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The CRISPR-Cas9 system has revolutionised gene-editing, but cutting DNA isn’t all it can do. From turning gene expression on and off to fluorescently tagging particular sequences, this animation explores some of the exciting possibilities of CRISPR.

Download a poster on ‘The expanding CRISPR toolbox’ here: https://www.nature.com/posters/crispr…

Produced with support from Dharmacon: https://www.dharmacon.com.

Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors.

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Diagnosing dementia early gives us more time to put precautions in place and to study exactly how the condition progresses – and a new method for predicting conditions such as Alzheimer’s disease is promising up to nine years of advance warning.

The method, developed by a team from the Queen Mary University of London in the UK and Monash University in Australia, involves a neurobiological model that analyzes brain scans captured by functional magnetic resonance imaging, or fMRI.

In tests, the model was more than 80 percent accurate at predicting the development of dementia. That has huge potential in terms of early diagnosis, and it also addresses another challenge: the large number of people with dementia who don’t get diagnosed at all.

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Fifty-three years after a private plane carrying five men disappeared on a snowy Vermont night, experts believe they have found the wreckage of the long lost jet in Lake Champlain.

The corporate jet disappeared shortly after departing the Burlington airport for Providence, Rhode Island, on Jan. 27, 1971. Those aboard included two crew members and three employees of a Georgia development company Cousins Properties, who were working on a development project in Burlington.

Initial searches for the 10-seat Jet Commander turned up no wreckage and the lake froze over four days after the plane was lost. At least 17 other searches happened, until underwater searcher Garry Kozak and a team using a remotely operated vehicle last month found wreckage of a jet with the same custom paint scheme in the lake close to where the radio control tower had last tracked the plane before it disappeared. Sonar images were taken of the wreck found in 200 feet of water near Juniper Island.

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Promethium, one of the rarest and most mysterious elements in the periodic table, has finally given up some crucial chemical secrets.

By Mark Peplow & Nature magazine

One of the rarest and most mysterious elements in the periodic table has finally given up some crucial chemical secrets, eight decades after its discovery. Researchers at Oak Ridge National Laboratory in Tennessee have become the first to use radioactive promethium to make a chemical ‘complex’ — a compound in which it is bound to a few surrounding molecules. This feat of synthesis enabled the team to study how the element bonds with other atoms in a solution with water. Published May 22 in Nature the findings fill a long-standing gap in chemistry textbooks, and could eventually lead to better methods for separating promethium from similar elements in nuclear waste, for example.

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