Lifeboat Foundation: Safeguarding Humanity
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After more than two years of landing its rockets after launch, SpaceX finally sent one of its used Falcon 9s back into space. The rocket took off from Cape Canaveral, Florida, this evening, sending a communications satellite into orbit, and then landed on one of SpaceX’s drone ships floating in the Atlantic Ocean. It was round two for this particular rocket, which already launched and landed during a mission in April of last year. But the Falcon 9’s relaunch marks the first time an orbital rocket has launched to space for a second time.

SpaceX CEO Elon Musk appeared on the company’s live stream shortly after the landing and spoke about the accomplishment. “It means you can fly and refly an orbital class booster, which is the most expensive part of the rocket. This is going to be, ultimately, a huge revolution in spaceflight,” he said.

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Quantum gravity is a theoretical attempt to reconcile general relativity and the quantum field theories of particle physics. The theory holds that space and time are both quantized in a way that quantum field theory doesn’t account for. Attempts to find evidence in support of the theory have focused on the gravitational effects of black holes. Now, some are using the data collected by the Laser Interferometer Gravitational-Wave Observatory (LIGO) project that has now detected two instances of gravitational waves from the collision of black holes. And there are hints that the data has the evidence the researchers are looking for.

But Afshordi’s idea overthrows what physicists believed they knew about black holes. In Albert Einstein’s theory of general relativity, the event horizon of a black hole – the surface beyond which there is no escape – is insubstantial. Nothing special happens upon crossing it, just that there is no turning around later. If Afshordi is right, however, the inside of the black hole past the event horizon no longer exists. Instead, a Planck-length away from where the horizon would have been, quantum gravitational effects become large, and space-time fluctuations go wild. (The Planck length is a minuscule distance: about 10-35 metres, or 10-20 times the diameter of a proton.) It’s a complete break with relativity.

When he heard of the LIGO results, Afshordi realised that his so-far entirely theoretical idea could be observationally tested. If event horizons are different than expected, the gravitational-wave bursts from merging black holes should be different, too. Events picked up by LIGO should have echoes, a subtle but clear signal that would indicate a departure from standard physics. Such a discovery would be a breakthrough in the long search for a quantum theory of gravity. ‘If they confirm it, I should probably book a ticket to Stockholm,’ Afshordi said, laughing.

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Another biomarker of senescent cells could be p16, a protein whose levels increase when cells stop dividing if old and also a protein whose gene is turned off in many human cancers.

Coming back to our topic – designing senolytics that avoid the apoptosis of young, healthy cells – the ideal senolytic should accomplish two things: –turn on p53 at increased levels to determine stubborn, senescent cells to commit suicide –do that on senescent cells only.

And in order to accomplish the second part, such a drug should be ‘programmed’ to only act on those cells where it recognizes senescence-associated biomarkers. There is no single biomarker today that stains positive or negative on all types of senescence cells, but increased levels of beta-galactosidase and p16 proteins could be a welcome start to identify old cells in vivo when designing such a drug.

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Since the beginning of the Space Age, scientists have relied on multi-stage rockets in order to put spacecraft and payloads into orbit. The same technology has allowed for missions farther into space, sending robotic spacecraft to every planet in the Solar System, and astronauts to the Moon. But looking to the future, it is clear that new ideas will be needed in order to cut costs and expand launch services.

Hence why the ARCA Space Corporation has developed a concept for a single-stage-to-orbit (SSTO) rocket. It’s known as the Haas 2CA, the latest in a series of rockets being developed by the New Mexico-based aerospace company. If all goes as planned, this rocket will be the first SSTO rocket in history, meaning it will be able to place payloads and crew into Earth’s orbit relying on only one stage with one engine.

The rocket was unveiled on Tuesday, March 28th, at their company headquarters in Las Cruces. The rocket is currently seeking FAA approval, and ARCA is working diligently to get it ready for its test launch in 2018 – which will take place at NASA’s Wallops Flight Facility located on Virginia’s eastern shore. If successful, the company hopes to use this rocket to deploy small satellites to orbit in the coming decade.

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Genomic instability (mutations) has been suggested as being one of the primary hallmarks of aging and this research might support that idea. Researchers at John Hopkins report that around 66% of mutations in cancer cells are due to random errors with environment/lifestyle contributing 29% and 5% inherited.

“That finding challenges the common wisdom that cancer is the product of heredity and the environment. “There’s a third cause and this cause of mutations is a major cause,” says cancer geneticist Bert Vogelstein.”

“Such random mutations build up over time and help explain why cancer strikes older people more often. Knowing that the enemy will strike from within even when people protect themselves against external threats indicates that early cancer detection and treatment deserve greater attention than they have previously gotten, Vogelstein says.”

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The team tested their device on a prosthetic hand. When the skin patches on the skin were enabled, the prosthetic could touch and grab soft objects like a normal hand. But when the skin was not turned on, the hand crushed the objects.

The skin requires just 20 nanowatts of power per square centimeter, according to the paper. Right now, the energy captured by the photovoltaic cells has to be used immediately, but the team has another prototype in development that includes flexible supercapacitors to store excess energy.

They are also working on scaling up the material to cover larger areas of a prosthetic or robot, using a method the team pioneered in 2015 for inexpensively producing large sheets of graphene. Dahiya expects the skin will eventually be produced for just $1 for 5 to 10 centimeters of the material.

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Fasting might help T1 diabetics according to new research.

Periodic fasting has long been demonstrated to have beneficial effects on autoimmune disorders, cancer prevention and treatments, cardiovascular disease and a myriad of other ailments. This most recent paper by Cheng et al. may add the treatment of Type 1 diabetes to that list[1]. If successful in humans it has the potential to reverse some or most of the loss of insulin producing cells within the pancreas. Just as remarkable, the treatment itself is relatively straightforward, consisting of a regimented protocol of periodic fasting-like conditions.

Generally speaking, Type 1 diabetes results from an autoimmune mediated depletion of insulin secreting pancreatic beta islet cells. In contrast, Type 2 results from lower cellular sensitivity to insulin. Type 2 is primarily caused by environmental factors such as poor diet.

The current medical approach to treating Type 1 diabetes is the periodic administration of insulin, usually through self-administered injections. Most new therapies focused on curing Type 1 diabetes are looking to repopulating beta islet cells through the use of reprogrammed induced pluripotent stem (iPS) cells.

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