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TAU Breakthrough Offers New Hope to Help People With Paralysis Walk Again
Paralysis from spinal injury has long remained untreatable. Could scientific developments get people affected on their feet again sooner than imagined? In a worldwide first, Tel Aviv University researchers have engineered 3D human spinal cord tissues and implanted them in a lab model with long-term chronic paralysis, demonstrating high rates of success in restoring walking abilities. Now, the researchers are preparing for the next stage of the study, clinical trials in human patients.
Shape-changing soft material for soft robotics, smart textiles and more
Harvard researchers developed liquid crystal elastomers that can switch between multiple shapes — chevrons, flat layers, and coils — in response to heat.
By aligning molecules in different directions, the material can be programmed to morph into domes, saddles, or fin-like motions inspired by stingrays and jellyfish.
The shape-shifting material could advance applications in soft robotics, biomedical devices, and smart textiles.
Liquid crystal elastomers are a class of soft materials that can change shape in response to stimuli such as light or heat — making them promising for applications in soft robotics, wearable and biomedical devices, smart textiles and more. But designing compositionally uniform elastomers that can change into different shapes in response to just one stimulus has been challenging and has limited the application of these potentially powerful materials.
Now, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a way to program liquid crystal elastomers with the ability to deform in opposite directions just by heating — opening up a range of applications.
The research was published in Science.
(May be a repost from 2024)
A Wearable Robot That Learns
Having lived with an ALS diagnosis since 2018, Kate Nycz can tell you firsthand what it’s like to slowly lose motor function for basic tasks. “My arm can get to maybe 90 degrees, but then it fatigues and falls,” the 39-year-old said. “To eat or do a repetitive motion with my right hand, which was my dominant hand, is difficult. I’ve mainly become left-handed.”
People like Nycz who live with a neurodegenerative disease like ALS or who have had a stroke often suffer from impaired movement of the shoulder, arm or hands, preventing them from daily tasks like tooth-brushing, hair-combing or eating.
For the last several years, Harvard bioengineers have been developing a soft, wearable robot that not only provides movement assistance for such individuals but could even augment therapies to help them regain mobility.
But no two people move exactly the same way. Physical motions are highly individualized, especially for the mobility-impaired, making it difficult to design a device that works for many different people.
It turns out advances in machine learning can create a more personal touch. Researchers in the John A. Paulson School of Engineering and Applied Sciences (SEAS), together with physician-scientists at Massachusetts General Hospital and Harvard Medical School, have upgraded their wearable robot to be responsive to an individual user’s exact movements, endowing the device with more personalized assistance that could give users better, more controlled support for daily tasks.
Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases
With the intensification of global aging, the incidence of age-related diseases (including cardiovascular, neurodegenerative, and musculoskeletal disorders) has been on the rise, and cellular senescence is identified as the core driving mechanism. Cellular senescence is characterized by irreversible cell cycle arrest, which is caused by telomere shortening, imbalance in DNA damage repair, and mitochondrial dysfunction, accompanied by the activation of the senescence-associated secretory phenotype (SASP). In this situation, proinflammatory factors and matrix-degrading enzymes can be released, thereby disrupting tissue homeostasis. This disruption of tissue homeostasis induced by cellular senescence manifests as characteristic pathogenic mechanisms in distinct disease contexts. In cardiovascular diseases, senescence of cardiomyocytes and endothelial cells can exacerbate cardiac remodeling.
Stem cell-derived dopamine neurons improve depression-like behaviors in mice
The Institute of Neuroscience, Chinese Academy of Sciences, reports that human stem cell-derived A10-like midbrain dopaminergic neurons integrate into mouse mesocorticolimbic circuits and suppress anxiety and depression behaviors upon activation.
Midbrain dopaminergic neurons regulate voluntary movement, reward, motivation, cognition, and emotions. A10 ventral tegmental area neurons connect with nucleus accumbens, amygdala, olfactory tubercle, and medial prefrontal cortex. Dysfunction of the A10 system is implicated in drug addiction, schizophrenia, and depression.
Human pluripotent stem cells enable fresh production of disorder-relevant neurons, with previous success in enriching A9 neurons for Parkinson’s disease therapy. Efficient differentiation of human A10 dopaminergic neurons remains elusive.
