Lifeboat Foundation

Cancer thrives when mutated cells undergo frequent division. Most anti-cancer drugs work by inserting themselves in between the DNA base pairs that encode our genetic information. This process is known as intercalation, and it can result in subtle changes to the DNA molecule’s geometric shape or tertiary structure. These structural changes interfere with the DNA’s transcription and a cell’s replication process, ultimately resulting in cell death.

While intercalating agents used in chemotherapy drugs are highly effective in fighting cancer, they also may kill important cells in the body and lead to other complications such as heart failure. Therefore, researchers are always searching for faster, cheaper and more accurate tools to aid in the design of next-generation anti-cancer drugs with reduced side effects.

A paper published in ACS Nano, one of the top nanotechnology journals in the world, explores this topic. “Modeling and Analysis of Intercalant Effects on Circular DNA Conformation,” (LINK TO http://pubs.acs.org/doi/abs/10.1021/acsnano.6b04876) focuses on the effect of the intercalating agent ethidium bromide (a mimic for many chemotherapy drugs) on the tertiary structure of DNA.

Continue reading “Solid-State Nanopores Unravel Twisted DNA Mystery” »

In a video uploaded to YouTube on August 3rd (below), engineers from the Russian space agency, Roscosmos, proposed an orbiter and lander mission to Ganymede. The video suggests a launch could come in the next decade. Although the commentary is in Russian, the video appears to suggest that Ganymede may be as good a candidate or better for life than Europa.

Singularity University Global Summit is the culmination of the Exponential Conference Series and the definitive place to witness converging exponential technologies and understand how they’ll impact the world.

How many cyborgs did you see during your morning commute today? I would guess at least five. Did they make you nervous? Probably not; you likely didn’t even realize they were there.

In a presentation titled “Biohacking and the Connected Body” at Singularity University Global Summit, Hannes Sjoblad informed the audience that we’re already living in the age of cyborgs. Sjoblad is co-founder of the Sweden-based biohacker network Bionyfiken, a chartered non-profit that unites DIY-biologists, hackers, makers, body modification artists and health and performance devotees to explore human-machine integration.

Continue reading “Biohacking Will Let You Connect Your Body to Anything You Want” »

Feynman told us clearly: “Science is the belief in the ignorance of experts.” Check anything from first principles and experience, ignoring no logical holes, and that is science. Cargo Cult Science arises when the opposing arguments aren’t emphasized. Experts then form and pass down firm beliefs that are delusions. Cargo Cult science is like a perfect replica radio made all of wood: it may have all the trappings of degrees and chairs and journals, but it is missing the key ingredient and won’t function.[1][2]

Vaccine science is cargo cult science according to Feynman’s definition. There are a ton of peer reviewed papers demonstrating that vaccine aluminum is damaging, that vaccines are full of contaminants, that they can disrupt brain and immune system development, that the smallpox vaccine was ineffective, the polio vaccine is of questionable utility, other vaccines’ immunity wanes after only a few years. They never rebut as you can easily verify yourself by examining the citation list here for opposition and then searching the vaccine survey pdfs for the cites. They just ignore it.[3][4][5]

Climate science is cargo cult science. Climate “scientists” have been known to “hide” their own most interesting data, the data contradicting the prevailing theory which is what Feynman said a scientist should emphasize most prominently[6][7]. Alternative theories and methodological objections are ignored or white washed. (Search the IPCC reports for discussion of the opposition.) To say a science is cargo cult science is not to say that there are no papers published in it that are science, but it is to say one should repose zero or negative confidence in any pronouncement one has not personally verified from first principles.

http://TruthSift.com supports Feynman’s model of science applied to everything. Just as in mathematical practice, you can post proofs and refutations. But nothing is considered established unless every proposed refutation has an established counter-refutation. No proposed refutation can be ducked, and anybody who believes they have a rational objection may post it (and see the establishment statuses reflect the objection in real time). Try it out. Check out (and please contribute to) the ongoing diagrammings of the vaccine/climate science etc literatures. When they have passed through true logical review, confronting all the opposing arguments, what remains will be a genuine science.

[1] Richard P Feynman, What is Science? (1968) http://www-oc.chemie.uni-regensburg.de/diaz/img_diaz/feynman…nce_68.pdf
[2] Richard P Feynman, CARGO CULT SCIENCE (adapted from Caltech Commencement Address 1974) https://www.lhup.edu/~DSIMANEK/cargocul.htm
[3] Eric Baum The Top Ten Reasons I Believe Vaccine Safety Is an Epic Mass Delusion (2016) https://lifeboat.com/blog/2016/06/the-top-ten-reasons-i-beli…s-delusion
[4] TruthSift Topic: Are Vaccines Safe? (2016) http://truthsift.com/search_view?statement=Vaccines-are-Safe…p;nid=4083
[5] TruthSift Topic: The Evidence is Weak Vaccines Have Saved More Lives than They Have Cost (2016), http://truthsift.com/search_view?topic=The-Evidence-Is-Weak-…amp;id=520
[6] Climate data hidden both early (data showing very rapid rise before 1500) and in 20th century (showing decline): https://climateaudit.org/2011/03/21/hide-the-decline-the-other-deletion/
[7] More data contradicting theory hidden. https://climateaudit.org/2011/12/01/hide-the-decline-plus/

Watch dramatic footage of the SpaceX rocket exploding at its Cape Canaveral launch pad http://cnnmon.ie/2cgE1QY

A new story out on my Op-Ed yesterday:

Zoltan Istvan, the Transhumanist Party presidential article, argues that Gary Johnson should be let into the debates because America needs another voice.

The first report from the AI100 project says artificial intelligence will deeply affect urban life between now and 2030 – but it won’t take over the world.

Might nature’s bottomless pits actually be ultra-efficient quantum computers? That could explain why data never dies.

Sabine Hossenfelder

The U.S. space agency has contracted with six private companies to develope systems needed for a Mars mission.