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Taxonomy of principal distances and divergences v/ Frank Nielsen.


We define duo Bregman divergences, duo Fenchel-Young divergences, duo Jensen divergences. We show how those divergences occur naturally when calculating the Kullback-Leibler divergence and skew Bhattacharyya distances between densities belonging to nested exponential families. We report the KLD between truncated normal distributions as a duo Bregman divergence. Demo code:

Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to “genome surgery.” These tools, including ones based on a natural system known as CRISPR/Cas9, offer enormous potential for addressing unmet clinical needs, underscored by the recent FDA approval of the first CRISPR/Cas9-based therapy.

A relatively new approach called “prime editing” enables gene-editing with exceptional accuracy and high versatility, but has a critical tradeoff: variable and often low efficiency of edit installation. In other words, while prime edits can be made with high precision and few unwanted byproducts, the approach also often fails to make those edits at reasonable frequencies.

In a paper that appeared in print in the journal Nature on April 18, 2024, Princeton scientists Jun Yan and Britt Adamson, along with several colleagues, describe a more efficient prime editor.