Jan 17, 2017
Protein Associated With Parkinson’s Travels From Brain To Gut
Posted by Karen Hurst in categories: biotech/medical, neuroscience
Pretty wild.
Researchers of the German Center for Neurodegenerative Diseases (DZNE) have found that “alpha-synuclein,” a protein involved in a series of neurological disorders including Parkinson’s disease, is capable of travelling from brain to stomach and that it does so following a specific pathway. Donato Di Monte and co-workers report on this in the journal Acta Neuropathologica. Their study, carried out in rats, sheds new light on pathological processes that could underlie disease progression in humans.
Alpha-synuclein occurs naturally in the nervous system, where it plays an important role in synaptic function. However, in Parkinson’s disease, dementia with Lewy bodies and other neurodegenerative diseases termed “synucleinopathies,” this protein is accumulated within neurons, forming pathological aggregates. Distinct areas of the brain become progressively affected by this condition. The specific mechanisms and pathways involved in this widespread distribution of alpha-synuclein pathology remain to be fully elucidated. Clinical and experimental evidence suggests however that alpha-synuclein — or abnormal forms of it — could “jump” from one neuron to another and thus spread between anatomically interconnected regions.
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