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Researchers at University of California, Santa Barbara, have designed a functional nanoscale computing element that could be packed into a space no bigger than 50 nanometres on any side.

red blood cell nanotechnology nanotech future timeline

In 1959, renowned physicist Richard Feynman, in his talk “Plenty of Room at the Bottom” spoke of a future in which tiny machines could perform huge feats. Like many forward-looking concepts, his molecule and atom-sized world remained for years in the realm of science fiction. And then, scientists and other creative thinkers began to realise Feynman’s nanotechnological visions.

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Get ready to have your mind blown. According to an experiment led by two physicists in Australia, reality doesn’t exist. Turn on, tune in, and drop out man, because the world as you know it is all kinds of weird, at least on a quantum level.

Andrew Truscott and Roman Khakimov of The Australian National University used atoms to put a John Wheeler delayed-choice thought experiment to practical use. The Wheeler thought experiments ask, in theory, at what point does an object decide to act like one thing or another.

Truscott and Khakimov’s team used what is assumed to be extremely expensive and complex scientific equipment to trap a single helium atom and then drop it through a pair of laser beams that formed a scattered grating pattern.

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You have the power to change the future of medicine and how we treat age-related diseases. Here is an example of how grassroots fundraising is changing science.


Joining the circulatory system of an old with a young animal has been shown to rejuvenate old tissues. Here the authors describe a comparatively simple blood infusion system that allows for the controlled exchange of blood between two animals, and study the effects of a single exchange on various tissues.

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The CellAge AMA is open for questions, come along and ask about biotechnology, senolytics and so on.


Welcome to the CellAge AMA with Mantas Matjusaitis, PhD student in synthetic biology and founder of CellAge. I am here to talk about our work to improve the targeting of dysfunctional “senescent” cells in the body, and thereby aid in their eventual removal. This is important because removal of these cells has been shown to be a critical component in the effort to improve healthy human lifespan.

In short, CellAge is going to develop synthetic DNA promoters which are specific to senescent cells, as the promoters that are currently used for this purpose, such as the p16 gene promoter, suffer from various issues and limitations (not comprehensively targeting all senescent cells, collateral damage in targeting some cells that are not senescent, etc.). You can find more details in our technology video here, and on our Lifespan.io information page.

Seeing as our primary mission is to expand the interface between synthetic biology and aging research, as well as drive translational research forward, we will offer the senescence reporter assay we develop to academics for free. We predict that in the very near future this assay will be also used as a quality control step in the cell therapy manufacturing process to make cell therapies safer.

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In Brief

  • Facebook billionaire Mark Zuckerberg recently opened his wallet in order to create BioHub, a $600 million center that will focus on working to create a human cell directory.
  • By mapping the trillions of cells in the human body, experts would be able to develop new drugs and vaccines to combat — and potentially end — disease.

Last month, we reported on the Human Cell Atlas, a project that plans to provide a detailed reference map of the human body’s trillions of cells. Yes, trillions. Once completed, the project could revolutionize healthcare by giving doctors and researchers a better way to predict, diagnose, and treat diseases.

Initiatives like this need funding – so Facebook billionaire Mark Zuckerberg opened his wallet and founded BioHub, a $600 million center that will focus on helping create a human cell directory. Zuckerberg and his wife, Priscilla Chan, plan to give away $3 billion over 10 years to fight disease, and BioHub is the couple’s first initiative.

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Introduction

Moore’s Law says that the number of transistors per square inch will double approximately every 18 months. This article will show how many technologies are providing us with a new Virtual Moore’s Law that proves computer performance will at least double every 18 months for the foreseeable future thanks to many new technological developments.

This Virtual Moore’s Law is propelling us towards the Singularity where the invention of artificial superintelligence will abruptly trigger runaway technological growth, resulting in unfathomable changes to human civilization.

Going Vertical

In the first of my “proof” articles two years ago, I described how it has become harder to miniaturize transistors, causing computing to go vertical instead. 2 years ago, Samsung was mass producing 24-layer 3D NAND chips and had announced 32-layer chips. As I write this, Samsung is mass producing 48-layer 3D NAND chips with 64-layer chips rumored to appear within a month or so. Even more importantly, it is expected that by the end of 2017, the majority of NAND chips produced by all companies will be 3D. Currently Samsung and its competitors are working 24/7 to transform their 2D factories to 3D factories causing a dramatic change in how NAND flash chips are created.

48-layers-samsung

Cross section of 48-layer 3D NAND chip (Learn more!)

Going Massively Parallel

Moore’s law only talks about the number of transistors per square inch. It doesn’t directly mean that a chip will run any faster. Unfortunately, since 2006 Intel’s CPUs have dramatically slowed their increase in performance, averaging about 10% a year. The cause of this problem is that the average Intel CPU only has 2 to 4 cores and it has become difficult to speed up these cores.

Nvidia has been promoting a different architecture, which averages thousands of cores. In 2016, they had a HUUGE success with this idea causing their company to soar in value with the market capitalization of Nvidia reaching about one third of Intel’s value. (This is impressive as Intel is a very profitable company with profits exceeding $15 billion in 2015.)

titan-x-pascal

Titan X Pascal is 566% faster at AI than last year’s model!

Exactly what did Nvidia achieve? Their new Titan X runs AI instructions 566% faster than the old Titan X card that was only released a year earlier. Also, Nvidia got a half-size version of their Drive PX 2 put in all Tesla cars and this chip is about 4000% faster than the chip it replaced. Finally, Nvidia is working on a successor to the Drive PX 2 chip called Xavier that is rumored to come out in about a year and to be at least 400% more energy efficient than the current chip.

