Lifeboat Foundation: Safeguarding Humanity
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Groundbreaking research led by a global group of over 100 researchers will enable a more in-depth exploration of human genetic variation as fully sequencing the Y chromosome, a feat that has challenged scientists for years, has been accomplished for the first time. In this interview, we speak to Dylan Taylor about this impactful research and how it may shape our understanding of human genetics.

Please could you introduce yourself and your current research activities?

I am Dylan Taylor, a Ph.D. candidate and NIH F31 fellow in the Department of Biology at Johns Hopkins University. My work with the T2T consortium focuses on exploring how a complete reference genome can improve our ability to study human genetic variation and how it impacts human traits and health.

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Polyploidization-rediploidization process plays an important role in plant adaptive evolution. Here, the authors assemble the genomes of mangrove species Sonneratia alba and its inland relative Lagerstroemia speciosa, and reveal genomic evidence for rediploidization and adaptive evolution after the whole-genome triplication.

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I have written a lot about vaccines that treat cancer. Now we have another new mRNA vaccine to treat pancreatic cancer that has shown promising results in phase 1 clinical trials and is now entering a larger phase 2 clinical trial. This is exciting news for a deadly cancer that attacks tens of thousands of people each year.

The mRNA vaccine technology is going to be one of the leading technologies for cancer treatments going forward. If it can make a meaningful dent in the course of pancreatic cancer, it may well become one of the primary tools for oncologists in treating this pernicious disease.

As I usually do, let’s review this vaccine and the clinical trial results.

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A new study published in Nature Astronomy describes the most luminous object ever observed by astronomers. It is a black hole with a mass of 17 billion Suns, swallowing a greater amount of mass than the sun every single day.

It has been known about for several decades, but since it is so bright, astronomers assumed it must be a nearby star. Only recent observations revealed its extreme distance and luminosity.

The object has been dubbed J0529-4351. This name simply refers to its coordinates on the celestial sphere—a way of projecting the objects in the sky onto the inside of a sphere. It is a type of object called a quasar.

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Physicists at Paderborn University have enhanced solar cell efficiency significantly using tetracene, an organic material, based on complex computer simulations. They discovered that defects at the tetracene-silicon interface boost energy transfer, promising a new solar cell design with drastically improved performance.

Physicists at Paderborn University have used complex computer simulations to create a novel solar cell design that boasts substantially higher efficiency than existing options. The enhancement in performance is attributed to a slender coating of an organic compound named tetracene. The results have recently been published in the renowned journal Physical Review Letters.

“The annual energy of solar radiation on Earth amounts to over one trillion kilowatt-hours and thus exceeds the global energy demand by more than 5,000 times. Photovoltaics, i.e. the generation of electricity from sunlight, therefore offers a large and still largely untapped potential for the supply of clean and renewable energy. Silicon solar cells used for this purpose currently dominate the market, but have efficiency limits,” explains Prof Dr Wolf Gero Schmidt, physicist and Dean of the Faculty of Natural Sciences at Paderborn University. One reason for this is that some of the energy from short-wave radiation is not converted into electricity, but into unwanted heat.

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