Lifeboat Foundation: Safeguarding Humanity
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A new artificial intelligence program is helping scientists speedily sift through thousands of data sets and millions of papers to home in on genes that underly disease, drastically condensing a search process that once took months.

Using computer software, scientists can scan entire genomes, or an organism’s full set of DNA, of mice that model human diseases. The goal: to identify genetic mutations that cause those diseases and open new doors for scientists to better harness genetics to develop disease treatments, said Gary Peltz, MD, PhD, professor of anesthesiology, perioperative and pain medicine at Stanford Medicine.

But to do that, scientists must search through massive sets of genomic data, which yields more false positives than researchers care to admit. It’s also time intensive. Peltz wanted to make the genetic discovery process easier, faster and more accurate.

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The genetic code of a rare form of kidney cancer, called reninoma, has been studied for the first time. In a paper, published in Nature Communications, researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital and The Royal Free Hospital also revealed a new drug target that could serve as an alternative treatment if surgery is not recommended.

There are around 100 cases of reninoma reported to date worldwide, and it is among the rarest of tumors in humans. Although it can usually be cured with surgery, it can cause severe hypertension or it can spread and develop into metastases. There are no existing medical treatments for reninoma and management involves surgery alone. Until now, it had been unknown what genetic error causes reninoma.

In the new study, a collaboration between the Wellcome Sanger Institute and Great Ormond Street Hospital and The Royal Free Hospital, researchers found that there is a specific error in the genetic code of a known cancer gene, NOTCH1, that is behind the development of this rare cancer.

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YouTuber Lucas VRTech has designed and built a pair of finger-tracking VR gloves using just $22 in materials — and he’s released all the details on the build so others can make their own.

The challenge: We use our hands to manipulate objects in the real world, but in VR, users typically have to use controllers with buttons and joysticks.

That breaks some of the immersion, limiting the use of VR for not only gaming, but also applications like therapy and job training.

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Researchers at the Francis Crick Institute, the University of Cambridge, Imperial College London, the University of Liverpool, the University of Cape Town and UKHSA have uncovered a link between an antiviral drug for COVID-19 infections called molnupiravir and a pattern of mutations in the SARS-CoV-2 virus.

Molnupiravir works by inducing mutations in the ’s genetic information, or genome, during replication. Many of these mutations will damage or kill the virus, reducing viral load in the body. It was one of the first antivirals available on the market during the COVID-19 pandemic and was widely adopted by many countries.

In research published in Nature, the scientists used global sequencing databases to map mutations in the SARS-CoV-2 virus over time. They analyzed a family tree of 15 million SARS-CoV-2 sequences so that at each point in each virus’s evolutionary history they could see which mutations had occurred.

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A team of mechanical engineers at Nanyang Technological University in Singapore has found a way to electronically control cockroaches without injuring them. In their paper published in the journal npj Flexible Electronics, the group describes the new technology they used to remotely control the cockroaches and the benefits of doing so.

Prior research teams have created a variety of cyborg , but they all had one feature in common—they all involved attaching probes to the insect’s nervous system—procedures that led to damage to the insect, and likely some degree of pain.

In this new effort, the researchers noted that damaging cockroaches during attempts to control them results in a very short life expectancy, which then results in very little payoff for a lot of work. They also suggest such research is unethical because of the pain inflicted on the cockroaches. In this new effort, they have found a way to control cockroaches that does not involve cutting into them, resulting in a much longer lifespan.

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