Stanford Medicine researchers, after creating an AI-based algorithm to find complex structural variants in the human genome, learned those variants likely contribute to psychiatric disease.
UC Berkeley’s tiny, bee-inspired flying robot weighs 21 mg, hovers, and hits targets using magnetic fields for potential rescue missions.
Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid, research reveals
Posted in asteroid/comet impacts, existential risks | Leave a Comment on Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid, research reveals
More mammals were living on the ground several million years before the mass extinction event that wiped out the dinosaurs, new research led by the University of Bristol has revealed.
The study, published in the journal Palaeontology, provides fresh evidence that many mammals were already shifting toward a more ground-based lifestyle leading up to the asteroid’s impact.
By analyzing small-fossilized bone fragments, specifically end of limb bones, from marsupial and placental mammals found in Western North America—the only place with a well-preserved terrestrial fossil record from this time—the team discovered signs that these mammals were adapting to life on the ground. End of limb bones were analyzed as they bear signatures of locomotory habit that can be statistically compared with modern mammals.
Non-ICANS neurological complications after CAR T-cell therapies: recommendations from the EBMT Practice Harmonisation and Guidelines Committee
Posted in biotech/medical | Leave a Comment on Non-ICANS neurological complications after CAR T-cell therapies: recommendations from the EBMT Practice Harmonisation and Guidelines Committee
Neurological complications are an important concern in patients undergoing chimeric antigen receptor (CAR) T-cell therapy. Consensus guidelines inform the management of immune effector cell-associated neurotoxicity syndrome (ICANS). However, these guidelines are based on the early clinical experience with CD19 targeting CAR T cells in B-cell malignancies. In contrast, there are so far no published best practice recommendations on the current management of other non-classical neurological complications, which frequently develop after CAR T-cell infusion and cause clinically significant neurotoxicity.
Immunotherapies, predominantly immune-checkpoint inhibitors and chimaeric antigen receptor T cells, have transformed oncology. Nonetheless, these systemically administered agents have several limitations, including the risk of off-target toxicities and a lack of activity owing to an inability to overcome an immunosuppressive tumour microenvironment (TME). In this Review, the authors describe the potential to overcome these challenges using functionalized nanomaterials that are designed to release a wide range of immunotherapeutic cargoes in response to specific TME characteristics, including hypoxia, differences in pH, the presence of specific enzymes, reactive oxygen species and/or high levels of extracellular ATP.
Keenon Robotics unveils XMAN-R1 humanoid and new KLEENBOT robots, advancing automation in hospitality and service industries.
Everything is bigger in Texas — including a new housing development with a futuristic vision.
Icon, a 3D technology company, is behind dozens of next-generation 3D-printed homes in the Lone Star State. A YouTube video gives viewers an inside look at the new homes built with robotic construction at the Wolf Ranch development in Georgetown.
A Science Advances study proposes cells may process information using quantum mechanisms far faster than classical biochemical signaling.
LA JOLLA—Human bodies defend themselves using a diverse population of immune cells that circulate from one organ to another, responding to everything from cuts to colds to cancer. But plants don’t have this luxury. Because plant cells are immobile, each individual cell is forced to manage its own immunity in addition to its many other responsibilities, like turning sunlight into energy or using that energy to grow. How these multitasking cells accomplish it all—detecting threats, communicating those threats, and responding effectively—has remained unclear.
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