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Glial replication and proliferation support JC virus demyelination.

In HIV infected patients, JC virus (JCV) can cause a devastating demyelinating disease of the CNS known as progressive multifocal leukoencephalopathy (PML).

JCV replicates in human glial progenitor cells and astrocytes, which undergo viral T-antigen-triggered mitosis, enabling viral replication.

The authors were able to demonstrate that dividing human astrocytes supported JCV propagation to a substantially greater degree than did mitotically quiescent cells.

They also show that JCV infection greatly accentuated by cuprizone-induced demyelination and its associated mobilization of glial progenitor cells and triggered the death of both uninfected and infected glia, reflecting significant bystander death. https://sciencemission.com/JCV-infection-models

This scientific commentary refers to ‘JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation’ by Li et al. (https://doi.org/10.1093/brain/awae252).

Continue reading “Bridging the gaps between JCV infection models and human disease” | >

Howard Bloom, Dr. Ben Goertzel, and Dr. Mihaela Ulieru examine how principles of emergent intelligence in natural systems can inform artificial general intelligence (AGI) development.

Join us at the Beneficial AGI Summit & Unconference 2025 (May 26–28 in Istanbul) to learn more about these topics and collaborate on addressing the critical challenges of developing beneficial AGI. Register now to watch online or attend in-person: https://bgisummit.io/

/ 22517.global_brain.
https://en.wikipedia.org/wiki/Howard_… • A Cultural Legend Tackles the Benefic… 00:00 Intro 01:20 Howard Bloom’s Online Journey and the Global Brain 04:33 Ben Goertzel’s Perspective on the Global Brain 09:07 The Evolution of Intelligence and AI 12:42 Challenges and Philosophies in AI Development 17:56 Human Values and AI: A Complex Relationship 24:18 The Role of Compassion in AI and Human Evolution 29:31 Tribalism and Ethical Reasoning in AI 30:16 Emergence of AI Values 31:26 Self-Organization and Compassion in AI 32:21 Ethical Theories and AI Attractors 34:33 Future Economy and AI Impact 34:48 AI and Human Economy Transformation 35:44 Cosmic Ambitions and AI 37:15 Competition Among AIs 38:00 Vision of Beneficial AGI 38:20 Path to Human-Level AGI 42:32 Emergence and Cooperation in AI 46:17 Singularity and Human Nature 50:09 Punctuated Equilibrium in AI Development 52:27 Engineering the Future of Intelligence 54:22 Closing Thoughts on AI and the Future #AGI #AI #BGI — SingularityNET was founded by Dr. Ben Goertzel with the mission of creating a decentralized, democratic, inclusive and beneficial Artificial General Intelligence (AGI). According to Dr. Goertzel, AGI should be independent of any central entity, open to anyone and not restricted to the narrow goals of a single corporation or even a single country. The SingularityNET team includes seasoned engineers, scientists, researchers, entrepreneurs, and marketers. The core platform and AI teams are further complemented by specialized teams devoted to application areas such as finance, robotics, biomedical AI, media, arts and entertainment. Website: https://singularitynet.io X: https://twitter.com/SingularityNET Linkedin: / singularitynet Instagram: / singularitynet.io Discord: / discord Telegram: https://t.me/singularitynet WhatsApp: https://whatsapp.com/channel/0029VaM8… Warpcast: https://warpcast.com/singularitynet Bluesky: https://bsky.app/profile/singularityn… Github: https://github.com/singnet.
• A Cultural Legend Tackles the Benefic…

00:00 Intro.
01:20 Howard Bloom’s Online Journey and the Global Brain.
04:33 Ben Goertzel’s Perspective on the Global Brain.
09:07 The Evolution of Intelligence and AI
12:42 Challenges and Philosophies in AI Development.
17:56 Human Values and AI: A Complex Relationship.
24:18 The Role of Compassion in AI and Human Evolution.
29:31 Tribalism and Ethical Reasoning in AI
30:16 Emergence of AI Values.
31:26 Self-Organization and Compassion in AI
32:21 Ethical Theories and AI Attractors.
34:33 Future Economy and AI Impact.
34:48 AI and Human Economy Transformation.
35:44 Cosmic Ambitions and AI
37:15 Competition Among AIs.
38:00 Vision of Beneficial AGI
38:20 Path to Human-Level AGI
42:32 Emergence and Cooperation in AI
46:17 Singularity and Human Nature.
50:09 Punctuated Equilibrium in AI Development.
52:27 Engineering the Future of Intelligence.
54:22 Closing Thoughts on AI and the Future.