These numbers of 566%, 4000%, and 400% are much bigger than Intel’s 10% and are causing a fundamental change in how computing is done. It is worth noting that Nvidia’s main competitor AMD has also been blowing past Intel’s 10% annual performance gains so the idea of many cores has been proven by multiple companies. In fact, even the graphical part of Intel’s chips has been blowing past this 10% performance gain per year.

Thousands of programs have been designed to take advantage of this parallel computing performance. For example, the program BlazingDB runs over 100 times as fast as MySQL which was only designed to run on CPUs. As the performance gap increases between a standard CPU with a handful of cores and a GPU with thousands of cores, more and more programs are being written to take advantage of GPUs. And the growing market for massively parallel chips means that Nvidia can now afford to spend lots of money in making their chips better. For example, their latest generation of chips called Pascal cost over $2 billion to develop. (All this money goes into making a better chip design, Nvidia doesn’t actually build chips. They currently use TSMC and Samsung for that.)

Lightning-Fast Data

For a long time, data for programs was stored on slow hard drives. Then it was moved to SATA SSDs which rapidly sped up each year until they finally hit the bandwidth limits of the SATA standard. Now data is moving to PCIe SSDs that currently have 6 times the bandwidth of SATA drives with even faster PCIe drives planned. (A PCIe drive that used 16 lanes like a graphics card would have 4 times the bandwidth of current PCIe drives.) Both Intel’s coming Optane 3D XPoint SSDs and Samsung’s Z-NAND SSDs are examples of such faster PCIe drives and a handful of enterprise SSDs already exist that use 16 lanes.

Even faster than all these drives is the idea of storing everything in memory which is becoming more and more common. When Watson won at Jeopardy in 2011, it used the trick of using its 16 terabytes of RAM to store everything in memory instead of using its drives during the competition. Today Samsung sells 2.5D memory cards that hold 128GB each.

Intel’s Xeons with the highest memory capacity can handle 3 terabytes of memory per chip and motherboards are being sold that can hold 3 terabytes of Samsung’s 2.5D memory. 2.5D means that four layers of chips are “soldered” on top of each other. (Cheaper non-Xeon systems now hold as much as 128GB 2D memory which is pretty good for a home computer.)

Computers Programming Computers

computer-programming

Nvidia’s CEO Jen-Hsun Huang said, “AI is going to increase in capability faster than Moore’s Law. I believe it’s a kind of a hyper Moore’s Law phenomenon because it has the benefit of continuous learning. It has the benefit of large-scale networked continuous learning. Today, we roll out a new software package, fix bugs, update it once a year. That rhythm is going to change. Software will learn from experience much more quickly. Once one smart piece of software on one device learns something, then you can over-the-air (OTA) it across the board. All of a sudden, everything gets smarter.”

Computers Designing Chips

Since the mid-1970s, programs have been used to design chips as chips have become too complicated for any team of humans to handle. (Nvidia’s Tesla P100 GPUs have 150 billion transistors when you include the memory “soldered” to the top of them!)

A quantum leap in chip design may happen in the near future as Nvidia recently built a supercomputer for internal research out of mainly Nvidia Tesla P100 GPUs. This supercomputer was ranked 28 out of all computers in the world. What will this computer be used for?

Nvidia said, “We’re also training neural networks to understand chipset design and very-large-scale-integration, so our engineers can work more quickly and efficiently. Yes, we’re using GPUs to help us design GPUs.”

This is a very interesting area to watch as today’s chips are so complicated that they are likely very inefficient with massive speedups being available if we could find a better way to optimize them. An example of the gains possible is that Nvidia got about a 50% performance increase between its Kepler and Maxwell generations despite both microarchitectures using the same 28nm technology.

Conclusion

The new Virtual Moore’s Law is already having a massive effect. Jen-Hsun said, “By collaborating with AI developers, we continued to improve our GPU designs, system architecture, compilers, and algorithms, and sped up training deep neural networks by 50x in just three years — a much faster pace than Moore’s Law.”

With chips going vertical, chip architectures going massively parallel, lightning-fast data, computers programming computers, and computers designing chips, the Singularity is closer than you think!

Technical Note for Geeks

Here is what I actually meant by “soldered”:

Conventional chip packages interconnect die stacks using wire bonding, whereas in TSV packages, the chip dies are ground down to a few dozen micrometers, pierced with hundreds of fine holes and vertically connected by electrodes passing through the holes, allowing for a significant boost in signal transmission. TSV stands for Through-Silicon Vias.

Excellent overview on BMI technology.


Less than a century ago, Hans Berger, a German psychiatrist, was placing silver foil electrodes on his patients’ heads and observing small ripples of continuous electrical voltage emerging from these. These were the first human brain waves to ever be recorded. Since Hans Berger’s first recordings, our knowledge on the brain structure and function has developed considerably. We now have a much clearer understanding of the neuronal sources that generate these electrical signals and the technology that is now available allows us to get a much denser and accurate picture of how these electrical signals change in time and across the human scalp.

The recording and analysis of brain signals has advanced to a level where people are now able to control and interact with devices around them with the use of their brain signals. The field of brain-computer interfaces has in fact garnered huge interest during the past two decades, and the development of low-cost hardware solutions together with the continuously evolving signal analysis techniques, have brought this technology closer to market than ever before.

Research in the field of brain-computer interfaces was primarily propelled by the need of finding novel communication channels for individuals suffering from severe mobility disorders as in the case of patients with locked-in syndrome. People suffering from the condition have a perfectly functioning brain but are trapped inside their body, which no longer responds to the signals being transmitted from their brain.