Scientists reveal how the Dsup protein found in tardigrades protects DNA from extreme radiation, which is key for future space missions.
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Exercise and the Organ-Brain Axis: Regulation of Neurological Disorders by Emerging Exerkines
Research on exercise and brain disorders has traditionally focused on its direct regulatory effects on neurons and synapses, neglecting peripheral organ-mediated pathways. To address this gap, this review proposes the novel concept of the “multi-organ-brain axis.” This concept posits that during brain disorders, functional alterations in peripheral organs such as skeletal muscle, heart, liver, adipose tissue, and spleen can disrupt metabolic and immune homeostasis, thereby bidirectionally modulating brain function via signaling molecules and metabolites.
The first 25 years of SuperAger research show cognitive decline is not an inevitable part of aging
For 25 years, scientists at Northwestern Medicine have been studying individuals aged 80 and older—dubbed “SuperAgers”—to better understand what makes them tick.
These unique individuals, who show outstanding memory performance at a level consistent with individuals who are at least three decades younger, challenge the long-held belief that cognitive decline is an inevitable part of aging.
Over the quarter-century of research, the scientists have seen some notable lifestyle and personality differences between SuperAgers and those aging typically—such as being social and gregarious—but “it’s really what we’ve found in their brains that’s been so earth-shattering for us,” said Dr. Sandra Weintraub, a professor of psychiatry and behavioral sciences and neurology at Northwestern University Feinberg School of Medicine.
