From brain implants that allow paralyzed patients to communicate to the wearable devices enhancing our capabilities, brain-computer interfaces could change the way we use our minds forever. (Source: Bloomberg)
A viral video featuring a woman who credits sour sop leaves, apricot seeds, and dietary changes for overcoming stage 4 metastatic breast cancer has ignited widespread discussion on social media.
Originally shared by Super Food Mood on Instagram, the video has amassed significant traction, drawing both support and skepticism.
A Survivor’s Testimony
In this edition, we’ll take a look at a Canadian study which shows that reducing a worm’s ability to fight free radicals in a specific organ could increase it’s lifespan. Does this have any implications for humans?
Contents:
Intro 0:00
Graphical Abstract 1:49
Figure 1. Tissue-specific re-expression of sod-2 rescues deficits in fertility and embryonic lethality in clk-1;sod-2 mutants 2:28
Figure 2. Tissue-specific re-expression of sod-2 can decrease stress resistance in clk-1;sod-2 worms 5:37
Figure 3. Tissue-specific re-expression of sod-2 is not sufficient to reduce clk-1;sod-2 lifespan 6:41
Figure 4. Disruption of mitochondrial superoxide dismutase in the intestine is sufficient to increase lifespan 7:33
Figure 5. Intestine-specific knockdown of sod-2 is sufficient to enhance resistance to heat stress 9:33
Figure 6. Intestine-specific knockdown of sod-2 does not affect physiologic rates 10:29
Conclusion & Next Steps 11:40
Study reviewed:
Introducing a new weekly video series showcasing the latest impactful longevity related studies.
” +Study reviewed: Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.
A new weekly series showcasing the latest and most impactful longevity studies.
Reviewing a trial where young blood plasma was used during joint replacement surgery in older adults, reducing immune system related inflammation and speeding up recovery. This is one of the first human trials of young plasma after many positive results in mice.
Contents:
Intro 0:00
Study Overview 1:07
Proteomic Changes 1:45
Immune Response 3:07
Specific Immune Cell Changes 4:22
Patient Outcomes 6:09
Conclusion 7:44
Study reviewed:
Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk
Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
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Longevity Snapshot #5 — Reviewing a trial which shows that a combination of Omega 3, Vitamin D and Exercise slows down biological aging in older adults according to 4 epigenetic clocks.
Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive protective effect of omega-3, vitamin D and exercise using PhenoAge.
For over a century, physicists have grappled with one of the most profound questions in science: How do the rules of quantum mechanics, which govern the smallest particles, fit with the laws of general relativity, which describe the universe on the largest scales?
The optical lattice clock, one of the most precise timekeeping devices, is becoming a powerful tool used to tackle this great challenge. Within an optical lattice clock, atoms are trapped in a “lattice” potential formed by laser beams and are manipulated with precise control of quantum coherence and interactions governed by quantum mechanics.
Simultaneously, according to Einstein’s laws of general relativity, time moves slower in stronger gravitational fields. This effect, known as gravitational redshift, leads to a tiny shift of atoms’ internal energy levels depending on their position in gravitational fields, causing their “ticking”—the oscillations that define time in optical lattice clocks—to change.
Astronomers have discovered strong evidence for the closest supermassive black hole outside of the Milky Way galaxy. This giant black hole is located in the Large Magellanic Cloud, one of the nearest galactic neighbors to our own.
To make this discovery, researchers traced the paths with ultra-fine precision of 21 stars on the outskirts of the Milky Way. These stars are traveling so fast that they will escape the gravitational clutches of the Milky Way or any nearby galaxy. Astronomers refer to these as “hypervelocity” stars.
Similar to how forensic experts recreate the origin of a bullet based on its trajectory, researchers determined where these hypervelocity stars come from. They found that about half are linked to the supermassive black hole at the center of the Milky Way. However, the other half originated from somewhere else: a previously-unknown giant black hole in the Large Magellanic Cloud (LMC).
A phone screen you can’t scratch no matter how many times you drop it; glasses that prevent glare; a windshield that doesn’t get dusty. These are all possibilities thanks to a new way to produce sapphire.
Researchers at The University of Texas at Austin have discovered techniques to bestow superpowers upon sapphire, a material that most of us think of as just a pretty jewel. But sapphire is seen as a critical material across many different areas, from defense to consumer electronics to next-generation windows, because it’s nearly impossible to scratch.
“Sapphire is such a high-value material because of its hardness and many other favorable properties,” said Chih-Hao Chang, associate professor in the Walker Department of Mechanical Engineering and leader of the new research. “But the same properties that make it attractive also make it difficult to manufacture at small scales.”