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NASA’s spacecraft Juno just had a super-close encounter with the most volcanic world in the solar system—but its stunning first image could be among its last after 56 orbits of Jupiter.

On December 30, the bus-sized spacecraft—orbiting Jupiter since 2016—got very close to Io, the giant moon of Jupiter. It reached a mere 930 miles (1,500 kilometers) from the moon’s surface. However, the spacecraft’s camera has suffered radiation damage and may not last much longer.

The first image to come back from this, the closest pass since NASA’s Galileo probe imaged the volcanic moon in October 2001, was published on social media by NASA on December 31. “The JunoCam instrument aboard our Juno Mission acquired six images of Jupiter’s moon Io during its close encounter today,” read the tweet. “This black-and-white view was taken at an altitude of about 1,500 miles (2,500 kilometers).”

Every year I compile what I think were some important contributions to longevity research. Here is my list for 2023.\
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Find me on Twitter — / eleanorsheekey \
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Intro — 00:00\
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What causes aging? — 00:32\
Hallmarks Of Aging: An Expanding Universe \
The DREAM Complex Functions As Conserved Master Regulator Of Somatic DNA-Repair Capacities \
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Biomarkers — 02:00\
The Aging Biomarker Consortium Represents A New Era For Aging Research In China\
Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock\
A Foundation Model For Generalizable Disease Detection From Retinal Images\
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Cellular reprogramming — 04:30\
Chemically induced reprogramming to reverse cellular aging\
Loss of epigenetic information as a cause of mammalian aging\
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure\
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Lifespan extension — 07:30\
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used\
Taurine deficiency as a driver of aging\
Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice\
Optogenetic Rejuvenation Of Mitochondrial Membrane Potential Extends C. Elegans Lifespan\
Reversal Of Biological Age In Multiple Rat Organs By Young Porcine Plasma Fraction\
Multi-Omic Rejuvenation And Life Span Extension On Exposure To Youthful Circulation\
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Biotechnology — 13:50\
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues\
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy\
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Why we age — 15:15\
Ageing as a software design flaw\
The Longevity Bottleneck Hypothesis: Could Dinosaurs Have Shaped Ageing In Present‐Day Mammals?\
Reconsidering Life History Theory Amid Infectious Diseases\
Blood Group A Enhances SARS-CoV-2 Infection\
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What’s next? — 16:50\
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There are many items missing from this list — these are only the papers I found time to read. Please post below any I missed! \
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ICYMI\
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2022 longevity papers\
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2021 longevity papers\
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Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.\
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Icons in intro; \.

The Effective Accelerationism movement — a staunchly pro-AI ideology that has Silicon Valley split over how artificial intelligence should be regulated — appears to be walking a razor’s edge between being a techno-libertarian philosophy and a nihilistic, even reckless, approach to advancing one of…


Silicon Valley’s new ideological faction, called Effective Accelerationism or e/acc, is focused on the pursuit of AI development with no guardrails to slow its growth.