The data shows that RNA interacts with a mitochondrial protein complex to trigger immune response pathways when viral RNA is present.
Penn Engineers have modified lipid nanoparticles (LNPs)—the revolutionary technology behind the COVID-19 mRNA vaccines—to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.
In a new paper in Nano Letters, the researchers demonstrate how peptides —short strings of amino acids —can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.
This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.
There is more research than ever focused on reflecting sunlight away from the planet to cool the climate – but there are still far more questions than answers about the effects.
To create cultured LMNs that replicate ALS neuron physiology and function, the Japanese team combined a small molecule-based approach with transcription factor transduction. The researchers achieved 80% induction efficiency of LMNs within just two weeks compared with conventional methods.
The resulting LMNs were found to have replicated ALS-specific pathologies, such as the abnormal aggregation of TDP-43 and FUS proteins. The team confirmed functionality of the LMNs using a multi-electrode array (MEA) system to measure firing activity and network activity, which were found to be similar to mature neurons.
Further analysis of the cultured LMNs showed that in addition to maintaining ALS cellular markers, the LMNs had reduced survival rates compared with healthy cells, mimicking ALS motor neuron responses.
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The sublime is an emotion described as equal parts awe and terror; a perfect description of our universe.
Up to now, the search for extraterrestrial life has focused on finding a planet like our own. But could alien biology create its own habitable havens?
If all the world’s a stage and all the species merely players, then their exits and entrances can be found in the rock record. Fossilized skeletons and shells clearly show how evolution and extinction unfolded over the past half a billion years, but a Virginia Tech analysis extends the chart of life to nearly 2 billion years ago. The study is published in the journal Science.
The chart shows the relative ups and downs in species counts, telling scientists about the origin, diversification, and extinction of ancient life.
With this new study, the chart of life now includes life forms from the Proterozoic Eon, 2,500 million to 539 million years ago. Proterozoic life was generally smaller and squishier—like sea sponges that didn’t develop mineral skeletons —and left fewer traces to fossilize in the first place.
In their Review article earlier this year, Fedorenko, Ivanova & Regev (Fedorenko, E., Ivanova, A. A. & Regev, T. I. The language network as a natural kind within the broader landscape of the human brain. Nat. Rev. Neurosci. 25, 289–312 (2024))1 propose a functional separation between the core language network and other perceptual, motor and higher-level cognitive components of communication-related networks in the left hemisphere of the human brain. In the ‘Open questions and a way forward’1 section that ends their Review, the authors discuss the need for cross-species comparative research to disentangle how these brain networks came to support human language. Here, we suggest that the authors’ functional separation of a core language network and other components in the human brain is grounded in the evolution of two separate structural networks within primate brains.
Fedorenko and colleagues describe the core language network as left-lateralized, and involving the middle frontal gyrus (MFG), inferior frontal gyrus (IFG), superior temporal gyrus (STG) and middle temporal gyrus (MTG). Perceptual and motor systems for speech are defined as separate subsystems located in auditory cortex and speech perception areas in the STG and motor cortex and motor planning areas1, respectively. Importantly, these functionally defined key brain areas are known to be structurally connected via dorsally and ventrally located white-matter fibre tracts, which guarantee the information flow between areas. In humans, two separate dorsal pathways that provide structural connections have been identified for two distinct networks2,3 (Fig. 1).
ABSTRACT. We present a new, cosmologically model-independent, statistical analysis of the Pantheon$+$ Type Ia Supernovae spectroscopic data set, improving.
Investigators from Cedars-Sinai and the University of California, San Francisco (UCSF) have identified a new way to deliver instructions that tell stem cells to grow into specific bodily structures, a critical step in eventually regenerating and repairing tissues and organs.
The scientists engineered cells that form structures called “synthetic organizers.” These organizers provided instructions to the stem cells through biochemical signals called morphogens, which stimulated and enabled the stem cells to grow into specific complex tissues and organ-like assemblies.
The research was conducted with mouse embryonic stem cells, and the findings were published in Cell.
