The Large Electron-Positron collider returns to haunt the LHC.
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About eight years ago, as the controversy about research involving human embryonic stem cells was winding down and Barack Obama was about to take office, I had one of my regular lunches with a respected conservative policy expert. We had come to be friends who respectfully disagreed about embryonic stem cell research and other bioethics issues.
That day I told him that there were still bigger issues brewing that involved human reproductive materials. For example, the opponents of research that involved destroying human embryos had celebrated a new technology developed in Japan that turned regular adult cells into something resembling potent embryonic cells. What many failed to notice is that that same technology could be used to turn adult cells into human egg cells. Thus in theory two men could produce a baby with the second man’s sperm and without a woman to provide an egg.
“Oh,” my friend said when I pointed this out to him, “I would definitely support federal legislation to prevent that.” I was struck at his vehemence, but not surprised.
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Crystals are defined by their repeating, symmetrical patterns and long-range order. Unlike amorphous materials, in which atoms are randomly packed together, the atoms in a crystal are arranged in a predictable way. Quasicrystals are an exotic exception to this rule. First discovered in 1982, their atoms pack together in an orderly fashion, but in a mosaic-like pattern that doesn’t repeat and can’t be predicted from a small sample.
Being able to map out the position of individual atoms within a quasicrystal is a prerequisite for achieving a complete understanding of their structure and aids in designing them for specific applications, but conventional microscopy techniques don’t have the resolution to accomplish such a task.
In an effort to address this challenge, researchers from the University of Pennsylvania and the University of Michigan have engineered a quasicrystal that is formed by self-assembling nanoparticles, which are an order of magnitude larger than the atoms that comprise traditional quasicrystals. Their larger size enabled the team to use a suite of microscopy and simulation techniques to deduce, for the first time, the full three-dimensional configuration of a spontaneously formed quasicrystal.
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Tissue engineering makes further progress for repairing damaged joints.
Writing in The Lancet, Swiss doctors report that cartilage cells harvested from patients’ own noses have been used to successfully produce cartilage transplants for the treatment of the knees of 10 adults (aged 18–55 years) whose cartilage was damaged by injury. Two years after reconstruction, most recipients reported improvements in pain, knee function, and quality of life, as well as developing repair tissue that is similar in composition to native cartilage.
Despite this promising start, however, the effectiveness of the procedure needs to be rigorously assessed in larger randomised trials compared to conventional treatments and with longer follow up before any firm conclusions can be drawn about its use in routine clinical practice, say the authors.
Every year, around 2 million people across Europe and the USA are diagnosed with damage to articular cartilage because of injuries or accidents. Articular cartilage is the tissue on the end of a bone that cushions the surface of the joint and is vital for painless movement. Because the tissue doesn’t have its own blood supply, it has limited capacity to repair itself once damaged, leading to degenerative joint conditions like osteoarthritis. Traditional methods to prevent or delay onset of cartilage degeneration following traumatic events like microfracture surgery don’t create the healthy cartilage needed to endure the forces of everyday movement. Even novel medical advances using patients’ own articular cartilage cells (chondrocytes) have been unable to predictably restore cartilage structure and function in the long term. As the population ages and people live longer, there is an urgent and growing need to develop an effective therapy to repair cartilage damage.
