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Engineered immune cells have demonstrated great efficacy in lymphoma but not in solid tumors. On Oct 13th, 2021, two experts described recent advances in the development of CAR therapy for solid tumors.

Tamara Laskowski, PhD, Scientific Project Director of the CAR NK Program, Adoptive Cell Therapy Platform at the MD Anderson Cancer Center discussed “Engineering off-the-shelf CAR immune cells”.

Maik Luu, PhD, Project Principal Investigator at the University Hospital Würzburg, presented her results on “Improving CAR T therapy efficacy with the gut microbiome”.

BPS Bioscience CAR T-Cell Therapy Products: https://bpsbioscience.com/research-areas/car-t.

The Lung Cancer Webinar Series Presentation held on August 31, 2022 on “Treatment of Unresectable Stage 3 Non-Small Cell Lung Cancer” moderated by: Hatim Husain, M.D., Medical Oncologist, Associate Professor of Medicine, UC San Diego Health and discussants: Edward B. Garon, M.D., MS, Professor of Medicine at David Geffen School of Medicine, UCLA Department of Medicine, Division of Hematology/Oncology and Aaron E. Lisberg, M.D., Assistant Clinical Professor at David Geffen School of Medicine, UCLA Department of Medicine, Division of Hematology/Oncology.

To address the long-standing debate about whether a massive asteroid impact or volcanic activity caused the extinction of dinosaurs and numerous other species 66 million years ago, a team at Dartmouth College took an innovative approach — they removed scientists from the debate and let the computers decide.

The researchers report in the journal Science a new modeling method powered by interconnected processors that can work through reams of geological and climate data without human input. They tasked nearly 130 processors with analyzing the fossil record in reverse to pinpoint the events and conditions that led to the Cretaceous –Paleogene (K–Pg) extinction event that cleared the way for the ascendance of mammals, including the primates that would lead to early humans.

Summary: Researchers have discovered new insights into persistent aggression in female fruit flies, challenging existing theories.

A new study shows that certain neural cells sustain aggressive behavior for up to 10 minutes, suggesting factors beyond recurrent neural connections are at play.

These findings could aid understanding of human aggression and related neurological conditions, highlighting the need for revised models of aggression in the brain.

Optical wireless may no longer have any obstacles. A study by Politecnico di Milano, conducted together with Scuola Superiore Sant’Anna in Pisa, the University of Glasgow and Stanford University, and published in Nature Photonics, has made it possible to create photonic chips that mathematically calculate the optimal shape of light to best pass through any environment, even one that is unknown or changing over time.

The problem is well known: light is sensitive to any form of obstacle, even very small ones. Think, for example, of how we see objects when looking through a frosted window or simply when our glasses get foggy. The effect is quite similar on a beam of light carrying in optical wireless systems: the information, while still present, is completely distorted and extremely difficult to retrieve.

The devices developed in this research are small silicon chips that serve as smart transceivers: working in pairs, they can automatically and independently ‘calculate’ what shape a needs to be in order to pass through a generic environment with . And that’s not all: they can also generate multiple overlapping beams, each with its own shape, and direct them without them interfering with each other; in this way, the transmission capacity is significantly increased, just as required by next-generation wireless systems.

Summary: New research reveals the cerebellum’s significant role in the evolution of human cognitive functions. The study mapped the genetic development of cerebellar cells in humans, mice, and opossums, uncovering both ancestral and unique cellular characteristics.

Key findings include the increased proportion of specific Purkinje cells in humans, potentially linked to higher cognitive functions, and the identification of over 1,000 genes with varying activity profiles across species, some related to neurodevelopmental disorders.