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New study suggests a way to rejuvenate the immune system

As people age, their immune systems decline. But a new study suggests a way to rejuvenate immune function: Stimulating the liver to produce some signals ordinarily generated by the thymus can reverse age-related declines in T-cell populations.

MIT and Broad Institute researchers found a way to overcome age-related immune system decline by temporarily programming liver cells to take over the maturation of T cells. Using mRNA, the researchers were able to rejuvenate the immune system, in a study of mice.

Snakes’ mind-bending ‘heat vision’ inspires scientists to build a 4K imaging system that could one day fit into your smartphone

Scientists in China have developed a first-of-its-kind artificial imaging system inspired by snakes that are able to “see” heat coming off their prey in total darkness. The sensor captures ultra-high-resolution infrared (IR) images in 4K resolution (3,840 × 2,160 pixels) — matching the image quality of the iPhone 17 Pro’s camera.

Any object with a temperature above absolute zero (−460 degrees Fahrenheit or-273 degrees Celsius) emits some electromagnetic radiation. For normal body heat, this has a wavelength in the IR range. The human eye can only pick up shorter wavelengths that are in the visible light range.

Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

Xiaojia Li et al. demonstrated that Plakophilin 3 is transformed from a structural protein into an oncogenic molecule, driving acinar cell transformation and promoting cancer initiation and progression in the pancreas through FOXM1 protein stabilization.

Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits.

Question Did outcomes following intravenous tenecteplase for minor ischemic stroke vary based on the presence of disabling deficits?

Findings In this secondary analysis of the TEMPO-2 randomized clinical trial including 884 patients with minor ischemic stroke and proven intracranial occlusion, both patients with and without disabling deficits defined according to US National Institutes of Health Stroke Scale (NIHSS)–based criteria showed a neutral treatment effect from intravenous tenecteplase, with no significant effect modification.

Meaning Current definitions of disabling stroke did not modify the neutral treatment effect of intravenous tenecteplase in patients with minor stroke and intracranial occlusion.

Clinical Obesity and All-Cause and Cause-Specific Mortality in UK Biobank

Clinical obesity, as newly defined by excess adiposity and organ dysfunction, was linked to greater all-cause and cause-specific mortality risk in the UK Biobank cohort.

This study evaluates the association between a new definition of obesity with mortality data in the UK Biobank.

Comparison of Diagnostic Parameters Using Cardiac CT–derived Aortic Valve Area and Aortic Valve Calcium Scores for Low-Gradient Aortic Stenosis

Comparing performance of cardiac CT–derived hybrid aortic valve area and planimetry, in combination with aortic valve calciumor AVC density, for assessing low-gradient aortic stenosis.

To compare the performance of cardiac CT–derived hybrid aortic valve area (AVA) and planimetry, in combination with aortic valve calcium (AVC) or AVC density (AVCd), for assessing low-gradient aortic stenosis (LGAS).

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