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Dr. Matthew O’Connor from the SENS Research Foundation gives a fascinating talk about this years successful results of the mitochondrial repair project (MitoSENS) and the potential for repairing age-related damage to the mitochondria that SENS proposes. 2017 could be an even better year for progress, please consider donating to the SRF Winter Fundraiser and help them make age-related disease a thing of the past.


Please take a few minutes to watch SENS Research Foundation’s Matthew O’Connor give a Google TechTalk during Google’s Giving Week campaign. The topic is his recently published article on our MitoSENS Research. If you enjoy this presentation and support our work please go to our website and donate today. Your support is critical to our success. You can donate at www.sens.org/donate

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The team showed that a new form of gene therapy produced a remarkable rejuvenating effect in mice. After six weeks of treatment, the animals looked younger, had straighter spines and better cardiovascular health, healed quicker when injured, and lived 30% longer.

Juan Carlos Izpisua Belmonte, who led the work at the Salk Institute in La Jolla, California, said: “Our study shows that ageing may not have to proceed in one single direction. With careful modulation, ageing might be reversed.”

The genetic techniques used do not lend themselves to immediate use in humans, and the team predict that clinical applications are a decade away. However, the discovery raises the prospect of a new approach to healthcare in which ageing itself is treated, rather than the various diseases associated with it.

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Excellent article by Nick Gillespie, Editor-in Chief of Reason. Genetic editing is so far the 21st Century’s most important science—and it’s already being challenged by many as too radical: http://reason.com/blog/2016/12/15/will-gene-editing-technologies-spark-the #transhumanism #CRISPR #Future


The folks behind CRISPR gene editing were runners-up for Time’s Person of the Year. Their creation may win the future for secular China.

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It is looking increasingly likely the mysterious Google Calico have very modest ambitions regarding increased lifespans for humans given the comments made by Dr. Aubrey de Grey and others and the direction they are taking with their research. Modest increases of lifespan over the kind of robust therapies of SENS seems pretty dissapointing.


More about Google Calico and their aim to modestly increase lifespan. People like Dr. Aubrey de Grey and Nathaniel David from rising biotech star Unity.

“To some, Calico’s heavy bet on basic biology is a wrong turn. The company is “my biggest disappointment right now,” says Aubrey de Grey, an influential proponent of attempts to intervene in the aging process and chief science officer of the SENS Research Foundation, a charity an hour’s drive from Calico that promotes rejuvenation technology. It is being driven, he complains, “by the assumption that we still do not understand aging well enough to have a chance to develop therapies.” Indeed, some competitors are far more aggressive in pursuing interventions than Calico is.

They are very committed to these fundamental mechanisms, and bless them for doing that. But we are committed to putting drugs into the clinic and we might do it first,” says Nathaniel David, president and cofounder of Unity Biotechnology. This year, investors put $127 million behind Unity, a startup in San Francisco that’s developing drugs to zap older, “senescent” cells that have stopped dividing. These cells are suspected of releasing cocktails of unhelpful old-age signals, and by killing them, Unity’s drugs could act to rejuvenate tissues. The company plans to start with a modestly ambitious test in arthritic knees. De Grey’s SENS Foundation, for its part, has funded Oisin Biotechnologies, a startup aiming to rid bodies of senescent cells using gene therapy.”

Westworld recently wrapped its first season with a few stunning twists and a stunning statistic: With a 12-million-viewer average, it was the most-watched first season of an original HBO show in the network’s history. Westworld concerns a perverse theme park, styled in the fashion of the American Old West. The park’s “hosts,” artificially intelligent beings physically indistinguishable from humans, begin to remember the horrifying experiences inflicted on them by the park’s “guests,” the humans who pay to visit and do as they please, including raping and killing hosts.

Robert Ford (Anthony Hopkins), the fictional cofounder of Westworld, built the park’s hosts with the ability to improvise and make decisions based on their environment—a vision of AI strikingly similar to the one held by Simon Stringer, the director of the Oxford Centre for Theoretical Neuroscience and Artificial Intelligence. Stringer is one of the field’s leading thinkers, and like Ford, he says machines with some internalized spatial and causal model of the world could achieve an intuitive, human-like intelligence.

In my conversation with Stringer about Westworld, we discussed what makes AI seem human, the potential threat AI poses to humans, the role of self-modifying programming, and the importance of the Turing Test.

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San Francisco (AFP) — Mark Zuckerberg envisions a software system inspired by the “Iron Man” character Jarvis as a virtual butler managing his household.

The Facebook founder’s dream is about artificial intelligence, which is slowly but surely creeping into our daily lives, no longer just science fiction.

Artificial intelligence or AI is getting a foothold in people’s homes, starting with the Amazon devices like its Echo speaker which links to a personal assistant “Alexa” to answer questions and control connected devices such as appliances or light bulbs.

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