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Berkshire Hathaway said on Tuesday it has shed its holdings in General Motors and Procter & Gamble, and trimmed its stake in Amazon.com, as the conglomerate controlled by billionaire Warren Buffett boosted its cash pile to a record $157.2 billion.

In a regulatory filing detailing its U.S.-listed stock holdings as of Sept. 30, Berkshire reported no holdings in GM and P&G, after reporting stakes of $848 million and $48 million in June, and said it reduced its stake in Amazon by 5%.

Berkshire also appeared to have shed what had been a $621 million stake in Celanese, a specialty materials company.

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As a result, he’s built a network of peers who can relate to his challenges, name-dropping Spotify CEO Daniel Ek, who had appeared on the same podcast just a few weeks before, as one of them.

“Daniel Ek doesn’t know the Brian before Airbnb,” Chesky explained. “So maybe he doesn’t know ‘the real me’…but he does know a different ‘real me’ that my childhood friends can’t know, because high school and college friends can’t possibly know what it’s like for me to go through what I’m going through.

I can tell it to them, and they can have compassion, but they can’t possibly know what I’m talking about. But Daniel can.

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The afterlife Jones made.

For as long as we have had history and likely before, people have contemplated a life after this one, but might we one day create artificial afterlives? And if so, will we create heavens or hells?\
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Credits:\
Artificial Afterlives \
Science \& Futurism with Isaac Arthur\
Episode 399, June 15, 2023\
Written, Produced \& Narrated by Isaac Arthur\
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Editors:\
Dillon Olander\
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Graphics by: \
Jeremy Jozwik\
Ken York\
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Music Courtesy of\
Markus Junnikkala, \

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Europe’s health regulator followed the US and UK in backing the first gene-editing therapy to use Crispr technology, a Vertex Pharmaceuticals Inc. and Crispr Therapeutics AG treatment for sickle cell disease.

The European Medicines Agency’s expert panel recommended on Friday authorizing the Vertex and Crispr drug, Casgevy, for people with severe sickle cell disease and another serious hereditary blood disorder, beta-thalassemia, which is traditionally treated with repeated transfusions. Vertex said before the ruling that it had yet to establish a European list price for the one-time therapy, which costs $2.2 million in the US.

The treatment makes precisely targeted changes in patients’ DNA, a months-long process that requires removing bone marrow and a stem cell transplant. In Europe, Vertex said its initial focus will be on countries with the highest numbers of patients, including France, Italy, the UK and Germany.

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Artificial intelligence researchers claim to have made the world’s first genuine scientific discovery using a large language model (LLM), which is behind ChatGPT and similar programs. This signals a major breakthrough.

The discovery was made by Google DeepMind, an AI research laboratory where scientists are investigating whether LLMs can do more than just repackage information learned in training and actually generate new insights.

It turns out that they can, and the implications are potentially huge. DeepMind said in a blog post that its FunSearch, a method to search for new solutions in mathematics and computer science, made “the first discoveries in open problems in mathematical sciences using LLMs.”

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ABSTRACT: Optogenetics has been widely expanded to enhance or suppress neuronal activity and it has been recently applied to glial cells. Here, we will discuss about a novel approach based on selective expression of melanopsin, a G-protein-coupled photopigment, in astrocytes. We will show the selective expression of melanopsin in astrocytes allows triggering astrocytic Ca2+ signalling, but also studying astrocyte–neuron networks and the behavioral astrocytic contribution.\

Chair and introduction: Dr. Letizia Mariotti (CNR — Institute of Neuroscience)

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