Lifeboat Foundation

Groundbreaking research led by a global group of over 100 researchers will enable a more in-depth exploration of human genetic variation as fully sequencing the Y chromosome, a feat that has challenged scientists for years, has been accomplished for the first time. In this interview, we speak to Dylan Taylor about this impactful research and how it may shape our understanding of human genetics.

Please could you introduce yourself and your current research activities?

I am Dylan Taylor, a Ph.D. candidate and NIH F31 fellow in the Department of Biology at Johns Hopkins University. My work with the T2T consortium focuses on exploring how a complete reference genome can improve our ability to study human genetic variation and how it impacts human traits and health.

Polyploidization-rediploidization process plays an important role in plant adaptive evolution. Here, the authors assemble the genomes of mangrove species Sonneratia alba and its inland relative Lagerstroemia speciosa, and reveal genomic evidence for rediploidization and adaptive evolution after the whole-genome triplication.

The development of RNA technologies demands accurate assessment of transcript size and heterogeneity. Here, authors report a nanopore-based approach to study full-length RNA transcripts at the single-molecule level, identify premature transcription termination and study rolling-circle transcription.

René Descartes’ mind-body dualism—the view that the mind and body are different kinds of things—haunts cognitive science to this day.

I have written a lot about vaccines that treat cancer. Now we have another new mRNA vaccine to treat pancreatic cancer that has shown promising results in phase 1 clinical trials and is now entering a larger phase 2 clinical trial. This is exciting news for a deadly cancer that attacks tens of thousands of people each year.

The mRNA vaccine technology is going to be one of the leading technologies for cancer treatments going forward. If it can make a meaningful dent in the course of pancreatic cancer, it may well become one of the primary tools for oncologists in treating this pernicious disease.

As I usually do, let’s review this vaccine and the clinical trial results.

[NEW POST] Most research on the role of gut microbiota in the gut-brain axis has focused on bacteria, while fungi living inside the gut have been overlooked. What do we know about the role of gut fungi in the communication between the gut and the brain?

New mathematical models of our Milky Way Galaxy are helping a team of Argentine, Chilean and Spanish astrophysicists trace the origins of our galaxy back through time.

A new study published in Nature Astronomy describes the most luminous object ever observed by astronomers. It is a black hole with a mass of 17 billion Suns, swallowing a greater amount of mass than the sun every single day.

It has been known about for several decades, but since it is so bright, astronomers assumed it must be a nearby star. Only recent observations revealed its extreme distance and luminosity.

The object has been dubbed J0529-4351. This name simply refers to its coordinates on the celestial sphere—a way of projecting the objects in the sky onto the inside of a sphere. It is a type of object called a quasar.

Miotto et al. show that in mice, liver-derived extracellular vesicles act on skeletal muscle and the pancreas and increase glucose effectiveness and insulin secretion, thereby modulating glycaemic control.