MIT chemists have developed a new way to synthesize complex molecules that were originally isolated from plants and could hold potential as antibiotics, analgesics, or cancer drugs.
In this interview, hosted by Nicolás Cherñavsky, Nir Barzilai and Brad Stanfield discuss metformin, whether or not to use it in non-diabetic patients to slow aging, and the TAME trial.
Nir Barzilai is president of the Academy of Health and Lifespan Research (https://www.ahlresearch.org/), and Brad Stanfield is a primary care physician in Auckland (New Zealand) and runs a YouTube channel (/ @drbradstanfield) with around 250,000 subscribers to explore the latest research and preventive care guidelines.
Host: Nicolás Cherñavsky.
Production: Nicolás Cherñavsky and Nina Torres Zanvettor.
Editing: Nina Torres Zanvettor.
Revision and subtitling: Nicolás Cherñavsky.
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Notes:
TAME trial website: https://www.afar.org/tame-trial.
Diabetes Prevention Program Outcomes Study (DPPOS): https://repository.niddk.nih.gov/stud…
UK metformin vs sulfonylurea trial on type 2 diabetics: https://www.cmajopen.ca/content/2/3/E162
The New England Journal of Medicine paper on metformin treatment in Covid-19 patients: https://www.nejm.org/doi/full/10.1056…
Lancet paper on metformin treatment in Covid-19 patients: https://www.thelancet.com/journals/la…
Andre Scott’s paper on the cost-effectiveness of treating aging: https://www.nature.com/articles/s4358…
Medical guidelines database mentioned by Brad Stanfield: https://uptodate.com.
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Heales website (Healthy Life Extension Society): https://heales.org/
Contact e-mail: [email protected].
With the detection of a long-predicted “neutrino fog,” the search for particles of dark matter has entered a new age of both possibility and peril.
The decades-long search for dark matter could ultimately end in an impasse.
Scientists are experimenting with enzymes that turn sugar to fiber in the gut, microscopic sponges to soak up sugar, and more.
“Establishing that there is a big reservoir of liquid water provides some window into what the climate was like or could be like,” said Dr. Michael Manga.
While Mars is incapable of having liquid water on its surface, what about underground, and how much could there be? This is what a recent study published in the Proceedings of the National Academy of Sciences hopes to address as a team of researchers investigated how liquid water might be present beneath the Martian surface. This study holds the potential to help researchers not only better understand the current conditions on the Red Planet, but also if these same conditions could have led to life existing on the surface in the past.
For the study, the researchers analyzed seismic data obtained by NASA’s now-retired InSight lander, which landed on Mars in 2018 and sent back valuable data regarding the interior of Mars until the mission ended in 2022. This was after mission planners determined the amount of dust that had collected on the lander’s solar panels did not allow for sufficient solar energy to keep it functioning. However, despite being expired for two years, scientists continued to pour over vast amounts of data regarding the interior of Mars.
Now, after combining this seismic data with models used on Earth to map underground oil fields and aquifers, the researchers determined that igneous rocks (cooled magma) are drenched in liquid water between 11.5 and 20 kilometers (7.15 and 12.4 miles) beneath the Martian surface. Additionally, they ascertained the volume of this liquid water could cover the entire surface of Mars up to approximately one-mile deep. The presence of liquid water beneath the surface could help scientists better understand the water cycle on Mars, but accessing this water for future astronauts or colonists is out of the question given its depth.
Inventing a new, faster way to produce sustainable, self-dyed leather alternatives is a major achievement for synthetic biology and sustainable fashion. Professor Tom Ellis
Synthetic chemical dyeing is one of the most environmentally toxic processes in fashion, and black dyes – especially those used in colouring leather – are particularly harmful. The researchers at Imperial set out to use biology to solve this.
Atomic-scale 2D magnets can be polarized to represent binary states — the 1s and 0s of computing data. These can lead to far more dense and energy-efficient components.
Get a Wonderful Person Tee: https://teespring.com/stores/whatdamathMore cool designs are on Amazon: https://amzn.to/3QFIrFXAlternatively, PayPal donations ca…
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