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The Defense Advanced Research Projects Agency has demonstrated a new mathematical framework that works to help researchers discover patterns in complex scientific and engineering systems. DARPA said Thursday researchers at Stanford University created algorithms designed to explore patterns in data in order to gain insights into network structure and function under the Simplifying Complexity in Scientific Discovery [ ].

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Nice callout of the Gates Foundation.


“Amaranth, Amaranto, love-lies-bleeding, tassel flower, Joseph’s coat, or ramdana (gods own grain) is the grain of well-being,” Shiva writes. (Photo: Elizabeth Weller/flickr/cc)

A recent report from the National Academy of Science of The United States, titled “Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values,” warns:

“One possible goal of release of a gene-drive modified organism is to cause the extinction of the target species or a drastic reduction in its abundance.”

A new “nano scalpel” enables scientists at DESY to prepare samples or materials with nanometre precision while following the process with a scanning electron microscope. The Focused Ion Beam, or FIB, microscope which has now gone into service also allows a detailed view of the inner structure of materials. The device was purchased by the University of Bayreuth, as part of a joint research project on the DESY campus funded by the Federal Ministry of Research. The FIB will be operated at the DESY NanoLab jointly with the University of Bayreuth.

“The microscope is not only able to examine microscopic defects, cracks or point-like corrosion sites underneath the surfaces of , but also to machine the surface of samples with extremely high precision, on a nanometre scale,” explains Maxim Bykov, project scientist from the University of Bayreuth. A nanometre is a millionth of a millimetre. The can be used to remove material as though it were a microscopic milling machine; as a result, the combined ion beam and electron microscope is particularly interesting for a wide range of applications in nanotechnology, materials science and biology.

“Apart from examining the structure of materials, the ability of the ion beam to remove material also leads to a wide range of different applications,” says Natalia Dubrovinskaia who is a professor at the University of Bayreuth and in charge of the joint research project (No. 05K13WC3). One example is the preparation of tiny diamond anvils, which are used to hold samples during ultra high-pressure experiments. The diamonds used for this are so small that there is no other way of preparing them. The ion beam allows so-called double-staged diamond anvil cells to be prepared with nanometre precision. The ultra high-pressure experiments are carried out at DESY’s Extreme Conditions Beamline (ECB) P02.2, headed by DESY scientist Hanns-Peter Liermann.

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Very cool; another example where nature inspires others. Einstein was inspired often by nature and its environment.


Titanium is used medically in applications such as artificial joints and dental implants. While it is strong and is not harmful to tissues, the metal lacks some of the beneficial biological properties of natural tissues such as bones and natural teeth. Now, based on insights from mussels—which are able to attach themselves very tightly to even metallic surfaces due to special proteins found in their byssal threads—scientists from RIKEN have successfully attached a biologically active molecule to a titanium surface, paving the way for implants that can be more biologically beneficial.

The work began from earlier discoveries that mussels can attach to smooth surfaces so effectively thanks to a protein, L-DOPA, which is known to be able to bind very strongly to smooth surfaces such as rocks, ceramics, or metals. Interestingly, the same protein functions in humans as a precursor to dopamine, and is used as a treatment for Parkinson’s disease.

Using a combination of recombinant DNA technology and treatment with tyrosinase, they were able to create a hybrid protein that contained active parts of both the growth factor and L-DOPA. Tests showed that the proteins were able to fold normally, and further experiments in cell cultures demonstrated that the IGF-1 was still functioning normally. Thanks to the incorporation of the L-DOPA, the team was able to confirm that the proteins bound strongly to the titanium surface, and remained attached even when the metal was washed with phosphate-buffered saline, a water-based solution. Zhang says, “This is similar to the powerful properties of mussel adhesive, which can remain fixed to metallic materials even underwater.”

Personally; I have heard this several years ago from some medical researchers. Glad that more have concluded this tie.


Genetic mutations on several genes including BRCA2 have been associated with prostate cancer; while in a separate study, a BRCA1 mutation has been linked to a particular form of uterine cancer.

The first study, published in the New England Journal of Medicine, found that 12 percent of men with advanced prostate cancer had inherited mutations in genes involved in the repair of damaged DNA.

Professor Johann de Bono of the Institute of Cancer Research in London and the Royal Marsden NHS Foundation Trust, who led the study, said: ‘Our study has shown that a significant proportion of men with advanced prostate cancer are born with DNA repair mutations – and this could have important implications for patients.

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Hmmm; okay.


As it turns out, the answer is not 42, it’s 42.3 — thousand. That’s how many discrete transistors spread across the 30 m2 room housing this massive computation machine. [James Newman’s] Megaprocessor, a seriously enlarged version of a microprocessor, is a project we’ve been following with awe as it took shape over the last couple of years.

[James] documented his work in great detail, and by doing so, took us on a journey through the inner workings of microprocessors. His monumental machine is now finished, and it’s the ultimate answer to how a processor – and pretty much everything that contains a processor – works.

Everyone of the ~42,300 transistors were hand-soldered to one of the massive PCBs, which look more like interactive circuit diagrams than actual circuit boards. This incredible amount of discrete transistors makes up the thousands of logic gates that eventually form the Megaprocessor’s registers, its arithmetic logic unit, its sequence control and also: its 256 bytes of RAM. Each logic gate displays the current IO state through LEDs, which also turns the RAM into a gigantic LED wall on which you can play Tetris. Despite its complexity, the Megaprocessor is pretty much self-documenting. [James] mounted all PCBs on large frames, which add up to a 10m long and 2m tall “computation display”. Detailed diagrams show the information flow between the functional blocks – and through the room.

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Nice read by Microsoft on their BMI efforts.


I have been reading a lot about brain interfaces and that the Tesla S can be summoned with the brain and that people have started having competitions with drones controlled by brain waves. I have recently acquired an Emotiv Insight® as shown in Figure 1 and have been doing some testing with it.

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Figure 1, brain interface Emotiv Insight® Microsoft Azure