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Jul 24, 2023

What happens to the brain during consciousness-ending meditation?

Posted by in category: neuroscience

There’s a meditative state described in ancient Buddhist scriptures that is hard to imagine because it is not something – but nothing. Referred to as nirodha-samāpatti, it roughly translates as ‘the cessation of thought and feeling’, and it is the highest meditative state possible in Theravada Buddhism, following eight others called jhānas. Each jhāna requires deepening levels of concentration, and a retreat into the mind, away from typical consciousness.

According to David Vago, a psychologist at Vanderbilt University in Nashville and director of the Contemplative Neuroscience and Mind-Body Research Laboratory, nirodha-samāpatti refers to a ‘state of profound concentration or absorption in which all mental activity is temporarily suspended’. It’s said that the state leads to a total absence of sensation and awareness, which would help explain the stories of monks who stayed in this deep trance while fires burned around them.

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Jul 24, 2023

Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control

Posted by in category: neuroscience

Complex spikes (CSs) driven by inferior olivary neurons have crucial roles in motor control. Wang et al. identified an excitatory pathway from the cerebellar nuclei to the inferior olive that drives rapid feedback CSs and contributes to the fine control of ocular and body movements.

Jul 24, 2023

Probing the Abyss: Fermilab’s Dark SRF Experiment Illuminates the Search for Dark Photons

Posted by in categories: cosmology, particle physics

The Dark SRF experiment at the Fermi National Accelerator Laboratory has achieved unprecedented sensitivity in the search for hypothetical dark photons. By innovatively employing superconducting radio frequency (SRF) cavities, researchers can now explore different potential mass ranges for these elusive particles, pushing the boundaries of our understanding of dark matter.

Scientists working on the Dark SRF experiment at the U.S. Department of Energy’s Fermi National Accelerator Laboratory have demonstrated unprecedented sensitivity in an experimental setup used to search for theorized particles called dark photons.

Researchers trapped ordinary, massless photons in devices called superconducting radio frequency cavities to look for the transition of those photons into their hypothesized dark sector counterparts. The experiment has put the world’s best constraint on the dark photon.

Jul 24, 2023

Gene therapy eyedrops restored a boy’s sight. Similar treatments could help millions

Posted by in categories: biotech/medical, genetics

Dr. Alfonso Sabater pulled up two photos of Antonio Vento Carvajal’s eyes. One showed cloudy scars covering both eyeballs. The other, taken after months of gene therapy given through eyedrops, revealed no scarring on either eye.

Antonio, who’s been legally blind for much of his 14 years, can see again.

The teen was born with dystrophic epidermolysis bullosa, a that causes blisters all over his body and in his eyes. But his skin improved when he joined a clinical trial to test the world’s first topical gene therapy. That gave Sabater an idea: What if it could be adapted for Antonio’s eyes?

Jul 24, 2023

First Successful Transplant of Functional Cryopreserved Rat Kidney Performed

Posted by in category: biotech/medical

The first successful transplantation of a cryopreserved rat kidney has indicated that long-term storage of human organs for transplantation may be possible.

Jul 24, 2023

How Oppeheimer Visualizes “Almost Magical” Shift “From Classic Physics to Quantum Physics”

Posted by in categories: cosmology, military, quantum physics

Similar to Interstellar, Oppenheimer (now in theaters) finds Christopher Nolan at his most abstract, with the director working overtime to ascribe a visual language to concepts just beyond our comprehension.

It wasn’t enough to simply make a biopic about the father of the atomic bomb — he needed to take us inside the extraordinary theoretical mind of J. Robert Oppenheimer (played in the film by Cillian Murphy) and show us the Big Bang-like birth of quantum physics and how it directly led to the creation of the atomic bomb.

RELATED: Oppenheimer’s Atomic Bombs Marked a New Geologic Age of Humans.

Jul 24, 2023

‘Cocaine sharks’ off Florida may be feasting on dumped bales of drugs

Posted by in category: biotech/medical

“The other thing we might find is actually this long flow, [this] drip of pharmaceuticals: caffeine, lidocaine, cocaine, amphetamine, antidepressants, birth control — this long slow drift of them from cities into the [ocean] is… starting to hit these animals,” Hird said.


Shark Week show delves into whether sharks off the coast of Florida are coming into contact with the huge quantities of cocaine that get dumped in these waters.

Jul 24, 2023

Elon Musk plans to rebrand Twitter as ‘X’ — an idea that harkens back to the CEO’s early days when he was ousted from PayPal

Posted by in categories: Elon Musk, finance

Elon Musk announced plans on Saturday to ditch Twitter’s bird logo for an “X” — a reference to the CEO’s vision to create an all-encompassing “everything app” that may incorporate shopping and banking services, among other features.

The domain X.com now redirects users to Twitter. Musk said a new “interim” X logo will go live Sunday. He did not respond to a request for comment.

Jul 24, 2023

An Enormous Cosmological Simulation Wraps Up, Recreating Even More of the Universe

Posted by in categories: cosmology, evolution, particle physics

There’s an old joke among astronomy students about a question on the final exam for a cosmology class. It goes like this: “Describe the Universe and give three examples.” Well, a team of researchers in Germany, the U.S., and the UK took a giant leap toward giving at least one accurate example of the Universe.

To do it, they used a set of simulations called “MillenniumTNG”. It traces the buildup of galaxies and cosmic structure across time. It also provides new insight into the standard cosmological model of the Universe. It’s the latest in cosmological simulations, joining such ambitious efforts as the AbacusSummit project of a couple of years ago.

This simulation project takes into account as many aspects of cosmic evolution as possible. It uses simulations of regular (baryonic) matter (which is what we see in the Universe). It also includes dark matter, neutrinos, and the still-mysterious dark energy on the formation mechanisms of the Universe. That’s a tall order.

Jul 24, 2023

A synthetic biology platform enabling control over aging-associated stress response

Posted by in categories: bioengineering, biotech/medical, genetics, life extension, robotics/AI, virtual reality

Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety of pathological and aging-associated conditions.

A new publication, “Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape,” authored by company founders and featured on the cover of Cell Systems describes a technique that triggers the ISR virtually using light and demonstrates how the accumulation of stress over time shifts a cell’s reaction from adaptation to apoptosis (programmed cell death).

“In a very real way, our platform puts cells into a virtual reality, making them experience stress in the absence of physical stressors,” said Maxwell Wilson, Ph.D., a co-founder of Integrated Biosciences and Assistant Professor of Molecular, Cellular, and Developmental Biology at the University of California Santa Barbara.