Lifeboat Foundation

Summary: The dural sinuses and skull bone marrow serve as key communication hubs between the brain’s central immune system and the body’s peripheral immune system. These regions may act as “traffic lights,” allowing immune signals to flow between the brain and body, challenging the traditional view of the blood-brain barrier as an absolute divide.

Researchers found inflammatory activity in these areas correlates with inflammation in both the brain and body, offering new insights into conditions like depression. This discovery could pave the way for innovative treatments targeting these hubs to address immune-related conditions more precisely.

Scientists have developed the first electrically pumped continuous-wave semiconductor laser composed exclusively of elements from the fourth group of the periodic table—the “silicon group.”

Built from stacked ultrathin layers of silicon germanium-tin and germanium-tin, this new laser is the first of its kind directly grown on a silicon wafer, opening up new possibilities for on-chip integrated photonics. The findings have been published in Nature Communications. The team includes researchers from Forschungszentrum Jülich, FZJ, the University of Stuttgart, and the Leibniz Institute for High Performance Microelectronics (IHP), together with their French partner CEA-Leti.

The rapid growth of artificial intelligence and the Internet of Things are driving the demand for increasingly powerful, energy-efficient hardware. Optical data transmission, with its ability to transfer vast amounts of data while minimizing energy loss, is already the preferred method for distances above 1 meter and is proving advantageous even for shorter distances. This development points towards future microchips featuring low-cost photonic integrated circuits (PICs), offering significant cost savings and improved performance.

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Forest ecosystems of the future will have to cope with very different conditions to those of today. For this reason, researchers at the Technical University of Munich (TUM) state that a strategic approach to forest management is crucial. To this end, the research team has developed iLand: a simulation model that can compute long-term developments of large forest landscapes, right down to the individual tree—including disturbances from bark beetles to wildfires.

Charred tree trunks and blackened soil are typical of the desolation that a forest fire leaves behind. Inevitably, the question arises whether it will be possible to restore a green natural landscape. According to Rupert Seidl, Professor of Ecosystem Dynamics and Forest Management, this is possible, but the “how” decides how much the new forest will benefit the climate, nature and people.

“Today’s forest ecosystems are not particularly well adapted to future climate conditions,” says Seidl. “Over the next decades they will presumably come under increasing pressure from water shortage and insect pests, and may even die off. This is why it makes sense to use measures such as the reforestation of disturbed areas to strategically select tree species and take future developments into consideration.”

Therapeutic mRNAs offer great potential as a versatile and precise tool against cancer and other diseases. However, the therapeutic effectiveness is limited by the poor translation uptake of naked mRNA. To circumvent this challenge, researchers from VIB, VUB, Ghent University, and eTheRNA Immunotherapies developed an immunotherapeutic platform based on lipid-based nanoparticles (LNPs).

In different cancer models, applying a novel mixture of immunotherapeutic mRNA encapsulated in LNPs led to a clearly improved therapeutic efficacy with limited side effects. This proves the added value of the platform to the development of effective mRNA immunotherapies. The work is published in the journal Nature Communications.

The COVID-19 pandemic and recent Nobel Prize recognition have spotlighted mRNA therapies as a promising approach for diseases like cancer. With precision, scalability, and controlled immune activation, mRNA-based immunotherapy can encode proteins that stimulate the immune system to target and destroy cancer cells. Yet, naked mRNA is unstable, prone to degradation, and poorly absorbed by cells, limiting its effectiveness. This makes the development of reliable delivery methods essential for the future success of mRNA immunotherapies.

Don Pettit packed a home-made tracker to space, allowing him to bless our timelines with long-exposure images.

A new USC Stem Cell study published in the Proceedings of the National Academy of Sciences has identified key gene regulators that enable some deafened animals—including fish and lizards—to naturally regenerate their hearing. The findings could guide future efforts to stimulate the regeneration of sensory hearing cells in patients with hearing loss and balance disorders.

Led by first author Tuo Shi and co-corresponding authors Ksenia Gnedeva and Gage Crump at the Keck School of Medicine of USC, the study focuses on two cell types in the inner ear: the sensory cells that detect sound, and the supporting cells that create an environment where sensory cells can thrive.

In highly regenerative species such as fish and lizards, supporting cells can also transform into replacement sensory cells after injury—a capacity absent in humans, mice and all other mammals.

Researchers have developed a new computational method to explore the neutron matter inside neutron stars at densities higher than previously studied.

This method provides insights into the behavior of neutrinos during supernova explosions, enhancing the accuracy of simulations and potentially improving our understanding of such cosmic events.

Advances in Neutron Matter Simulation.

A team of scientists from the United States, Italy, and China may have finally explained a large gap in the African and Eurasian fossil record. According to a model in a study published August 31 in the journal Science, the population of human ancestors crashed between 800,000 and 900,000 years ago. They estimate that there were only 1,280 breeding individuals alive during this transition between the early and middle Pleistocene. About 98.7 percent of the ancestral population was lost at the beginning of this ancestral bottleneck that lasted for roughly 117,000 years, according to the study.

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