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Genome editing enables mice to produce their own weight-loss drug for months

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

In the study, “Targeted In Vivo Gene Integration of a Secretion-Enabled GLP-1 receptor agonist Reverses Diet-induced Non-genetic Obesity and Pre-diabetes,” published in Communications Medicine, researchers from the University of Osaka reveal a modified genome editing approach to tackle noncommunicable, multifaceted diseases.

The approach introduced a new protein-coding gene, rather than attempting to correct a mutation in an existing gene and could be the key to lifelong effective weight management.

Universal stem cells reset immunity in a systemic sclerosis patient

Research led by Naval Medical University’s Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis.

Systemic sclerosis progressively suffocates tissue through immune misfires, collapsed micro-vessels, and runaway collagen conditions that resist standard immunosuppressants, biologics, and anti-fibrotic drugs while driving a 40% 10-year mortality.

Cell-based approaches such as hematopoietic-stem-cell transplants and CAR-T therapies have shown promise but carry high toxicity or labor-intensive custom manufacturing, leaving clinicians and patients in search of safer, more accessible tools.

Ancient bone-eating worms ate mosasaur, ichthyosaur and plesiosaur skeletons

When large marine animals like whales die, they sink down to the seabed. Once their flesh has been stripped away by scavengers and microbes, their corpses are colonized by a variety of specialized invertebrates that feast on the fats and proteins locked inside their skeletons.

Helicobacter pylori eradication and gastric cancer prevention in a pooled analysis of large-scale cohort studies in Japan

Helicobacter pylori (H. pylo ri) infection is an established cause of gastric cancer. Although H. pylo ri eradication is suggested to decrease gastric cancer risk, this has not been fully investigated in general populations. This analysis included 48,530 Japanese men and women aged 40–74 years from four cohort studies. At baseline, the participants provided a self-reported eradication history and serum anti–H. pylo ri IgG titers and the results of a pepsinogen (PG) test. We examined the association between eradication history and gastric cancer risk considering H. pylo ri positivity and PG testing using Cox proportional hazards regression models. From 2010 to 2,018,649 gastric cancer cases were diagnosed. Compared with those who were negative for both H. pylo ri and PG test as a reference, gastric cancer risk was 5.89 times higher (95%CI: 4.41–7.87) in those who were H. pylo ri-positive and/or PG test-positive and with no eradication at baseline. Gastric cancer risk among those who underwent eradication before baseline decreased after a temporal increase in risk following eradication (baseline to 1y: HR 1.74, 95%CI 1.18–2.57; 1y to Ono, A., Tanaka, S., Sawada, N. et al. Sci Rep 15, 21,307 (2025). https://doi.org/10.1038/s41598-025-00713-z.

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What It’s Like Using a Brain Implant With ChatGPT

The potential of chat gpt and neural link is limitless. Really chat gpt with agi would automate even an entire world and even do all work by itself basically taking the forever mental labor of work forever scenario away from humans so we can sit and drink tea or other leisure activities. Then if we miniaturize even chat gpt, neural link, and agi all in one whether it is in the neural link or even on a smartphone it could allow for near infinite money 💵 with little to no effort which takes away mental labor forever because we could solve anything or do all jobs with no need for even training it would be like an everything calculator for an eternity of work so no humans need suffer the dole of forever mental labor which can evolve earths civilization into complete abundance.

We spoke to two people pioneering ChatGPT’s integration with Synchron’s brain-computer-interface to learn what it’s like to use and where this technology is headed.

Read more on CNET: How This Brain Implant Is Using ChatGPT https://bit.ly/3y5lFkD

0:00 Intro.
0:25 Meet Trial Participant Mark.
0:48 What Synchron’s BCI is for.
1:25 What it’s like to use.
1:51 Why work with ChatGPT?
3:05 How Synchron’s BCI works.
3:46 Synchron’s next steps.
4:27 Final Thoughts.

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