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A new genetic disease has been discovered that could play a key role in devastating brain conditions such as Alzheimer’s and Parkinson’s, opening up the possibility of new forms of treatment.

A 47-year-old Canadian woman, who had been having difficulty walking and balancing since she was 28, was found to have a new genetic disease after 10 known conditions were ruled out, according to a paper in the journal Nature by an international team of researchers.

The disease causes an over-reaction by the body’s natural repair system. An enzyme, known as PARP1, goes into over-drive, ultimately causing the deaths of brain cells.

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Senescent cell removal is the first true rejuvenation therapy to treat one of the aging processes and with human clinicial trials in the next 18 months these are some very exciting times. Here is yet another study showing natural compounds can be used in combination with drugs to kill senescent cells.

Today’s open access research paper outlines the discovery of yet another new candidate drug for the selective destruction of senescent cells. This is an increasingly popular research topic nowadays. Senescent cells perform a variety of functions, but on the whole they are bad news. Cells become senescent in response to stresses or reaching the Hayflick limit to replication. They cease further division and start to generate a potent mix of signals, the senescence-associated secretory phenotype or SASP, that can provoke inflammation, disarray the surrounding extracellular matrix structures, and change behavior of nearby cells for the worse. Then they destroy themselves, or are destroyed by the immune system — for the most part at least. This is helpful in wound healing, and in small doses helps to reduce cancer incidence by removing those cells most at risk of becoming cancerous. Unfortunately a growing number of these cells linger without being destroyed, more with every passing year, and their presence eventually causes significant dysfunction. That in turn produces age-related disease, frailty, and eventually death. Senescent cells are not the only root cause of aging, but they provide a significant contribution to the downward spiral of health and wellbeing, and even only their own would eventually produce death by aging.

The beneficial aspects of senescent cells seem to require only a transient presence, so the most direct approach to the problem presented by these cells is to destroy them every so often. Build a targeted therapy capable of sweeping senenscent cells from tissues, and make it efficient enough to keep the count of such cells low. That is the way to prevent senescent cells form contributing to age-related disease. Working in mice, researchers have produced results such as functional rejuvenation in aged lungs and extended life span through the targeted destruction of senescent cells. Since perhaps only a few percent of the cells in old tissue are senescent, this targeted destruction can be accomplished with few side-effects beyond those generated by off-target effects of the medication itself.

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A new biomarker for Alzheimers could improve the patient outcome and allow for earlier treatment.

An enzyme found in the fluid around the brain and spine is giving researchers a snapshot of what happens inside the minds of Alzheimer’s patients and how that relates to cognitive decline.

Iowa State University researchers say of the enzyme, autotaxin, significantly predict impairment and Type 2 diabetes. Just a one-point difference in autotaxin levels — for example, going from a level of two to a three — is equal to a 3.5 to 5 times increase in the odds of being diagnosed with some form of memory loss, said Auriel Willette, an assistant professor of food science and human nutrition at Iowa State.

Autotaxin, often studied in cancer research, is an even stronger indicator of Type 2 diabetes. A single point increase reflects a 300 percent greater likelihood of having the disease or pre-diabetes. The results are published in the Journal of Alzheimer’s Disease. Willette and Kelsey McLimans, a graduate research assistant, say the discovery is important because of autotaxin’s proximity to the .

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Even in the best case, automation leaves the first generation of workers it displaces in a lurch because they usually don’t have the skills to do new and more complex tasks, Mr. Acemoglu found in a paper published in May.

Robert Stilwell, 35, of Evansville, Ind., is one of them. He did not graduate from high school and worked in factories building parts for tools and cars, wrapping them up and loading them onto trucks. After he was laid off, he got a job as a convenience store cashier, which pays a lot less.

“I used to have a really good job, and I liked the people I worked with — until it got overtaken by a machine, and then I was let go,” he said.

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The first pioneers on Mars may build their homes using the ice beneath their feet.

In November, a University of Texas research team reported that Mars’ Utopia Planitia region contains about as much water, in the form of buried ice, as Lake Superior does here on Earth.

This ice layer, which spans a greater area than the state of New Mexico, lies in Mars’ mid-northern latitudes and is covered by just 3 feet to 33 feet (1 to 10 meters) of soil, the scientists determined. [Photos: The Search for Water on Mars].

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Dr. Chen Yue, Director of Commercial Satellite Technology for the China Academy of Space Technology (CAST) announced on December 10, 2016 that not only has China successfully tested EmDrives technology in its laboratories, but that a proof-of-concept is currently undergoing zero-g testing in orbit (according to the International Business Times, this test is taking place on the Tiangong 2 space station).

Scientists with the China Academy of Space Technology claim NASA’s results ‘re-confirm’ what they’d already achieved, and have plans to implement it in satellites ‘as quickly as possible.’

‘The establishment of an experimental verification platform to complete the milli-level micro thrust measurement test, as well as several years of repeated experiments and investigations into corresponding interference factors, confirm that in this type of thruster, thrust exists.’

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ExoMars will soon start aerobraking in Mars orbit in a years-long effort to sample Mars super-thin lower atmosphere in the ongoing search for trace gases indicative of life and active geology.

ESA’s ExoMars Trace Gas Orbiter is preparing to aerobrake into parts of the unexplored Martian lower atmosphere in search of methane, water vapor and other possible signatures of life on the Red Planet.

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