The brain is busy even when you’re just zoning out.
When your mind is wandering, your brain’s “default mode” network is active. Its discovery 20 years ago inspired a raft of research into networks of brain regions and how they interact with each other.
Staphylococcus aureus bacteremia have their antibiotic treatment switched early from IV to oral?
Switching to oral antibiotic therapy can be as effective as prolonged intravenous (IV) therapy for several infections, including bone and joint infections and endocarditis (NEJM JW Infect Dis Jan 30 2019 and N Engl J Med 2019; 380:425; NEJM JW Gen Med Apr 14 2020 and JAMA Intern Med 2020; 180:769). European investigators now report results of an open-label, controlled noninferiority trial comparing a switch to oral antibiotics or continued IV treatment after 5 to 7 days of IV therapy in individuals with low-risk Staphylococcus aureus bacteremia (e.g., clearance of bacteremia within 72 hours, no evidence of deep-seated focus). Total duration of therapy was 14 days; oral options were trimethoprim-sulfamethoxazole, clindamycin, or linezolid; IV options were flucloxacillin, cefazolin, vancomycin, or daptomycin).
The trial was terminated after 213 of 5,063 screened individuals had been enrolled over a 6-year period. Oral therapy was found to be noninferior to IV therapy (in both intention-to-treat and clinically evaluable analyses) for the primary composite outcome of complications from S. aureus infection within 90 days. Two deaths due to S. aureus bacteremia occurred (both in the oral switch group), and 34% of the oral switch group versus 26% of the IV group had a serious adverse event (P=0.29) that was most commonly infectious.
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Study reveals shared brain proteomic signatures in Alzheimer’s disease and epilepsy, suggesting common molecular mechanisms that could pave the way for unified therapeutic strategies.
The creation of an artificial intelligence (AI) system that can analyze retinal fundus images to detect chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) represents a groundbreaking advancement in medical technology. This AI model, developed using a substantial dataset of retinal images and advanced convolutional neural networks, has demonstrated exceptional accuracy in identifying these conditions. Its capability extends beyond mere detection, as it also shows promise in predicting the progression of these diseases based on retinal imaging and clinical metadata.
A notable innovation of this AI system is its ability to analyze smartphone images. This feature significantly enhances the accessibility of sophisticated diagnostic tools, especially in regions with limited healthcare resources. The AI model paves the way for more widespread and convenient health screenings by enabling ubiquitous smartphone technology for medical imaging. This development is particularly impactful in enhancing healthcare delivery and access, as it brings critical diagnostic capabilities into the hands of more people, even in remote or underserved areas.
The AI’s proficiency in predicting the future development of CKD and T2DM is another aspect of its novelty. This predictive ability is crucial for timely intervention, potentially altering the trajectory of these chronic illnesses. Early detection and management are vital in battling CKD and T2DM, and this AI model’s predictive power could significantly improve patient outcomes.
Micro Electro Mechanical Systems (MEMS) are miniature devices that integrate mechanical elements, sensors, actuators, and electronics on a single silicon chip. These systems serve diverse applications, such as accelerometers in smartphones, gyroscopes in navigation systems, and pressure sensors in medical devices. MEMS devices can detect and respond to environmental changes, enabling the creation of smart, responsive technologies. Their small size, low power consumption, and ability to perform various functions make MEMS crucial in fields like telecommunications, healthcare, automotive, and consumer electronics. Learn more about this tiny machines with this video!
#science #technology #microscopic #nanotechnology #robotics #engineering
QuEra is cofident that by 2026 it would have built a commercial quantum computer that can beat supercomputers of today with ease.
Californian students from the Art Center College had to imagine four concepts of cars of the future for Lincoln, by 2040. One of them, a four-seater sedan, was entitled to the realization of its 1:1 scale model, presented during Monterey Car Week, completed this weekend. Connected, autonomous, shared (“shared”), and electric, as suggested by the acronym “CASE” used by Ford’s luxury brand, which is found in this sedan called “Anniversary”
