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Is fungi our secret tool against antibiotic resistance?

face_with_colon_three fungi is even better than current medicines and frankly better for you. We can also ingest fungi that can help be a natural food medicine to help prevent worse diseases.

While all attention is on the pandemic right now, the SARS-CoV-2 virus isn’t the only microbial threat we face.

While we’re all rightly focused on the COVID-19 pandemic at the moment, the SARS-CoV-2 virus isn’t the only microbial threat we face.

Back in 2014, the World Health Organization (WHO) warned that within a decade, antibiotic-resistant bacteria could make routine surgery, organ transplantation and cancer treatment life-threateningly risky — and spell the end of modern medicine as we know it.

United Nations General Assembly’s AUDACITY 100 Disruptors Summit

face_with_colon_three Fungi can save all life on earth. This lecture teaches that mushrooms are outperforming even age old medicines.

Watch my 15 minute speech at the United Nations General Assembly’s AUDACITY 100 Disruptors Summit was a powerful reminder of how interconnected we all are.

I spoke about how fungal mycelium can help heal ecosystems, strengthen food systems, and strengthens the health.
of the residents of the planet. Mycelium supports our collective immunity.

When Mycelium Running: How Mushrooms Can Help Save the World was published in 2005, it foretold the mycelial revolution that continues to sweep the planet. This book is as relevant today as it was then. What has happened since? The scientific community continues to verify that mycelium is essential for our collective health, whether as nutritional supplements, or as the core fabric of our food webs.

How quantum computers can aid the search for room-temperature superconductors

For the first time, a quantum computer has successfully measured pairing correlations (quantum signals that show electrons teaming up in pairs), which is essential to helping scientists find one of the holy grails of physics—superconductors that work at room temperature.

Superconductors are materials that can conduct electricity with zero resistance, meaning no energy is lost as heat. To work, they need to be cooled to extremely low temperatures, which makes them expensive and impractical for widespread use. Physicists have been trying to tweak their structure to make them work at , and many believe that understanding and manipulating electron-pairing correlations are key to that breakthrough.

Peering inside 3D chaotic microcavities with X-ray vision

In the world of optics, tiny structures called microcavities—often no wider than a human hair—play a crucial role in technologies ranging from lasers to sensors.

These microscopic resonators trap light, allowing it to circulate millions of times within their boundaries. When they are perfectly shaped, light inside them moves in smooth, circular paths. But when their symmetry is slightly disturbed, the light begins to behave unpredictably, following chaotic routes that can lead to surprising effects like one-way laser emission or stronger light–matter interactions.

Until now, most research on this has focused on flat, two-dimensional microcavities. These are easier to study because their shape can be seen and measured under a microscope. But truly three-dimensional (3D) microcavities—where deformation occurs in all directions—have remained largely unexplored. Their internal geometry is difficult to capture without cutting or damaging the sample, making it hard to understand how light behaves inside them.

Scientists map DNA folding at single base-pair resolution in living cells

Scientists from Oxford’s Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control when and how genes are switched on.

Using a new technique called MCC ultra, the team mapped the down to a single base pair, unlocking how genes are controlled, or, how the body decides which genes to turn on or off at the right time, in the right cells. This breakthrough gives scientists a powerful new way to understand how lead to disease and opens up fresh routes for drug discovery.

“For the first time, we can see how the genome’s control switches are physically arranged inside cells, said Professor James Davies, lead author of the study published in the journal Cell titled ” Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.”

A long, bumpy caterpillar-like wormhole may connect two black holes

For obvious reasons, we do not know what the inside of a black hole looks like. But thanks to theoretical physics, we can ask what the inside should look like if Einstein’s theory of gravity and the rules of quantum mechanics are both true. A new study published in the journal Physical Review Letters has done exactly this by concentrating on two black holes that are deeply entangled (linked together by quantum rules).

The research by scientists from the U.S. and Argentina theoretically mapped the shared inner space between the two objects—the wormhole connecting them. They found that for a typical, messy entangled pair, the interior isn’t the smooth tunnel of science fiction.

Instead, it’s a long, lumpy structure they called the “Einstein-Rosen caterpillar.” It’s named after the Einstein-Rosen Bridge, the mathematical structure that connects two regions of spacetime, and “caterpillar” because of its bumpy, segmented shape. This discovery is a significant step toward proving that the bizarre rules of quantum mechanics can control the shape of spacetime inside a black hole.

AI-designed antibodies created from scratch

Research led by the University of Washington reports on an AI-guided method that designs epitope-specific antibodies and confirms atomically precise binding using high-resolution molecular imaging, then strengthens those designs so the antibodies latch on much more tightly.

Antibodies dominate modern therapeutics, with more than 160 products on the market and a projected value of US$445 billion in 5 years. Antibodies protect the body by locking onto a precise spot—an epitope—on a virus or toxin.

That pinpoint connection determines whether an antibody blocks infection, marks a pathogen for removal, or neutralizes a harmful protein. When a drug antibody misses its intended epitope, treatment can lose power or trigger side effects by binding the wrong target.

Textbook view of NMDA receptor calcium signals upended by new findings

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were developed based on the assumption that the proportion of calcium in the current produced by these receptors remains constant. That assumption turns out to be false, according to University at Buffalo research published last month in the Proceedings of the National Academy of Sciences.

“Our research reveals that small variations in the brain environment in which NMDA receptors operate can increase or decrease the amount of in the currents fluxed by these receptors,” explains Gabriela K. Popescu, Ph.D., corresponding author and professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB. “This, in turn, could mean the difference between normal and impaired learning, memory and cognition, symptoms that accompany many neuropsychiatric conditions.”

Gyromorphs combine liquid and crystal traits to enhance light-based computers

Researchers have been developing computers that deploy light (photons) rather than electricity to power storage and calculations. These light-based computers have the potential to be more energy efficient than traditional computers while also running calculations at greater speeds.

However, a major challenge in the production of light-based computers—still in their infancy—is successfully rerouting microscopic light signals on a computer chip with minimal loss in . This is fundamentally a materials-design problem. These computers require a to block additional light from all incoming directions—what’s known as an “isotropic bandgap material”—in order to maintain signal strength.

Scientists at New York University report the discovery of gyromorphs—a material that combines the seemingly incompatible properties of liquids and crystals and that performs better than any other known structure in blocking light from all incoming angles.

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