Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 2526

Approximately 2,000 years ago in ancient Rome, glass containers filled with wine, water, or possibly exotic perfumes, fell off a marketplace table, breaking into countless pieces on the ground. Over the ensuing centuries, these shards became buried under layers of dirt and debris and exposed to a continuous cycle of changes in temperature, moisture, and surrounding minerals.

Now these tiny pieces of glass are being uncovered from construction sites and archaeological digs and reveal themselves to be something extraordinary. On their surface is a mosaic of iridescent colors of blue, green, and orange, with some displaying shimmering gold-colored mirrors.

These beautiful glass artifacts are often set in jewelry as pendants or earrings, while larger, more complete objects are displayed in museums.

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In the early hours of October 24, 2023, the southern peak of Sakurajima roared, dramatically punctuating the Kagoshima City skyline. The volcanic eruption, Japan’s second-largest this year, sent a plume of smoke spiraling 3,400 meters above the crater. This follows another eruption on October 19, which reached an even greater height of 3,600 meters. A Spectacle of Fire and Lightning The eruption was not just a spectacle of fire and smoke…

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Stress may enhance the brain’s ability to encode and store memory, a new Yale study finds.

A team led by Yale Department of Psychiatry’s Elizabeth Goldfarb, PhD, found study participants were more able to remember specific pairings of images after taking cortisol, a key stress hormone.

“We discovered this pathway where cortisol is helping the hippocampus talk to itself, and that helps people remember emotional experiences better,” Goldfarb says.

The hippocampus is a key brain region involved in encoding memory. Cortisol boosts connectivity in this region to enhance memory, according to Yale researchers.

Continue reading “Stress Amplifies the Brain’s Ability to Encode Memory, New Study Finds” | >

Year 2013 I believe I have seen maybe we are actually in a sorta matrix due to holographic quantum fluid that is throughout reality much like the fabric of the universe but is actually a permeable membrane of reality of quantum fluid. This article details that fluidity of water mimics near all quantum mechanics which would then show then reality may be a holographic quantum fluid as well.

MIT researchers expand the range of quantum behaviors that can be replicated in fluidic systems, offering a new perspective on wave-particle duality.

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It has become nearly impossible for human researchers to keep track of the overwhelming abundance of scientific publications in the field of artificial intelligence and to stay up-to-date with advances.

Scientists in an international team led by Mario Krenn from the Max-Planck Institute for the Science of Light have now developed an AI algorithm that not only assists researchers in orienting themselves systematically but also predictively guides them in the direction in which their own research field is likely to evolve. The work was published in Nature Machine Intelligence.

In the field of artificial intelligence (AI) and (ML), the number of is growing exponentially and approximately doubling every 23 months. For human researchers, it is nearly impossible to keep up with progress and maintain a comprehensive overview.

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Stupendous paper on a new spatial transcriptomic atlas of mouse brain by Shi et al. from Xiao Wang’s group at MIT. They leverage their in situ sequencing method “STARmap PLUS” to profile 1,022 genes in 3D and map 1.09 million cells across the adult mouse brain and spinal cord. While they did not use the whole brain, instead opting for a series of thick sections at regular intervals, they still covered a lot of ground! Furthermore, they employed graph-theoretic computational methods to predict wider gene expression profiles of cells in their dataset, imputing single-cell expression profiles of 11,844 genes. This dataset/resource will serve the neurobiology community in elucidating the mechanistic workings of the brain!

In situ spatial transcriptomic analysis of more than 1 million cells are used to create a 200-nm-resolution spatial molecular atlas of the adult mouse central nervous system and identify previously unknown tissue architectures.

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Next generation sequencing is now essential for patients with metastatic biliary cancer given the identification of targetable pathways, including fibroblast growth factor receptor and isocitrate dehydrogenase 1, for which there are approved treatments. HER2 has emerged as a target in metastatic biliary cancer, with studies finding 5% to 15% of cancers positive for overexpression or gene amplification.

Investigators now report results of an industry-sponsored, phase 2 basket study (SGNTUC-019) testing the combination of tucatinib — a HER2 tyrosine kinase inhibitor — and trastuzumab in patients with HER2-positive advanced biliary cancer that progressed on first-line gemcitabine/cisplatin–based chemotherapy. Local testing for HER2 was permissible via immunohistochemistry, fluorescence in situ hybridization, or next generation sequencing of tissue or blood.

Of 30 patients, half were men, 77% were Asian, half had gallbladder primaries, and half had intrahepatic or extrahepatic cholangiocarcinomas. During a median follow-up of 10.8 months, the primary endpoint of antitumor response rate was 46.7%, and duration of response was 6 months. The median progression-free survival was 5.5 months; median overall survival was 15.5 months. Treatment-related grade 3 or 4 serious adverse events were uncommon and attributable to tucatinib in 10% of patients and to trastuzumab in 6.7%; grade 3 diarrhea occurred in 6.6%.

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