#AGI #AI #BGI

SingularityNET was founded by Dr. Ben Goertzel with the mission of creating a decentralized, democratic, inclusive and beneficial Artificial General Intelligence (AGI). According to Dr. Goertzel, AGI should be independent of any central entity, open to anyone and not restricted to the narrow goals of a single corporation or even a single country. The SingularityNET team includes seasoned engineers, scientists, researchers, entrepreneurs, and marketers. The core platform and AI teams are further complemented by specialized teams devoted to application areas such as finance, robotics, biomedical AI, media, arts and entertainment.

Continue reading “The Global Brain from Bacteria to AGI: The Evolution of Intelligence in the Conscious Cosmos” | >

A technology developed by the Brazilian company brain4care has been shown to be able to measure absolute values of intracranial pressure (ICP) more accurately than existing non-invasive methods. This is the result of a study published in the journal npj Digital Medicine by researchers from the University of São Paulo in Brazil, the University of Cambridge in the United Kingdom, Emory University in the United States, and the company itself.

“The study included the largest number of patients and showed that the technology we developed had the lowest error in estimating the value of intracranial pressure among all the non-invasive methods already available in the world,” Gustavo Frigieri, scientific director of brain4care and one of the authors of the study, told Agência FAPESP.

The technology developed by the Brazilian company consists of a sensor placed on the patient’s head that registers the nanometric expansions of the skull in each cardiac cycle and generates, in real time, a wave that indicates the variations in volume and intracranial pressure. The data obtained are processed by an artificial intelligence platform that generates reports to help doctors make decisions.

Read more | >

Converting one type of cell to another — for example, a skin cell to a neuron — can be done through a process that requires the skin cell to be induced into a “pluripotent” stem cell, then differentiated into a neuron. Researchers at MIT have now devised a simplified process that bypasses the stem cell stage, converting a skin cell directly into a neuron.

MIT researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuries or diseases such as ALS.

Read more | >

Awesome that Colossal is doing so well — and this is from before they announced their wooly mice accomplishment!

Colossal Biosciences, the company that’s famously on a mission to bring back the woolly mammoth and two other extinct species, has raised a $200 million Series C at a $10.2 billion valuation from TWG Global, the investment company of Guggenheim Partners co-founder Mark Walter and the billionaire Thomas Tull. The funding comes two years after the company closed its previous round at a reported valuation of $1.5 billion.

Why did investors pour so much capital at an eye-popping valuation for a company that has yet to generate any revenue and whose flagship projects, resurrecting an extinct mammoth and Tasmanian tiger, are not expected to be completed until 2028?

“The investor base has been very impressed with the speed at which we’ve created new technologies,” Ben Lamm, Colossal Biosciences’ co-founder and CEO, told TechCrunch.

Read more | >

Firefighters show higher rates of glioma-linked SBS42 mutational signatures associated with haloalkane exposure, suggesting occupational risk. The study highlights a clear link between firefighting, chemical exposure, and brain cancer mutations.

Read more | >

DNA holds the key to understanding life itself… From genetics and the human genome to gene editing, it shapes our health, evolution, and future… Discover how CRISPR, forensic science, and genetic engineering are transforming medicine… Explore the mysteries of ancient DNA, the role of the microbiome, and the promise of gene therapy… Personalized medicine is revolutionizing healthcare, allowing treatments tailored to our genetic code… Learn how hereditary diseases are being decoded and cured through biotechnology and DNA sequencing… The future of medicine depends on genetic research, but genetic ethics raise profound questions… The genome project has paved the way for DNA fingerprinting, cloning, and synthetic biology… With genetic modification, we are reshaping evolution itself… Will genetic testing lead to designer babies or eliminate genetic disorders? As gene therapy advancements push the limits of precision medicine, are we ready for these medical breakthroughs and DNA discoveries?

Sources.
Watson, J. D., & Crick, F. H. C. (1953). Nature, 171(4356), 737–738.
Collins, F. S., & McKusick, V. A. (2001). Science, 291(5507), 1215–1220.
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012). Science, 337(6096), 816–821.
Pääbo, S. (2014). Annual Review of Genetics, 38, 645–679.
Lander, E. S., Linton, L. M., Birren, B., et al. (2001). Nature, 409(6822), 860–921.

#DNABreakthroughs #GeneticsRevolution #HumanGenome #GeneTherapy #FutureOfMedicine.

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Longevity snapshot 7 — cellular rejuvenation protects neurons.

Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice.

Study reviewed:

In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis. Partial reprogramming with AAV2-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.

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