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A new twist on a decades-old anticancer strategy has demonstrated significant potential against various cancer types in a preclinical study conducted by researchers at the Perelman School of Medicine at the University of Pennsylvania

The University of Pennsylvania (Penn) is a prestigious private Ivy League research university located in Philadelphia, Pennsylvania. Founded in 1740 by Benjamin Franklin, Penn is one of the oldest universities in the United States. It is renowned for its strong emphasis on interdisciplinary education and its professional schools, including the Wharton School, one of the leading business schools globally. The university offers a wide range of undergraduate, graduate, and professional programs across various fields such as law, medicine, engineering, and arts and sciences. Penn is also known for its significant contributions to research, innovative teaching methods, and active campus life, making it a hub of academic and extracurricular activity.

Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+.

Looking for a new way to boost enzymes

The researchers begin their paper by noting that most drugs administered to people are geared towards inhibition of particular enzymes in order to treat a disease. In this case, however, the goal is the opposite: to boost the function of an enzyme, thereby boosting a healthy phenotype rather than battling back a diseased one.

Summary: A study analyzing data from over 2 million veterans found that GLP-1 receptor agonists, popular weight-loss drugs like Ozempic and Wegovy, provide significant neurological and behavioral health benefits, including reduced risks of addiction, Alzheimer’s, and dementia. However, they also pose risks for pancreatitis and kidney conditions, emphasizing the need for careful monitoring.

The drugs mimic hormones that curb appetite and aid weight loss but may act on brain regions tied to impulse control and inflammation, explaining their broad effects. Researchers stress that while the benefits are modest, they may be impactful for conditions with limited treatment options, highlighting both their potential and limitations.

A new way of interpreting standard blood tests could help doctors spot cancer warning signs sooner, according to scientists.

Experts believe it could flag 10,000 patients a year who have a raised blood platelet count before their cancer diagnosis — leading to ‘earlier diagnosis and better patient outcomes’

Groundbreaking research uses brain stimulation to restore touch in prosthetics. Precise, stable sensations bring natural-like feedback closer, improving motor control and quality of life.


Summary: Researchers are making strides in restoring touch sensations to prosthetic limbs through brain stimulation. By using electrodes in the brain’s touch center, they can evoke stable, precise sensations, even allowing users to feel the shape and motion of objects.

This breakthrough could enable prosthetic users to perform tasks requiring fine motor control with confidence. Long-term tests show consistent sensation locations, critical for real-world usability.

Advanced stimulation patterns further enhance the tactile experience, mimicking natural touch. These innovations mark significant progress toward neuroprosthetics that improve quality of life for people with limb loss or sensory impairments.

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