifin, the first-in-class eIF4A inhibitor, exerts pleiotropic effects on both tumor cells and the tumor immune microenvironment in a diverse cohort of syngeneic triple-negative breast cancer (TNBC) mouse models.”

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Summary: Researchers devised a machine learning model that gauges a country’s peace level by analyzing word frequency in its news media.

By studying over 723,000 articles from 18 countries, the team identified distinct linguistic patterns corresponding to varying peace levels.

While high-peace countries often used terms related to optimism and daily life, lower-peace nations favored words tied to governance and control.

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The U.S. Space Force assigned 21 rocket launches to SpaceX and United Launch Alliance, worth about $2.5 billion in total, the military branch told CNBC.

Space Force’s Space Systems Command on Tuesday announced the mission assignments, which represent the last round of orders under a multiyear program called National Security Space Launch (NSSL) Phase 2.

The final batch of assignments were split almost evenly, according to Col. Doug Pentecost, the deputy program executive officer of the Space Force’s Space Systems Command. ULA received 11 missions, valued at $1.3 billion, and SpaceX received 10 missions, valued at $1.23 billion.

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Emmett Short discusses these comments on this episode of Lifespan News.

But first, the mad scientist David Sinclair, this time with Peter Diamandis at Abundance 360, giving more details into human trials for the genetic engineering side of the technology versus the chemical and pill side of the technology. Which would you want more? We’ll also hear David’s thoughts on how AI will affect the advancement of this tech. Spoiler: A lot. I’m going to play the best parts and add my commentary along the way.

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Indian start-up Green Robot Machinery (GRoboMac) has developed a cotton picker with autonomous robotic arms, mounted on a semi-autonomous electric farm vehicle.

The robotic arms of the battery-operated machine are each capable of picking about 50 kgs cotton per day. That means that four arms, mounted on the vehicle, can pick about 200 kgs per day. High yielding farms can use additional arms, the company says.

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Continue reading “HbA1c: What’s Optimal, What’s My Data?” | >

Music for pain relief and anxiety. I think somewhere else I read it helps heal brain injuries.

Further, subject-preferred music appears to induce a superior effect in relieving pain. This can be approached by allowing participants to select the most pleasant music from a prespecified list of songs or listen to their favorite music during the study. Nevertheless, the richness of emotions, meanings, and associations involved when listening to favorite music is poorly understood, especially regarding pain relief.

About the study

In the present study, researchers evaluated which subjective aspects of listening to relaxing and favorite music were crucial for hypoalgesia. Sixty-three healthy individuals, aged 21.3, on average, participated in this study. A thermal contact probe was used to induce painful thermal stimuli on the inner forearm surface.

Continue reading “Study finds pleasurable music and ‘chills’ predict music-induced hypoalgesia” | >

When someone dies in the US, the vast majority of the time, their body is either embalmed, placed in a coffin, and buried in a cemetery, or cremated and the ashes returned to their loved ones in an urn — but those aren’t the only options.

A growing number of funeral directors, startups, and nonprofits are providing people with alternative ways to have their bodies honored after death — suggesting that the funeral landscape of tomorrow won’t be so binary.

Traditional burial and cremation has a cost for the environment, releasing chemicals into the ground or greenhouse gasses into the air, but a number of other funeral options are showing that death can be green.

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