Lifeboat Foundation

Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function. The disease affects more than 12 million people worldwide, and many patients end up needing dialysis or a kidney transplant by the time they reach their 60s.

Researchers at MIT and Yale University School of Medicine have now found that a compound originally developed as a potential cancer treatment holds promise for treating ADPKD. The drug works by exploiting kidney cyst cells’ vulnerability to oxidative stress — a state of imbalance between damaging free radicals and beneficial antioxidants.

In a study employing two mouse models of the disease, the researchers found that the drug dramatically shrank kidney cysts without harming healthy kidney cells.

Join the discussion on this paper page.

Researchers have doubted how useful the AI protein-structure tool will be in discovering medicines — now they are learning how to deploy it effectively.

A stable, reactive, and cost-effective ruthenium catalyst for sustainable hydrogen production through proton exchange membrane water electrolysis.

Sustainable electrolysis for green hydrogen production is challenging, primarily due to the absence of efficient, low-cost, and stable catalysts for the oxygen evolution reaction in acidic solutions. A team of researchers has now developed a ruthenium catalyst by doping it with zinc, resulting in enhanced stability and reactivity compared to its commercial version. The proposed strategy can revolutionize hydrogen production by paving the way for next generation electrocatalysts that contribute to clean energy technologies.

Electrolysis and Catalyst Challenges.

Skoltech researchers and their colleagues from MIPT and China’s Center for High Pressure Science and Technology Advanced Research have computationally explored the stability of the bizarre compounds of hydrogen, lanthanum, and magnesium that exist at very high pressures. In addition to matching the various three-element combinations to the conditions at which they are stable, the team discovered five completely new compounds of hydrogen and either magnesium or lanthanum only.

Published in Materials Today Physics, the study is part of the ongoing search for room-temperature superconductors, the discovery of which would have enormous consequences for power engineering, transportation, computers and more.

“In the previously unexplored system of hydrogen, lanthanum, and magnesium, we find LaMg₃H₂₈ to be the ‘warmest’ superconductor. It loses electrical resistance below −109°C, at about 2 million atmospheres—not a record, but not bad at all either,” the study’s principal investigator, Professor Artem R. Oganov of Skoltech, commented.

In today’s paper, a unique gravitational wave event is re-examined as the possible origin of an AGN flare. What are the odds?

Your body’s cells use water to dissolve chemicals. It’s the same with all life on Earth. But could other fluids work as a solvent? A new paper reviews the potential for different liquid solvents to support life and proposes some surprising candidates, like liquid carbon dioxide, ammonia, and even concentrated sulfuric acid. Each of these solvents is liquid in dramatically different conditions, helping expand the possibilities for life as we don’t know it.

Originally published on Illumina News Center

Call it archaeology by other means. Rather than sifting through tons of dirt and carefully cataloguing human artifacts, Eske Willerslev and his colleagues have used Illumina NovaSeq Systems to sequence 5,000 ancient human genomes, revealing previously unseen historical nuance. This research tour de force, which is being published this month in four papers in the journal Nature, offers a rich view of early human migrations, mating habits, and disease variants, and their impact on modern Europeans.

“We wanted to sequence this ancient DNA so we could better understand human history,” says Willerslev, who is professor and director at the Centre of Excellence in GeoGenetics at the University of Copenhagen and the Prince Philip Professor of Ecology & Evolution at Cambridge University. “These results describe where we came from and why there’s so much variation in disease risk.”

Photonic integrated circuits have grown as potential hardware for neural networks and quantum computing, yet the tuning speed and large power consumption limited the application. Here, authors introduce the memresonator, a memristor heterogeneously integrated with a microring resonator, as a non-volatile silicon photonic phase shifter to address these limitations.