Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanism. They also highlight physical activity as a powerful stimulus to enhance physical performance and mitochondrial energetics throughout the human adult lifespan.
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
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