Antimicrobial resistance (AMR) presents a serious challenge in today’s world. The use of antimicrobials (AMU) significantly contributes to the emergence and spread of resistant bacteria. Companion animals gain recognition as potential reservoirs and vectors for transmitting resistant microorganisms to both humans and other animals. The full extent of this transmission remains unclear, which is particularly concerning given the substantial and growing number of households with companion animals. This situation highlights critical knowledge gaps in our understanding of risk factors and transmission pathways for AMR transfer between companion animals and humans. Moreover, there’s a significant lack of information regarding AMU in everyday veterinary practices for companion animals.
Antimicrobial resistance (AMR) presents a serious challenge in today’s world. The use of antimicrobials (AMU) significantly contributes to the emergence and spread of resistant bacteria. Companion animals gain recognition as potential reservoirs and vectors for transmitting resistant microorganisms to both humans and other animals. The full extent of this transmission remains unclear, which is particularly concerning given the substantial and growing number of households with companion animals. This situation highlights critical knowledge gaps in our understanding of risk factors and transmission pathways for AMR transfer between companion animals and humans. Moreover, there’s a significant lack of information regarding AMU in everyday veterinary practices for companion animals. The exploration and development of alternative therapeutic approaches to antimicrobial treatments of companion animals also represents a research priority. To address these pressing issues, this Reprint aims to compile and disseminate crucial additional knowledge. It serves as a platform for relevant research studies and reviews, shedding light on the complex interplay between AMU, AMR, and the role of companion animals in this global health challenge. This Reprint is especially addressed to companion animal veterinary practitioners as well as all researchers working on the field of AMR in both animals and humans, from a One Health perspective.
Neutrophils, one of the immune system warriors that were thought to be all the same, turn out to be diverse. Unfortunately, these cells are also active in autoimmune diseases. New research has found that a certain subpopulation of these white blood cells can predict disease relapse at an early stage, which may enable improved personalized treatment.
In a study published in Nature Communications, a multi-institutional research team investigated which cell types dominate the blood of patients at the early stage of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, which is caused by inflammation in the blood vessels and can disrupt organ function.
“Figuring out the mechanism of this disease, which is poorly understood, will help us understand autoimmune dysregulation in neutrophils. This could aid in the development of new drugs tailored for each patient,” says the lead author of the study. “Because we want to understand the dynamics of neutrophil behavior at the cell level in the early stages of the disease, for this study we recruited new patients that had not yet been treated.”
Scientists found a compound that appears to counter common mutations behind POLG-related diseases, rare conditions that harm mitochondrial DNA.
Is the nearest galaxy to ours being torn apart? Research suggests so. A team led by Satoya Nakano and Kengo Tachihara at Nagoya University in Japan has revealed new insights into the motion of massive stars in the Small Magellanic Cloud (SMC), a small galaxy neighboring the Milky Way. Their findings suggest that the gravitational pull of the Large Magellanic Cloud (LMC), the SMC’s larger companion, may be tearing the smaller one apart. This discovery reveals a new pattern in the motion of these stars that could transform our understanding of galaxy evolution and interactions. The results were published in The Astrophysical Journal Supplement Series.
“When we first got this result, we suspected that there might be an error in our method of analysis,” Tachihara said. “However, upon closer examination, the results are indisputable, and we were surprised.”
The SMC remains one of the closest galaxies to the Milky Way. This proximity allowed the research team to identify and track approximately 7,000 massive stars within the galaxy. These stars, which are over eight times the mass of our Sun, typically survive for only a few million years before exploding as supernovae. Their presence indicates regions rich in hydrogen gas, a crucial component of star formation.
The pointy edges of petals rely on a type of geometric feedback never before seen in nature.
In the shadow of the wrecked nuclear power plant in Fukushima, Japan, a new research centre is seeking to revitalize the region.
Urea, with the formula CO(NH2)2, is a chemical compound that is widely used in a range of sectors, including manufacturing, agriculture and various industries. Conventionally, this compound is produced via a two-step process that entails the synthesis of ammonia from nitrogen (N₂) and its subsequent reaction with carbon dioxide (CO₂).
This reaction occurs at high temperatures and under high pressure, leading to the formation of a compound called ammonium carbamate. This compound is then decomposed at lower pressures, which ultimately produces urea and water.
Traditional processes for producing urea are very energy intensive, meaning that to produce desired amounts of urea they consume a lot of electrical power. Over the past few years, some engineers have thus been trying to devise more energy-efficient strategies to synthesize urea.
IN A NUTSHELL 🌍 The Three Gorges Dam in China is the largest hydroelectric dam globally, symbolizing China’s engineering prowess. 🔍 NASA suggests that the dam’s massive water displacement might influence Earth’s rotation, affecting the planet’s natural balance. 💧 The dam’s reservoir, when full, could lengthen the day by 0.06 microseconds and alter Earth’s shape.
What if there were a fabric that, like Superman, could take a bullet and self-heal? Such a super-dynamic, action-powered polymer might actually help protect real-life flyers in space.
Material scientists at Texas A&M University have developed just such a polymer with a unique self-healing property never before seen at any scale. When struck by a projectile, this material stretches so much that when the projectile manages to pass through, it takes only a small amount of the polymer with it. As a result, the hole left behind is much smaller than the projectile itself.
However, for now, this effect has only been observed under extreme temperatures and at the nanoscale.