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By 2050 we could get “10,000 years of technological progress”

Every major AI company has the same safety plan: when AI gets crazy powerful and really dangerous, they’ll use the AI itself to figure out how to make AI safe and beneficial. It sounds circular, almost satirical. But is it actually a bad plan? Today’s guest, Ajeya Cotra, recently placed 3rd out of 413 participants forecasting AI developments and is among the most thoughtful and respected commentators on where the technology is going.

She thinks there’s a meaningful chance we’ll see as much change in the next 23 years as humanity faced in the last 10,000, thanks to the arrival of artificial general intelligence. Ajeya doesn’t reach this conclusion lightly: she’s had a ring-side seat to the growth of all the major AI companies for 10 years — first as a researcher and grantmaker for technical AI safety at Coefficient Giving (formerly known as Open Philanthropy), and now as a member of technical staff at METR.

So host Rob Wiblin asked her: is this plan to use AI to save us from AI a reasonable one?

Ajeya agrees that humanity has repeatedly used technologies that create new problems to help solve those problems. After all:
• Cars enabled carjackings and drive-by shootings, but also faster police pursuits.
• Microbiology enabled bioweapons, but also faster vaccine development.
• The internet allowed lies to disseminate faster, but had exactly the same impact for fact checks.

But she also thinks this will be a much harder case. In her view, the window between AI automating AI research and the arrival of uncontrollably powerful superintelligence could be quite brief — perhaps a year or less. In that narrow window, we’d need to redirect enormous amounts of AI labour away from making AI smarter and towards alignment research, biodefence, cyberdefence, adapting our political structures, and improving our collective decision-making.

The plan might fail just because the idea is flawed at conception: it does sound a bit crazy to use an AI you don’t trust to make sure that same AI benefits humanity.

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Key alterations discovered in the cerebral cortex of people with psychosis

Researchers at the University of Seville have analyzed alterations in the cerebral cortex in people suffering from psychosis. Their findings show that psychosis does not follow a single trajectory, but rather its evolution depends on a complex interaction between brain development, symptoms, cognition and treatment. The authors therefore emphasize the need to adopt more personalized approaches that take individual differences into account in order to better understand the disease and optimize long-term therapeutic strategies.

Psychosis is a set of symptoms—such as hallucinations and delusions—that are common in schizophrenia and involve a loss of contact with reality. From their first manifestation, known as the first psychotic episode, these symptoms can appear and evolve in very different ways between individuals, thus making schizophrenia a particularly complex disorder.

The results of the study show that, at the time of the first episode, people with psychosis present a reduction in cortical volume, which is particularly marked in regions with a high density of serotonin and dopamine receptors, key neurotransmitters in both the pathophysiology of psychosis and the mechanism of action of antipsychotics. The data also suggest that both neurons and other brain cells involved in inflammatory and immunological processes may play an important role in the disease.

One stem cell generates 14 million tumor-killing NK cells in major cancer breakthrough

Scientists in China have unveiled a breakthrough way to mass-produce powerful cancer-fighting immune cells in the lab. By engineering early-stage stem cells from cord blood—rather than trying to modify mature natural killer (NK) cells—they created a streamlined process that generates enormous numbers of highly potent NK cells, including CAR-equipped versions designed to hunt specific cancers.

Phonon lasers unlock ultrabroadband acoustic frequency combs

Acoustic frequency combs organize sound or mechanical vibrations into a series of evenly spaced frequencies, much like the teeth on a comb. They are the acoustic counterparts of optical frequency combs, which consist of equally spaced spectral lines and act as extraordinarily precise rulers for measuring light.

While optical frequency combs have revolutionized fields such as precision metrology, spectroscopy, and astronomy, acoustic frequency combs utilize sound waves, which interact with materials in fundamentally different ways and are well-suited for various sensing and imaging applications.

However, existing acoustic frequency combs operate only at very high, inaudible frequencies above 100 kHz and typically produce no more than a few hundred comb teeth, limiting their applicability.

Symbiotic bacteria in planthoppers break record for smallest non-organelle genome ever found

Many insects rely on heritable bacterial endosymbionts for essential nutrients that they cannot get through their diet. A new study, published in Nature Communications, indicates that the genomes of these symbiotic bacteria often shrink over time. Some of these bacteria, which live inside certain insect cells, have lost so many genes that they have broken the record for the tiniest genome ever found—almost blurring the lines between organelle and bacteria.

Endosymbiotic relationships are common in many insects, and in sap-sucking insects, like planthoppers and cicadas, they are essential for the insect’s survival. Because the sap of plants does not typically contain certain amino acids or vitamins, the insect must get them another way. Over hundreds of millions of years, these insects have co-evolved with bacteria that provide these additional nutrients.

Sulcia and Vidania are two examples of bacterial endosymbionts, which have co-evolved with planthoppers for more than 260 million years. These bacteria live in specialized cells within the planthopper abdomen. The new study has found that, along with their hosts, these endosymbionts have evolved—or devolved—in some unexpected ways.

The persistence of gravitational wave memory

Neutron stars are ultra-dense remnants of massive stars that collapsed after supernova explosions and are made up mostly of subatomic particles with no electric charge (i.e., neutrons). When two neutron stars collide, they are predicted to produce gravitational waves, ripples in the fabric of spacetime that travel at the speed of light.

Gravitational waves typically take the form of oscillations, periodically and temporarily influencing the universe’s underlying fabric (i.e., spacetime). However, general relativity suggests that for some cosmological events, in addition to the oscillatory displacement of test masses (as produced by the passage of a gravitational wave train), there exists a final permanent displacement of them via a phenomenon referred to as “gravitational wave memory.”

Researchers at the University of Illinois at Urbana-Champaign, the Academy of Athens, the University of Valencia and Montclair State University recently carried out a study exploring the gravitational wave memory effects that would arise from neutron star mergers.

Atom-thin electronics withstand space radiation, potentially surviving for centuries in orbit

Atom-thick layers of molybdenum disulfide are ideally suited for radiation-resistant spacecraft electronics, researchers in China have confirmed. In a study published in Nature, Peng Zhou and colleagues at Fudan University put a communications system composed of the material through a gauntlet of rigorous tests—including the transmission of their university’s Anthem—confirming that its performance is barely affected in the harsh environment of outer space.

Beyond the protection of Earth’s magnetic field, the electronic components of modern spacecraft are extremely vulnerable to constant streams of cosmic rays and heavy ions. While onboard systems can be shielded with radiation-protective materials, this approach takes up valuable space and adds weight to spacecraft.

That extra mass drives up launch costs and can limit the payload available for scientific instruments or communications hardware. A far better solution would be to fabricate the electronics themselves from materials that are intrinsically resistant to radiation damage.

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