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Bird flu persists in raw milk cheese, study demonstrates

Raw milk cheese products contained infectious avian influenza virus when made with contaminated raw milk, creating potential health risks for consumers, according to a new study.

At the same time, no virus was detected in test samples of highly acidic raw milk cheese. Feta cheese is an example of a more acidic variety.

The study is published in Nature Medicine.

Novel immunotherapy combination destroys colorectal liver metastases

Advanced colon cancer is the leading cause of cancer-related death in young American men and the second highest worldwide. In the majority of these patients, as the cancer advances it metastasizes to the liver. Despite progress in surgical therapies aimed at eradicating the cancer, many of these patients will have tumor recurrence in the liver.

Now, researchers from UC San Francisco (UCSF), have discovered that a novel combination of immunotherapies can reprogram the immune environment of colon cancer tumors that spread to the liver. In preclinical models, this therapy often eliminated tumors entirely, offering a potential new path for treating patients with advanced colorectal cancer.

Their study appears in Science Advances.

Sam Altman on Zero-Person AI Companies, Sora, AGI Breakthroughs, and more

OpenAI just unveiled HUGE developer updates at DevDay 2025 — Apps in ChatGPT, Agent Builder, Sora API, and Codex updates that can handle day-long tasks.

I sat down with Sam Altman for an exclusive interview about going viral on Sora, zero-person companies, and why he believes early AGI-like breakthroughs are starting to happen NOW.

In this conversation, we unpack:

Sam’s Sora AI deepfakes going viral.
Zero-person billion dollar companies run by agents.
AI starting to make scientific discoveries on Twitter.
ChatGPT’s 800M users and the new distribution platform.

Get 5-minute daily updates on the latest AI news: https://www.therundown.ai/subscribe.

Chapters:

Scientists are collecting toenail clippings to reveal radon exposure and lung cancer risk

At 47 years of age, Emi Bossio was feeling good about where she was. She had a successful law practice, two growing children and good health. Then she developed a nagging cough. The diagnosis to come would take her breath away.

“I never smoked, never. I ate nutritiously and stayed fit. I thought to myself, I can’t have lung cancer,” says Bossio. “It was super shocking. A cataclysmic moment. There are no words to describe it.”

Bossio had to give up her law practice to focus on treatment and healing. As part of that journey, she’s taken on a new role as an advocate to increase awareness about lung cancer. She still has no idea what caused her lung cancer. Trying to answer that question is how Bossio became interested in the research Dr. Aaron Goodarzi, Ph.D., is doing at the University of Calgary.

Novel AI tool opens 3D modeling to blind and low-vision programmers

Blind and low-vision programmers have long been locked out of three-dimensional modeling software, which depends on sighted users dragging, rotating and inspecting shapes on screen.

Now, a multiuniversity research team has developed A11yShape, a new tool designed to help blind and low-vision programmers independently create, inspect and refine three-dimensional models. The study is published on the arXiv preprint server.

The team consists of Anhong Guo, assistant professor of electrical engineering and computer science at the University of Michigan, and researchers from the University of Texas at Dallas, University of Washington, Purdue University and several partner institutions—including Gene S-H Kim of Stanford University, a member of the blind and low-vision community.

Synaptic Dysfunction in Dementia Can Be Modelled in Patient-Derived Neurons

Neurons produced from frontotemporal dementia patients’ skin biopsies using modern stem cell technology recapitulate the synaptic loss and dysfunction detected in the patients’ brains, a new study from the University of Eastern Finland shows.

Frontotemporal dementia is a progressive neurodegenerative disease affecting the frontal and temporal lobes of the brain. The most common symptoms are behavioral changes, difficulties in understanding or producing speech, problems in movement, and psychiatric symptoms. Often, frontotemporal dementia has no identified genetic cause, but especially in Finnish patients, hexanucleotide repeat expansion in the C9orf72 gene is a common genetic cause, present in about half of the familial cases and in 20 per cent of the sporadic cases where there is no family history of the disease. However, the disease mechanisms of the different forms of frontotemporal dementia are still poorly understood, and there are currently no effective diagnostic tests or treatments affecting the progression of the disease in clinical use.

Brain imaging and neurophysiological studies have shown that pathological and functional changes underlying the symptoms occur at synapses, the connections between brain neurons, in frontotemporal dementia patients. PET imaging studies have shown significant synapse loss in the brain, and transcranial magnetic stimulation, on the other hand, has indicated disturbed function of both excitatory and inhibitory neurotransmitter systems, leading to deficient neurotransmission. Often, drugs affecting the different neurotransmitter systems are used to mitigate the symptoms of frontotemporal dementia patients.

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