Lifeboat Foundation

A study of the embryonic nervous system of the fruit fly throws light on how two neuronal cell lineages that develop at different times and in different places in the ventral nerve cord of the embryo can ultimately result in very similar neuronal subtypes. The study, publishing in the Open Access journal PLOS Biology on 5th May, is a collaboration between research teams in Madrid (Spain) and Linköping (Sweden).

In the paper, Hugo Gabilondo, Johannes Stratmann and their colleagues report that a crucial terminal selector gene, col, is activated by different sets of spatio-temporal selector genes in the two different neuronal cell lineages. In dAp neurons, which are present throughout the thorax and abdominal segments, col is activated directly by the action of the early temporal genes Kruppel (Kr) and pdm, and the GATA transcription factor gene grain (grn). By contrast, in Tv1 neurons, which are specific to the thoracic segments, col is activated by the late temporal gene cas, together with several other genes that feed forward onto the terminal selector gene cascade downstream of col. The result is expression of the neuropeptide Nplp1 in both dAp and Tv1 neurons.

The developing nervous system generates many different neuronal cell types; understanding this process of cell fate specification remains a major challenge for biologists. Complex cascades of regulatory genes are known to be involved, starting with spatial and temporal selector genes and finishing with terminal selector genes, all of which act in various combinations to dictate the ultimate neuronal cell type. A particular neuronal cell type often arises in several parts of the nervous system and at different stages of development, however, suggesting that different spatio-temporal cues can converge on the same terminal selectors to generate a similar cell fate. This study reports evidence of this phenomenon in an example from the fruit fly, Drosophila melanogaster.

Continue reading “Gene cascade specifies two distinct neuron sets expressing Nplp1” »

Dilated cardiomyopathy (DCM) is a progressive thinning of heart muscle that commonly results in heart failure. DCM is a known secondary complication of conditions such as alcohol abuse and infection and is also an inherited disorder. However, the.

Nice

J.E. Moss Elementary School, a Title I school in Nashville, TN, has adopted an augmented reality program to help improve reading skills in one of its kindergarten classes.

Letters alive, a supplemental reading software kit from Alive Studios, has aided teacher Greg Smedley-Warren and boosted his kindergarten class’ literacy scores above all the other kindergarten classrooms in his school, according to a prepared statement. His class includes several ELL and “at risk” students.

Continue reading “Nashville School Uses Augmented Reality” »

Using bacteria to aid in the design of superior biomedical implants capable of resisting colonization by infectious bugs.

Dr. Pushkar Lele, assistant professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, is developing novel insights in cellular mechanics with bacteria to aid in the design of superior biomedical implants capable of resisting colonization by infectious bugs. Lele’s group also focuses on unraveling the fundamental principles underlying interactions in biological soft-matter to build bio-nanotechnology-based molecular machines. Lele’s lab currently focuses on a unique electric rotary device found in bacteria — the flagellar motor.

According to Lele, it is well established how motile bacteria employ flagellar motors to swim and respond to chemical stimulation. This allows bacteria to search for nutrients and evade harmful chemicals. However, in his recent work, Lele has now demonstrated that the motor is also sensitive to mechanical stimulation and identified the protein components responsible for the response. Sensing initiates a sensitive control of the assemblies of numerous proteins that combine to form the motor. Control over motor assemblies facilitates fine-tuning of cellular behavior and promotes chances of survival in a variety of environments.

Continue reading “Lele flagella motor research develops novel insights in cellular mechanics” »

Of course; makes sense.

DARPA hopes it can ‘fingerprint’ individual cyberattackers and build a picture of their handiwork over time.

Science proving that Alpha males still capture their mates — glad to see how science has gone backwards.

Males who evolve in male-dominated populations become far better at securing females than those who grow up in monogamous populations, according to new research into the behaviour of fruit flies at the University of Sheffield.

The study, led by Dr Allan Debelle and Dr Rhonda Snook in the University’s Department of Animal and Plant Sciences, looked at the mating patterns of fruit flies after they evolved for 100 generations in either polyandrous populations (where several males have to compete for a single female) and monogamous populations (where each male has access to only one female).

Continue reading “‘Super males’ emerge from male-dominated populations, study finds” »

Nice.

Interesting approach.

If you’re at all interested in your health, it’s likely you’ve joined the 20 percent of Americans who’ve incorporated fitness trackers into their daily ensemble. From monitoring steps and daily activity to sleep, an ever-growing number of devices are tracking and analyzing our body’s data in an effort to make us better.

But how good is this tracking? Despite noble intentions, the scientific reality is that much of the data these trackers provide is insufficient and inaccurate — and in turn, are not as effective as they promise.

Continue reading “Use Your Brain. Ditch Your Fitness Tracker” »

Left hemisphere of J. Piłsudski’s brain, lateral view.

A new study has found that a faster metabolism is the main reason that humans were able to evolve bigger brains than other closely related apes. Humans burned 635 more calories per day than gorillas, and a whopping 820 more calories per day than the orangutans in the study.

Although the study findings seem promising, more research on the issue is required since the research was performed only on adults.

Continue reading “Humans Are Fatter Than Primates, But It Fuels Our Bigger Brains” »