Research from Linda Griffith’s laboratory group at MIT will be presented at SPIE Photonics West 2017.
The traditional path for most drugs is to start in a petri dish containing a single cell tissue culture, move to small animals such as rodents then on to primates, and finally on to clinical trials in humans. Along the path, every step could encounter results that deem the drug a failure and not suitable for the desired outcome.
In Brief
Engineers from Tufts University have just created a new, versatile material that could be optimized for a number of purposes, particularly within the medical field. The material was constructed out of special proteins called silk fibroins, and it can be programmed for specific biological, chemical, or mechanical tasks. The study was published online in Proceedings of the National Academy of Sciences (PNAS).
The team used water-based fabrication methods inspired by protein self-assembly to produce 3D bulk materials from silk fibroin. Fibroin, the structural protein that gives silk its durability, was chosen because it allowed for the easiest manipulation of the resulting substance’s form, as well as smoother modification of function. It’s also completely biodegradable.
A Harvard research team led by biologist Douglas Melton has retracted a promising research paper following multiple failed attempts to reproduce the original findings.
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Tufts University engineers have created a new format of solids made from silk protein that can be preprogrammed with biological, chemical, or optical functions, such as mechanical components that change color with strain, deliver drugs, or respond to light, according to a paper published online this week in Proceedings of the National Academy of Sciences (PNAS).
Using a water-based fabrication method based on protein self-assembly, the researchers generated three-dimensional bulk materials out of silk fibroin, the protein that gives silk its durability. Then they manipulated the bulk materials with water-soluble molecules to create multiple solid forms, from the nano- to the micro-scale, that have embedded, pre-designed functions.
For example, the researchers created a surgical pin that changes color as it nears its mechanical limits and is about to fail, functional screws that can be heated on demand in response to infrared light, and a biocompatible component that enables the sustained release of bioactive agents, such as enzymes.
KITCHENER — Just a few days are left to see Themuseum’s quantum exhibit before it packs up to tour the country.
Quantum: The Exhibition is at the downtown Kitchener museum until Jan. 1.
“It’s a really cool exhibit,” said David Marskell, Themuseum’s chief executive officer.
“It allows people to take a peek into the future.”
Well before the family came in to the Batson Children’s Specialty Clinic in Jackson, Mississippi, they knew something was wrong. Their child was born with multiple birth defects, and didn’t look like any of its kin. A couple of tests for genetic syndromes came back negative, but Omar Abdul-Rahman, Chief of Medical Genetics at the University of Mississippi, had a strong hunch that the child had Mowat-Wilson syndrome, a rare disease associated with challenging life-long symptoms like speech impediments and seizures.
So he pulled out one of his most prized physicians’ tools: his cell phone.
Using an app called Face2Gene, Abdul-Rahman snapped a quick photo of the child’s face. Within a matter of seconds, the app generated a list of potential diagnoses — and corroborated his hunch. “Sure enough, Mowat-Wilson syndrome came up on the list,” Abdul-Rahman recalls.
