Search is the brain computer interface of today, and how we access A.I. as a civilization. Let’s 🥳 democratize it.
Reconfigurable antennas—those that can tune properties like frequency or radiation beams in real time, from afar—are integral to future communication network systems, like 6G. But many current reconfigurable antenna designs can fall short: they dysfunction in high or low temperatures, have power limitations or require regular servicing.
To address these limitations, electrical engineers in the Penn State College of Engineering combined electromagnets with a compliant mechanism, which is the same mechanical engineering concept behind binder clips or a bow and arrow. They published their proof-of-concept reconfigurable compliant mechanism-enabled patch antenna today (Feb. 13) in Nature Communications.
“Compliant mechanisms are engineering designs that incorporate elements of the materials themselves to create motion when force is applied, instead of traditional rigid body mechanisms that require hinges for motion,” said corresponding author Galestan Mackertich-Sengerdy, who is both a doctoral student and a full-time researcher in the college’s School of Electrical Engineering and Computer Science (EECS). “Compliant mechanism-enabled objects are engineered to bend repeatedly in a certain direction and to withstand harsh environments.”
Amount of toxin present in wheat, which is carcinogenic when heated, can be reduced and grown, new field study confirms Toast could soon be healthier after scientists grew a field of wheat genetically-edited to remove a cancer-causing chemical. Bread, when baked, produces a dangerous toxin called acrylamide, which is believed to be carcinogenic and when toasted is even more lethal.
CRISPR has started moving out of university research laboratories and into the world of human clinical trials.
We are about to see the emergence of a new medical technology, genetic vaccines.
Is there Life on the Moons of the Outer Solar System? Research in extreme environments on Earth will help us to answer this question.
Posted on Big Think, direct weblnk at.
Posted on Big Think.
Continue reading “Is There Life on the Icy Moons of our Solar System?” »
Enhancers change rapidly during evolution, but the mechanisms by which new enhancers originate in the genome are mostly unknown. Not all regions of the genome evolve at the same rate and mutations are elevated at late DNA replication time. To understand the role played by mutational processes in enhancer evolution, we leveraged changes in mutation rates across the genome. By examining enhancer turnover in matched healthy and tumor samples in human individuals, we find while enhancers are most common in early replicating regions, new enhancers emerged more often at late replicating regions. Somatic mutations in cancer are consistently elevated in enhancers that have experienced turnover compared to those that are maintained. A similar relationship with DNA replication time is observed in enhancers across mammalian species and in multiple tissue-types. New enhancers appeared almost twice as often in late compared to early replicating regions, independent of transposable elements. We trained a deep learning model to show that new enhancers are enriched for mutations that modify transcription factor (TF) binding. New enhancers are also typically neutrally evolving, enriched in eQTLs, and are more tissue-specific than evolutionarily conserved enhancers. Accordingly, transcription factors that bind to these enhancers, inferred by their binding sequences, are also more recently evolved and more tissue-specific in gene expression. These results demonstrate a relationship between mutation rate, DNA replication time and enhancer evolution across multiple time scales, suggesting these observations are time-invariant principles of genome evolution.
The authors have declared no competing interest.
Well that’s one way to make good use of the space.
If we have vertical farms then why not vertical pig farms.
High-rise hog farms have sprung up nationwide as part of Beijing’s drive to enhance its agricultural competitiveness and reduce its dependence on imports.
Continue reading “China’s Bid to Improve Food Production? Giant Towers of Pigs” »
Hybrid.
Coolest stuff on the planet. Interesting posts/articles about Earth – nature, animals, geography, science, history and more.
Where do the world’s major earthquakes happen? This map highlights the epicenters of earthquakes on record between 1956 and 2022.
Enhancers change rapidly during evolution, but the mechanisms by which new enhancers originate in the genome are mostly unknown. Not all regions of the genome evolve at the same rate and mutations are elevated at late DNA replication time. To understand the role played by mutational processes in enhancer evolution, we leveraged changes in mutation rates across the genome. By examining enhancer turnover in matched healthy and tumor samples in human individuals, we find while enhancers are most common in early replicating regions, new enhancers emerged more often at late replicating regions. Somatic mutations in cancer are consistently elevated in enhancers that have experienced turnover compared to those that are maintained. A similar relationship with DNA replication time is observed in enhancers across mammalian species and in multiple tissue-types. New enhancers appeared almost twice as often in late compared to early replicating regions, independent of transposable elements. We trained a deep learning model to show that new enhancers are enriched for mutations that modify transcription factor (TF) binding. New enhancers are also typically neutrally evolving, enriched in eQTLs, and are more tissue-specific than evolutionarily conserved enhancers. Accordingly, transcription factors that bind to these enhancers, inferred by their binding sequences, are also more recently evolved and more tissue-specific in gene expression. These results demonstrate a relationship between mutation rate, DNA replication time and enhancer evolution across multiple time scales, suggesting these observations are time-invariant principles of genome evolution.
