Lifeboat Foundation

As astronauts venture further into space, their exposure to harmful radiation rises. Researchers from Columbia University are simulating the effects of space radiation here on Earth to determine its impact on human physiology using multi-organ tissue chips. Their work documents the differential effects seen in tissues after acute and prolonged radiation exposure and identifies multiple genes of interest that could help inform the development of future radioprotective agents.

Their study appears in Advanced Science.

“As deep space exploration continues to unfold, it is vital to understand the physiological damage caused by space radiation to better mitigate its effects. By exposing multi-organ models to simulated cosmic radiation, this study has laid the groundwork to aid in this effort,” commented Jermont Chen, Ph.D., a program director in the Division of Discovery Science and Technology at NIBIB.

For nearly his entire life, Dr. Stuart Hameroff has been fascinated with the bedeviling question of consciousness. But instead of studying neurology or another field commonly associated with the inner workings of the brain, it was Hameroff’s familiarity with anesthetics, a family of drugs that famously induces the opposite of consciousness, that fueled his curiosity.

“I thought about neurology, psychology, and neurosurgery, but none of those… eemed to be dealing with the problem of consciousness,” says Hameroff, a now-retired professor of anesthesiology from the University of Arizona. Hameroff recalls a particularly eye-opening moment when he first arrived at the university and met the chairman of the anesthesia department. “He says ‘hey, if you want to understand consciousness, figure out how anesthesia works because we don’t have a clue.’”

Hameroff’s work in anesthesia showed that unconsciousness occurred due to some effect on microtubules and wondered if perhaps these structures somehow played a role in forming consciousness. So instead of using the neuron, or the brain’s nerve cells, as the “base unit” of consciousness, Hameroff’s ideas delved deeper and looked at the billions of individual tubulins inside microtubules themselves. He quickly became obsessed.

This bioengineering breakthrough has found a way to make neurons grown in a dish react just like the real thing.

Enter Stephen wolfram afterwords.

Chief product officer of ‘responsible AI’ says the focus needs to be on augmenting — not replicating — human capabilities.

The outgoing head of the US Department of Homeland Security believes Europe’s “adversarial” relationship with tech companies is hampering a global approach to regulating artificial intelligence that could result in security vulnerabilities.

Alejandro Mayorkas told the Financial Times the US — home of the world’s top artificial intelligence groups, including OpenAI and Google — and Europe are not on a “strong footing” because of a difference in regulatory approach.

He stressed the need for “harmonisation across the Atlantic”, expressing concern that relationships between governments and the tech industry are “more adversarial” in Europe than in the US.

Researchers at University of California San Diego have developed and tested a new software package, called Spatial Modeling Algorithms for Reactions and Transport (SMART), that can realistically simulate cell-signaling networks—the complex systems of molecular interactions that allow cells to respond to diverse cues from their environment.

Cell-signaling networks involve many distinct steps and are also greatly influenced by the complex, three-dimensional shapes of cells and subcellular components, making them difficult to simulate with existing tools. SMART offers a solution to this problem, which could help accelerate research in fields across the life sciences, such as systems biology, pharmacology and biomedical engineering.

The researchers successfully tested the new software in biological systems at several different scales, from cell signaling in response to adhesive cues, to calcium release events in subcellular regions of neurons and cardiac muscle cells, to the production of ATP (the energy currency in cells) within a detailed representation of a single mitochondrion.

Amazon announced a major milestone in its electric vehicle transition, officially bringing 20,000 Rivian EDVs (electric delivery vans) into its fleet.

Back in 2019, Amazon announced its Climate Pledge to achieve net-zero carbon emissions by 2040. Part of the Pledge included a partnership with Rivian for 100,000 all-electric delivery vehicles. The goal was to have all EDVs on the road and in the Amazon fleet by 2030.

The first Amazon-Rivian EDV hit the road in 2022, and since then, the vans have made it to thousands of locations across the United States.