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Summary: Postmortem brains of those with schizophrenia have fewer genes associated with 12-hour activity cycles in the dorsolateral prefrontal cortex. Mitochondrial-related genes in the dlPFC did maintain a 12-hour rhythm, but their activity did not peak at normal times.

Source: PLOS

Researchers at the University of Pittsburgh School of Medicine, U.S. present the first evidence of 12-hour cycles of gene activity in the human brain.

Summary: When actors hear their own names during a performance, their response is suppressed by activity in the left anterior prefrontal cortex, a brain area associated with self-awareness.

Source: UCL

Actors may suppress their core sense of self when acting, as they immerse themselves in a new role, finds a new study by UCL researchers.

Summary: Rhythmic bursts of activity in the prefrontal cortex reduce variability as an animal focuses on a task.

Source: picower institute for learning and memory.

Working memory, that handy ability to consciously hold and manipulate new information in mind, takes work. In particular, participating neurons in the prefrontal cortex have to work together in synchrony to focus our thoughts, whether we’re remembering a set of directions or tonight’s menu specials.

Summary: Extended intense cognitive work causes potentially toxic byproducts to build up in the prefrontal cortex. This alters control over decision-making, causing a shift toward low-cost actions that require less effort as cognitive fatigue sets in.

Source: Cell Press.

It’s no surprise that hard physical labor wears you out, but what about hard mental labor? Sitting around thinking hard for hours makes one feel worn out, too.

Summary: AgRP neurons in the hypothalamus play a critical role in shaping the structure and function of the prefrontal cortex in mice. The findings shed light on how the prefrontal cortex is altered in disorders such as schizophrenia.

Source: Yale.

The prefrontal cortex region of the human brain is responsible for a range of complex functions from decision-making to certain types of memory.

Hubert, K.F., Awa, K.N. & Zabelina, D.L. Sci Rep 14, 3,440 (2024). https://doi.org/10.1038/s41598-024-53303-w.

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The quartet will fly aboard SpaceX’s Dragon Endeavour capsule, which previously flew Demo Mission-2, Crew-2, Crew-6 and Axiom Mission 1.

SpaceX recently tested Starlink’s Direct to Cell satellites and posted on Elon Musk’s X platform.

The test X post simply said: “This post was sent through a SpaceX Direct to Cell satellite.”

SpaceX’s Director of Satellite Engineering provided more information about the X post. He revealed that the post was made under the cover of trees in a small valley in the Santa Cruz Mountains.

Although the interplay between sex and mental health is well-studied, a new study suggests there may be a complex correlation between seemingly disparate disorders.

In a new paper published in the Journal of Affective Disorders Reports, a group of Italian psychology researchers say they’ve found a correlation between attention-deficit/hyperactivity disorder (ADHD), depressive symptoms, hypomania (the clinical term for “mania” or high energy) and hypersexuality, or an intense preoccupation with sexual thoughts and acts — and that people who experience these sets of symptoms may use sex as a sort of “self-medication.”

Study coauthors Giacomo Ciocca, a sexual psychology assistant professor at Rome’s Sapienza University, and Davide Doroldi, a clinical psychologist, told PsyPost that they were inspired to look into the possible link after observing higher rates of hypersexuality among people with ADHD.