Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.
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From Algebra to Cosmology: Stephen Wolfram on Physics & the Nature of the Universe
Physicist and computer scientist Stephen Wolfram explores how simple rules can generate complex realities, offering a bold new vision of fundamental physics and the structure of the universe.
Stephen Wolfram is a British-American computer scientist, physicist, and businessman. He is known for his work in computer algebra and theoretical physics. In 2012, he was named a fellow of the American Mathematical Society. He is the founder and CEO of the software company Wolfram Research, where he works as chief designer of Mathematica and the Wolfram Alpha answer engine.
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Cryonics & Cryptography | Ralph Merkle at Vitalist Bay
Veteran cryonicist and inventor of cryptographic hashing, Ralph Merkle, tells us how he came to decide that cryonics was a good idea. In his talk, Ralph discusses Information Theoretic Death, why information is so hard to destroy, and how advances in nano-tech might make cryonics revival possible.
Links:
• Cryosphere Discord server: https://discord.com/invite/ndshSfQwqz.
• Cryonics subreddit: https://www.reddit.com/r/cryonics/
#cryosphere
Nanoparticles show potential for rheumatoid arthritis prevention and flare control
As a chronic condition, rheumatoid arthritis (RA) can’t be cured, so treatment focuses on managing the disease and controlling its progression. Although current treatments help control RA symptoms in most people, they cannot prevent the onset of RA or painful flare-ups.
Now, researchers publishing in ACS Central Science have developed nanoparticles that could slow disease progression and reduce flare severity, based on results from tests with human blood and mice models with RA-like disease.
For a person diagnosed with RA, their immune system attacks tissue that makes up the joints, causing inflammation, swelling and pain. However, as the disease progresses, serious cartilage and bone damage can occur if left uncontrolled.
Computational tool ranks compounds to improve cancer immunotherapy effectiveness
A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies.
Immunotherapy, particularly immune checkpoint blockade (ICB), has revolutionized cancer treatment. Widespread resistance to ICB is a major challenge in clinical practice.
To enhance treatment efficacy and overcome resistance, combining ICB therapy with chemotherapy or targeted therapy has become an important research direction. However, candidate combinations rely on empirical selection from existing drugs, and it is difficult to discover new candidates.
How AI, robots and other cutting-edge technologies can keep workers safe and sound
Can artificial intelligence, robots and surveillance protect workers on the job? Yes, according to the latest report from the International Labour Organization. In this episode of the Future of Work podcast, ILO occupational safety and health expert Manal Azzi explains how AI and technology is being used as a safety net, and not a threat, for workers worldwide.
Ghost particles may secretly decide the fate of collapsing stars
Neutrinos are cosmic tricksters, paradoxically hardly there but lethal to stars significantly more massive than the sun. These elementary particles come in three known “flavors”: electron, muon and tau. Whatever the flavor, neutrinos are notoriously slippery, and much about their properties remains mysterious. It is almost impossible to collide neutrinos with each other in the lab, so it is not known if neutrinos interact with each other according to the standard model of particle physics, or if there are much-speculated “secret” interactions only among neutrinos.
Now a team of researchers from the Network for Neutrinos, Nuclear Astrophysics, and Symmetries (N3AS), including several from UC San Diego, have shown, through theoretical calculations, how collapsing massive stars can act as a “neutrino collider.” Neutrinos steal thermal energy from these stars, forcing them to contract and causing their electrons to move near light speed. This drives the stars to instability and collapse.
Eventually the collapsing star’s density becomes so high that the neutrinos are trapped and collide with each other. With purely standard model interactions, the neutrinos will be mostly electron flavor, the matter will be relatively “cold,” and the collapse will likely leave a neutron star remnant. However, secret interactions that change neutrino flavor radically alter this scenario, producing neutrinos of all flavors and leading to a mostly neutron “hot” core that may lead to a black hole remnant.